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Protein Page:
MAVS (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MAVS Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. Interacts with DDX58/RIG-I, IFIH1/MDA5, TRAF2 and TRAF6. May interact with IRF3, FADD, RIPK1, CHUK and IKBKB. Does not interact with TBK1. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is cleaved by HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts with PSMA7. Interacts with TRAFD1. Interacts (via C-terminus) with PCBP2 in a complex containing MAVS/IPS1, PCBP2 and ITCH. Interacts with CYLD. Interacts with SRC. Interacts with DHX58/LGP2 and IKBKE. Present in T-cells, monocytes, epithelial cells and hepatocytes. Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Cellular Component: peroxisomal membrane; mitochondrial outer membrane; mitochondrion; mitochondrial membrane; integral to membrane
Molecular Function: protein binding; signal transducer activity; CARD domain binding; protein kinase binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; positive regulation of protein import into nucleus, translocation; positive regulation of tumor necrosis factor production; signal transduction; positive regulation of interleukin-8 production; negative regulation of viral genome replication; defense response to bacterium; positive regulation of transcription factor import into nucleus; positive regulation of interferon-beta production; innate immune response; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; positive regulation of defense response to virus by host; negative regulation of interferon type I production; defense response to virus; activation of innate immune response; positive regulation of interferon-alpha production
Reference #:  Q7Z434 (UniProtKB)
Alt. Names/Synonyms: CARD adapter inducing interferon beta; CARD adapter inducing interferon-beta; CARD adaptor inducing IFN-beta; Cardif; DKFZp547C224; DKFZp666M015; FLJ27482; FLJ35386; FLJ38051; FLJ41962; IFN-B promoter stimulator 1; Interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS-1; IPS1; KIAA1271; MAVS; MGC3260; mitochondrial anti-viral signaling protein; mitochondrial antiviral signaling protein; Mitochondrial antiviral-signaling protein; Putative NF-kappa-B-activating protein 031N; virus-induced signaling adapter variant 1b; virus-induced signaling adaptor variant 1a; Virus-induced-signaling adapter; VISA
Gene Symbols: MAVS
Molecular weight: 56,528 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MAVS

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S233‑p, T234‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K7 _MPFAEDKTyKYICR
0 1 K7 _MPFAEDKTyKYICR
1 0 Y9-p PFAEDKTyKYICRNF
0 1 T45-p DQDRLRAtCTLSGNR
0 1 Y92-p ADEVASVyQSYQPRT
0 1 K136 PYNSCREKEPSYPMP
0 1 S139 SCREKEPSYPMPVQE
0 1 T147 YPMPVQETQAPEsPG
0 17 S152-p QETQAPEsPGENsEQ
0 4 S157-p PEsPGENsEQALQTL
0 11 S165-p EQALQTLsPRAIPRN
0 1 P173 PRAIPRNPDGGPLEs
0 1 P177 PRNPDGGPLEsSSDL
0 1 S180-p PDGGPLEsSSDLAAL
0 1 S181 DGGPLEsSSDLAALs
0 2 S188-p SSDLAALsPLTSSGH
0 1 T215-p AGATSSLtPSRGPVs
0 25 S222-p tPSRGPVsPsVSFQP
0 2 S224-p SRGPVsPsVSFQPLA
1 4 S233-p SFQPLARstPRASRL
1 5 T234-p FQPLARstPRASRLP
0 1 R236 PLARstPRASRLPGP
0 1 T250-p PTGSVVStGTsFSss
0 3 S253-p SVVStGTsFSsssPG
0 1 S256-p StGTsFSsssPGLAS
0 1 S257-p tGTsFSsssPGLASA
0 5 S258-p GTsFSsssPGLASAG
0 1 S275-p EGKQGAEsDQAEPII
0 1 T300-p SLPSKVPttLMPVNt
0 1 T301-p LPSKVPttLMPVNtV
0 1 T307-p ttLMPVNtVALKVPA
0 1 S320 PANPASVSTVPSKLP
0 1 T321 ANPASVSTVPSKLPT
0 1 S361-p TRAGMVPskVPtsMV
1 1 K362-ub RAGMVPskVPtsMVL
0 2 T365-p MVPskVPtsMVLTKV
0 1 S366-p VPskVPtsMVLTKVs
0 2 S373-p sMVLTKVsASTVPTD
0 1 S383-p TVPTDGSsRNEETPA
0 5 T393-p EETPAAPtPAGATGG
0 1 P394 ETPAAPtPAGATGGS
0 1 T398 APtPAGATGGSSAWL
0 1 S401 PAGATGGSSAWLDsS
0 1 S402 AGATGGSSAWLDsSS
0 1 A403 GATGGSSAWLDsSSE
0 1 S407-p GSSAWLDsSSENRGL
0 4 S408 SSAWLDsSSENRGLG
0 1 S416-p SENRGLGsELsKPGV
0 1 S419-p RGLGsELsKPGVLAS
0 1 D429-ca GVLASQVdsPFSGCF
0 4 S430-p VLASQVdsPFSGCFE
1 0 K461-ub GPEENEYkSEGTFGI
0 1 S475-p IHVAENPsIQLLEGN
0 1 D490-ca PGPPADPdGGPRPQA
1 0 K500-ub PRPQADRkFQEREVP
  mouse

