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Protein Page:
CRYAB (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CRYAB a major structural protein of the eye lens. A member of the small heat shock protein (sHSP also known as the HSP20) family. Alpha-B is expressed in the lens as well as other tissues. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Note: This description may include information from UniProtKB.
Protein type: Chaperone
Cellular Component: microtubule cytoskeleton; Golgi apparatus; I band; cell surface; contractile fiber; mitochondrion; cytoplasm; actin filament bundle; plasma membrane; nucleus; cytosol; Z disc
Molecular Function: protein binding; protein homodimerization activity; microtubule binding; metal ion binding; cytoskeletal protein binding; unfolded protein binding; structural constituent of eye lens
Biological Process: lens development in camera-type eye; muscle development; camera-type eye development; protein folding; microtubule polymerization or depolymerization; stress-activated MAPK cascade; glucose metabolic process; negative regulation of caspase activity; tubulin folding; response to hydrogen peroxide; negative regulation of intracellular transport; response to hypoxia; negative regulation of cell growth; protein homooligomerization; negative regulation of apoptosis
Reference #:  P23927 (UniProtKB)
Alt. Names/Synonyms: alpha B-crystallin; Alpha(B)-crystallin; Alpha-crystallin B chain; Crya-2; Crya2; Cryab; crystallin, alpha 2; crystallin, alpha B; HspB5; P23
Gene Symbols: Cryab
Molecular weight: 20,069 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CRYAB
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
apoptosis, inhibited: S59‑p
cytoskeletal reorganization: S59‑p
intracellular localization: S59‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        mouse

 
15 9 S19-p RPFFPFHsPsRLFDQ
0 5 S21-p FFPFHsPsRLFDQFF
0 1 R22 FPFHsPsRLFDQFFG
1 0 S35 FGEHLLESDLFSTAT
1 2 S43 DLFSTATSLsPFYLR
24 6 S45-p FSTATSLsPFYLRPP
0 1 R50 SLsPFYLRPPSFLRA
0 2 S53 PFYLRPPSFLRAPsW
30 12 S59-p PSFLRAPsWIDtGLS
0 1 T63-p RAPsWIDtGLSEMRL
0 1 K72-u LSEMRLEkDRFSVNL
0 1 R74 EMRLEkDRFSVNLDV
0 2 S76 RLEkDRFSVNLDVkH
0 2 K82-u FSVNLDVkHFSPEEL
0 1 K90 HFSPEELKVkVLGDV
0 8 K90-u HFSPEELkVkVLGDV
2 2 K92 SPEELkVKVLGDVIE
0 10 K92-u SPEELkVkVLGDVIE
0 1 K103-u DVIEVHGkHEERQDE
0 1 T132 PADVDPLTITSSLSS
0 1 S135 VDPLTITSSLSSDGV
0 1 T144 LSSDGVLTVNGPRkQ
0 1 K150-u LTVNGPRkQVSGPER
0 1 S153 NGPRkQVSGPERtIP
0 1 T158-p QVSGPERtIPITREE
1 0 K166 IPITREEKPAVAAAP
0 8 K166-u IPITREEkPAVAAAP
3 1 A170 REEkPAVAAAPkk__
0 5 K174-u PAVAAAPkk______
0 3 K175-u AVAAAPkk_______
  human

 
S19-p RPFFPFHsPsrLFDQ
S21-p FFPFHsPsrLFDQFF
R22-m FPFHsPsrLFDQFFG
S35 FGEHLLESDLFPTST
S43-p DLFPTSTsLsPFYLr
S45-p FPTSTsLsPFYLrPP
R50-m sLsPFYLrPPsFLRA
S53-p PFYLrPPsFLRAPsW
S59-p PsFLRAPsWFDTGLS
T63 RAPsWFDTGLSEMRL
K72 LSEMRLEKDrFsVNL
R74-m1 EMRLEKDrFsVNLDV
S76-p RLEKDrFsVNLDVKH
K82 FsVNLDVKHFSPEEL
K90 HFSPEELKVkVLGDV
K90 HFSPEELKVkVLGDV
K92-a SPEELKVkVLGDVIE
K92 SPEELKVKVLGDVIE
K103 DVIEVHGKHEERQDE
T132-p PADVDPLtITsSLSS
S135-p VDPLtITsSLSSDGV
T144-p LSSDGVLtVNGPRKQ
K150 LtVNGPRKQVSGPER
S153 NGPRKQVSGPERTIP
T158 QVSGPERTIPITREE
K166-a IPITREEkPAVTAAP
K166-u IPITREEkPAVTAAP
T170 REEkPAVTAAPKK__
K174 PAVTAAPKK______
K175 AVTAAPKK_______
  rat

