a major structural protein of the eye lens. A member of the small heat shock protein (sHSP also known as the HSP20) family. Alpha-B is expressed in the lens as well as other tissues. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Note: This description may include information from UniProtKB.
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; metal ion binding; microtubule binding; cytoskeletal protein binding; unfolded protein binding; structural constituent of eye lens
Biological Process: lens development in camera-type eye; muscle development; camera-type eye development; protein folding; microtubule polymerization or depolymerization; stress-activated MAPK cascade; glucose metabolic process; negative regulation of caspase activity; tubulin folding; response to hydrogen peroxide; negative regulation of intracellular transport; response to hypoxia; negative regulation of cell growth; protein homooligomerization; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.