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Protein Page:
NALP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NALP1 Able to form cytoplasmic structures termed death effector filaments. Enhances APAF1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. Stimulates apoptosis through activation of caspase-3. Involved in activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Binds ATP. Interacts strongly with caspase-2, weakly with caspase-9 and with APAF1 in a cytochrome c-inducible way, leading to the formation of an apoptosome. This interaction may be ATP-dependent. Part of the NALP1 inflammasome complex which is involved in activation of caspase-1 and caspase-5, leading to processing of IL1B and IL18. The complex is activated by bacterial muramyl dipeptide which triggers ATP-binding and oligomerization of NALP1. Widely expressed. Isoform 1 and isoform 2 are expressed in peripheral blood leukocytes and chronic myelogenous leukemia cell line K-562, followed by thymus, spleen and heart. Also detected in brain, lung, placenta, small intestine, colon, kidney, liver, muscle, testis and epithelial cells. Absent from hematopoietic progenitor cells but expressed upon differentiation of cells into granulocytes and, to a lesser extent, monocytes. In peripheral blood cells, highest levels are found in T-lymphocytes, granulocytes and monocytes. Expression is significantly increased in bone marrow blast cells of some acute leukemia patients but not in solid tumors. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Cellular Component: intracellular; cytosol; nucleus
Molecular Function: protein domain specific binding; protein binding; enzyme binding; caspase activator activity; ATP binding
Biological Process: caspase activation; neuron apoptosis; apoptosis; response to muramyl dipeptide; regulation of inflammatory response; defense response to bacterium; innate immune response; positive regulation of interleukin-1 beta secretion
Reference #:  Q9C000 (UniProtKB)
Alt. Names/Synonyms: CARD7; caspase recruitment domain protein 7; Caspase recruitment domain-containing protein 7; CLR17.1; Death effector filament-forming ced-4-like apoptosis protein; DEFCAP; DEFCAP-L/S; DKFZp586O1822; KIAA0926; NAC; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; NALP1; NLR family, pyrin domain containing 1; NLRP1; Nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; PP1044; SLEV1; VAMAS1
Gene Symbols: NLRP1
Molecular weight: 165,866 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NALP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S823-p SGNSLSHsAVKSLCK
0 1 E977 ELRALEQEKPQLLIF
0 1 T995 KPSVMTPTEGLDtGE
0 1 T1000-p TPTEGLDtGEMSNST
0 1 K1428-ac TRPSQMRkLFSLSQS
0 1 K1439-ac LSQSWDRkCKDGLYQ
  NALP1 iso4  
S823 SGNSLSHSAVKSLCK
- gap
T965-p KPSVMTPtEGLDTGE
T970 TPtEGLDTGEMSNST
K1398 TRPSQMRKLFSLSQS
K1409 LSQSWDRKCKDGLYQ
  mouse

 
Y648 SGNPLSYYAVHSLCT
K798-ac ELRTLEAkNPKLLIS
T816 KPHVMVPTMNMDKEE
K821 VPTMNMDKEEVGDSQ
K1258 TNQDKMRKLFSLSRS
D1269 LSRSWSWDCKDQFYQ
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