 
S19-p RPFFPFHsPSRLFDQ
S21 FFPFHsPSRLFDQFF
R22 FPFHsPSRLFDQFFG
S35 FGEHLLESDLFSTAT
S43 DLFSTATSLsPFYLR
S45-p FSTATSLsPFYLRPP
R50 SLsPFYLRPPSFLRA
S53 PFYLRPPSFLRAPsW
S59-p PSFLRAPsWIDTGLS
T63 RAPsWIDTGLSEMRM
K72 LSEMRMEKDRFSVNL
R74 EMRMEKDRFSVNLDV
S76 RMEKDRFSVNLDVKH
K82 FSVNLDVKHFSPEEL
K90 HFSPEELKVKVLGDV
K90 HFSPEELKVKVLGDV
K92 SPEELKVKVLGDVIE
K92 SPEELKVKVLGDVIE
K103 DVIEVHGKHEERQDE
T132 PADVDPLTITSSLSS
S135 VDPLTITSSLSSDGV
T144 LSSDGVLTVNGPRKQ
K150 LTVNGPRKQASGPER
S153 NGPRKQASGPERTIP
T158 QASGPERTIPITREE
K166 IPITREEKPAVtAAP
K166 IPITREEKPAVtAAP
T170-gl REEKPAVtAAPKK__
K174 PAVtAAPKK______
K175 AVtAAPKK_______
  rabbit

 
S19-p RPFFPFHsPsRLFDQ
S21-p FFPFHsPsRLFDQFF
R22 FPFHsPsRLFDQFFG
S35 FGEHLLESDLFPTST
S43 DLFPTSTSLsPFYLR
S45-p FPTSTSLsPFYLRPP
R50 SLsPFYLRPPSFLRA
S53 PFYLRPPSFLRAPsW
S59-p PSFLRAPsWIDTGLS
T63 RAPsWIDTGLSEMRL
K72 LSEMRLEKDRFSVNL
R74 EMRLEKDRFSVNLDV
S76 RLEKDRFSVNLDVKH
K82 FSVNLDVKHFSPEEL
K90 HFSPEELKVKVLGDV
K90 HFSPEELKVKVLGDV
K92 SPEELKVKVLGDVIE
K92 SPEELKVKVLGDVIE
K103 DVIEVHGKHEERQDE
T132 PADVDPLTITSSLSS
S135 VDPLTITSSLSSDGV
T144 LSSDGVLTVNGPRKQ
K150 LTVNGPRKQAPGPER
P153 NGPRKQAPGPERTIP
T158 QAPGPERTIPITREE
K166 IPITREEKPAVTAAP
K166 IPITREEKPAVTAAP
T170 REEKPAVTAAPKK__
K174 PAVTAAPKK______
K175 AVTAAPKK_______
  pig

 
S19 RPFFPFHSPSRLFDQ
S21 FFPFHSPSRLFDQFF
R22 FPFHSPSRLFDQFFG
S35 FGEHLLESDLFPAST
S43 DLFPASTSLSPFYFR
S45 FPASTSLSPFYFRPP
R50 SLSPFYFRPPSFLRA
S53 PFYFRPPSFLRAPsW
S59-p PSFLRAPsWIDTGLS
T63 RAPsWIDTGLSEMRL
K72 LSEMRLEKDRFSVNL
R74 EMRLEKDRFSVNLDV
S76 RLEKDRFSVNLDVKH
K82 FSVNLDVKHFSPEEL
K90 HFSPEELKVKVLGDV
K90 HFSPEELKVKVLGDV
K92 SPEELKVKVLGDVIE
K92 SPEELKVKVLGDVIE
K103 DVIEVHGKHEERQDE
T132 PADVDPLTITSSLSS
S135 VDPLTITSSLSSDGV
T144 LSSDGVLTVNGPRRQ
R150 LTVNGPRRQASGPER
S153 NGPRRQASGPERTIP
T158 QASGPERTIPITREE
K166 IPITREEKPAVTAAP
K166 IPITREEKPAVTAAP
T170 REEKPAVTAAPKK__
K174 PAVTAAPKK______
K175 AVTAAPKK_______
  cow

 
S19-p RPFFPFHsPsRLFDQ
S21-p FFPFHsPsRLFDQFF
R22 FPFHsPsRLFDQFFG
S35-p FGEHLLEsDLFPAST
S43-p DLFPASTsLsPFYLR
S45-p FPASTsLsPFYLRPP
R50 sLsPFYLRPPsFLRA
S53-p PFYLRPPsFLRAPsW
S59-p PsFLRAPsWIDTGLS
T63 RAPsWIDTGLSEMRL
K72 LSEMRLEKDRFsVNL
R74 EMRLEKDRFsVNLDV
S76-p RLEKDRFsVNLDVKH
K82 FsVNLDVKHFSPEEL
K90-a HFSPEELkVkVLGDV
K90 HFSPEELKVkVLGDV
K92-a SPEELkVkVLGDVIE
K92 SPEELkVKVLGDVIE
K103 DVIEVHGKHEERQDE
A132 PADVDPLAITSSLSS
S135 VDPLAITSSLSSDGV
T144 LSSDGVLTVNGPRKQ
K150 LTVNGPRKQAsGPER
S153-p NGPRKQAsGPERTIP
T158 QAsGPERTIPITREE
K166 IPITREEKPAVtAAP
K166 IPITREEKPAVtAAP
T170-gl REEKPAVtAAPKK__
K174 PAVtAAPKK______
K175 AVtAAPKK_______
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