 
K7-ub _MTFAEDkTYKYIRD
K7-sc _MTFAEDkTYKYIRD
Y9 TFAEDkTYKYIRDNH
S45 DQDRLRASYRQIGNR
Y92 ADQVTRVYQSYLPPG
T137-p PDHGLREtPsCPKPV
S139-p HGLREtPsCPKPVQD
T147-p CPKPVQDtQPPEsPV
S152-p QDtQPPEsPVENsEQ
S157-p PEsPVENsEQLLQTN
S165 EQLLQTNSGAVARMs
S172-p SGAVARMsGGsLIPs
S175-p VARMsGGsLIPsPNQ
P178 MsGGsLIPsPNQQAL
S179-p sGGsLIPsPNQQALs
S186-p sPNQQALsPQPSREH
I213 ANVASVPIATYGPVs
S220-p IATYGPVsPtVSFQP
T222-p TYGPVsPtVSFQPLP
T231 SFQPLPRTALrTNLL
A232 FQPLPRTALrTNLLS
R234-m2 PLPRTALrTNLLSGV
A248 VTVSALSADTSLSSS
S251 SALSADTSLSSSSTG
S254 SADTSLSSSSTGSAF
S255 ADTSLSSSSTGSAFA
S256 DTSLSSSSTGSAFAK
- gap
T284 TTLTNSVTTSSVPSP
T285 TLTNSVTTSSVPSPR
- gap
K297-ub SPRLVPVktMSSKLP
T298-gl PRLVPVktMSSKLPL
S338 VYAGTVPSRVPASVA
R339 YAGTVPSRVPASVAK
A342 TVPSRVPASVAKAPA
S343 VPSRVPASVAKAPAN
P348 PASVAKAPANTIPPE
S358 TIPPERNSKQAKETP
A369 KETPEGPATKVTTGG
T370 ETPEGPATKVTTGGN
T374 GPATKVTTGGNQtGP
N377 TKVTTGGNQtGPNss
Q378 KVTTGGNQtGPNssI
T379-p VTTGGNQtGPNssIR
S383-p GNQtGPNssIRSLHS
S384-p NQtGPNssIRSLHSG
P392 IRSLHSGPEMSKPGV
S395 LHSGPEMSKPGVLVS
D405 GVLVSQLDEPFSACS
E406 VLVSQLDEPFSACSV
S437 GPEENEYSSFRIQVD
S448 IQVDESPSADLLGSP
- gap
Q462 PEPLATQQPQEEEEH
  rat

 
K7 _MTFAEEKTYKYIRY
K7 _MTFAEEKTYKYIRY
Y9 TFAEEKTYKYIRYNH
S45 DQDRLRASYKQLGNQ
Y92 AEQVTRVYQSYLPPG
K137 PDSGFQDKPGYPKPV
Y140 GFQDKPGYPKPVQDT
T147 YPKPVQDTQPPKsPV
S152-p QDTQPPKsPVENSEE
S157 PKsPVENSEEPPQAN
F165 EEPPQANFGAIPRMS
S172 FGAIPRMSGDSLISS
S175 IPRMSGDSLISSPNP
S178 MSGDSLISSPNPPAL
S179 SGDSLISSPNPPALS
S186 SPNPPALSPQPSREH
I213 ANVDSVPIATYGPVS
S220 IATYGPVSPTVSFQP
T222 TYGPVSPTVSFQPLP
I231 SFQPLPRIAPRTNLS
A232 FQPLPRIAPRTNLSP
R234 PLPRIAPRTNLSPGV
A248 VTVSALSAKTTLSSS
T251 SALSAKTTLSSSSTG
S254 SAKTTLSSSSTGSAF
S255 AKTTLSSSSTGSAFA
S256 KTTLSSSSTGSAFAK
- gap
T287 GVPTNSVTTSSVPSI
T288 VPTNSVTTSSVPSIK
- gap
N300 SIKPVPVNTMSSKLP
T301 IKPVPVNTMSSKLPI
S341 VYTGIVPSKVTASVA
K342 YTGIVPSKVTASVAK
A345 IVPSKVTASVAKAsA
S346 VPSKVTASVAKAsAS
S351-p TASVAKAsASTMPPE
N361 TMPPERNNKQAKETL
A372 KETLEAPAtVVTtGs
T373-p ETLEAPAtVVTtGss
T377-p APAtVVTtGssLtRP
S379-p AtVVTtGssLtRPDI
S380-p tVVTtGssLtRPDIS
T382-p VTtGssLtRPDISSR
I386 ssLtRPDISSRSLHS
S387 sLtRPDISSRSLHSG
P395 SRSLHSGPELSKPGV
S398 LHSGPELSKPGVLVS
D408 GVLVSQVDNEPFSAC
E410 LVSQVDNEPFSACSM
S441 GPEENEYSSFRIQVD
S452 IQVDKSPSVDLLGSP
- gap
Q466 PEPLATQQSPEEEEP
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