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Protein Page:
MEIS1 (human)

Overview
MEIS1 Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7). Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Chromosomal Location of Human Ortholog: 2p14
Cellular Component: nucleus
Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: negative regulation of myeloid cell differentiation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development
Reference #:  O00470 (UniProtKB)
Alt. Names/Synonyms: Homeobox protein Meis1; Meis homeobox 1; MEIS1; myeloid ecotropic viral integration site 1
Gene Symbols: MEIS1
Molecular weight: 43,016 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MEIS1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S21 MDGVGIPSTMYGDPH
0 1 T22 DGVGIPSTMYGDPHA
0 1 Y24 VGIPSTMYGDPHAAR
0 3 S196-p DREGGSKsDSEDITR
  mouse

 
S21-p MDGVGIPstMyGDPH
T22-p DGVGIPstMyGDPHA
Y24-p VGIPstMyGDPHAAR
S196 DREGGSKSDSEDVTR
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