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Protein Page:
MAVS (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MAVS Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. Interacts with DDX58/RIG-I, IFIH1/MDA5, TRAF2 and TRAF6. May interact with IRF3, FADD, RIPK1, CHUK and IKBKB. Does not interact with TBK1. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is cleaved by HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts with PSMA7. Interacts with TRAFD1. Interacts (via C-terminus) with PCBP2 in a complex containing MAVS/IPS1, PCBP2 and ITCH. Interacts with CYLD. Interacts with SRC. Interacts with DHX58/LGP2 and IKBKE. Present in T-cells, monocytes, epithelial cells and hepatocytes. Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Adaptor/scaffold
Cellular Component: peroxisomal membrane; mitochondrial outer membrane; mitochondrion; mitochondrial membrane; integral to membrane
Molecular Function: signal transducer activity; protein binding; CARD domain binding; protein kinase binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; positive regulation of protein import into nucleus, translocation; positive regulation of tumor necrosis factor production; signal transduction; positive regulation of interleukin-8 production; negative regulation of viral genome replication; defense response to bacterium; positive regulation of transcription factor import into nucleus; positive regulation of interferon-beta production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of protein amino acid phosphorylation; positive regulation of defense response to virus by host; defense response to virus; negative regulation of interferon type I production; activation of innate immune response; positive regulation of interferon-alpha production
Reference #:  Q7Z434 (UniProtKB)
Alt. Names/Synonyms: CARD adapter inducing interferon beta; CARD adapter inducing interferon-beta; CARD adaptor inducing IFN-beta; Cardif; DKFZp547C224; DKFZp666M015; FLJ27482; FLJ35386; FLJ38051; FLJ41962; IFN-B promoter stimulator 1; Interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS-1; IPS1; KIAA1271; MAVS; MGC3260; mitochondrial anti-viral signaling protein; mitochondrial antiviral signaling protein; Mitochondrial antiviral-signaling protein; Putative NF-kappa-B-activating protein 031N; virus-induced signaling adapter variant 1b; virus-induced signaling adaptor variant 1a; Virus-induced-signaling adapter; VISA
Gene Symbols: MAVS
Molecular weight: 56,528 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MAVS

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S233‑p, T234‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K7 _MPFAEDKTyKYICR
1 0 Y9-p PFAEDKTyKYICRNF
0 12 S152-p QETQAPEsPGENsEQ
0 1 S157-p PEsPGENsEQALQTL
0 7 S165-p EQALQTLsPRAIPRN
0 1 P173 PRAIPRNPDGGPLES
0 19 S222-p TPSRGPVsPsVSFQP
0 2 S224-p SRGPVsPsVSFQPLA
1 2 S233-p SFQPLARstPRASRL
1 3 T234-p FQPLARstPRASRLP
0 1 R236 PLARstPRASRLPGP
0 2 S253-p SVVSTGTsFSSSsPG
0 3 S258-p GTsFSSSsPGLASAG
0 1 S320 PANPASVSTVPSKLP
0 1 T321 ANPASVSTVPSKLPT
1 1 K362-u RAGMVPSkVPtSMVL
0 2 T365-p MVPSkVPtSMVLTKV
0 1 S373 SMVLTKVSASTVPTD
0 3 T393-p EETPAAPtPAGATGG
0 1 P394 ETPAAPtPAGATGGS
0 1 T398 APtPAGATGGSSAWL
0 1 G400 tPAGATGGSSAWLDS
0 1 S401 PAGATGGSSAWLDSS
0 1 - gap
0 4 S408 SSAWLDSSSENRGLG
0 1 D429-ca GVLASQVdsPFSGCF
0 2 S430-p VLASQVdsPFSGCFE
1 0 K461-u GPEENEYkSEGTFGI
0 1 D490-ca PGPPADPdGGPRPQA
1 0 K500-u PRPQADRkFQEREVP
  mouse

 
K7-u _MTFAEDkTYKYIRD
Y9 TFAEDkTYKYIRDNH
S152-p QDTQPPEsPVENsEQ
S157-p PEsPVENsEQLLQTN
S165 EQLLQTNSGAVARMs
S172-p SGAVARMsGGSLIPS
S220-p IATYGPVsPtVSFQP
T222-p TYGPVsPtVSFQPLP
T231 SFQPLPRTALrTNLL
- gap
R234-m2 PLPRTALrTNLLSGV
S251 SALSADTSLSSSSTG
S256 DTSLSSSSTGSAFAK
K297-u SPRLVPVktMSSKLP
T298-gl PRLVPVktMSSKLPL
R339 YAGTVPSRVPASVAK
A342 TVPSRVPASVAKAPA
P348 PASVAKAPANTIPPE
A369 KETPEGPATKVTTGG
T370 ETPEGPATKVTTGGN
T374 GPATKVTTGGNQtGP
G376 ATKVTTGGNQtGPNS
N377 TKVTTGGNQtGPNSs
T379-p VTTGGNQtGPNSsIR
S384-p NQtGPNSsIRSLHSG
D405 GVLVSQLDEPFSACS
- gap
S437 GPEENEYSSFRIQVD
- gap
Q462 PEPLATQQPQEEEEH
  rat

 
K7 _MTFAEEKTYKYIRY
Y9 TFAEEKTYKYIRYNH
S152 QDTQPPKSPVENSEE
S157 PKSPVENSEEPPQAN
- gap
S172 FGAIPRMSGDSLISS
S220 IATYGPVSPTVSFQP
T222 TYGPVSPTVSFQPLP
- gap
- gap
R234 PLPRIAPRTNLSPGV
T251 SALSAKTTLSSSSTG
S256 KTTLSSSSTGSAFAK
N300 SIKPVPVNTMSSKLP
T301 IKPVPVNTMSSKLPI
K342 YTGIVPSKVTASVAK
A345 IVPSKVTASVAKAsA
S351-p TASVAKAsASTMPPE
A372 KETLEAPAtVVTtGs
T373-p ETLEAPAtVVTtGss
T377-p APAtVVTtGssLtRP
S379-p AtVVTtGssLtRPDI
S380-p tVVTtGssLtRPDIS
T382-p VTtGssLtRPDISSR
S387 sLtRPDISSRSLHSG
D408 GVLVSQVDNEPFSAC
- gap
S441 GPEENEYSSFRIQVD
- gap
Q466 PEPLATQQSPEEEEP
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