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Protein Page:
STIM2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
STIM2 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. Oligomer with STIM1. Interacts with ORAI1. Expressed in all tissues and tumor cell lines examined. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; plasma membrane
Molecular Function: protein binding; store-operated calcium channel activity; calcium channel regulator activity; calcium ion binding
Biological Process: cellular calcium ion homeostasis; activation of store-operated calcium channel activity; positive regulation of calcium ion transport
Reference #:  Q9P246 (UniProtKB)
Alt. Names/Synonyms: FLJ39527; KIAA1482; STIM2; Stromal interaction molecule 2
Gene Symbols: STIM2
Molecular weight: 83,971 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STIM2
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 3 T28 HLRGRRATGSAATAA
0 1 K283-u NRNVAVEkQNLERKM
0 1 K298 MDEINYAKEEACRLR
0 7 Y320-p CELSRRQyAEQELEQ
0 2 S460 SLTSSLYSDHSWVVM
0 3 S518-p SLCRSRRsIVPssPQ
0 2 S522-p SRRsIVPssPQPQRA
0 21 S523-p RRsIVPssPQPQRAQ
0 3 P526 IVPssPQPQRAQLAP
0 2 S539-p APHAPHPsHPRHPHH
0 2 S566-p PDILSVSsCPALYRN
0 4 S609-p SSIGRKQsPPLSLEI
0 2 L612 GRKQsPPLSLEIyQT
0 1 S613 RKQsPPLSLEIyQTL
0 2 Y617-p PPLSLEIyQTLsPRK
0 1 S621-p LEIyQTLsPRKIsRD
0 2 S626-p TLsPRKIsRDEVSLE
0 4 S631 KIsRDEVSLEDSSRG
0 4 S640-p EDSSRGDsPVTVDVS
0 1 T643 SRGDsPVTVDVSWGS
0 4 S650 TVDVSWGSPDCVGLT
0 4 S661-p VGLTETKsMIFSPAS
0 3 S678-p YNGILEKsCsMNQLS
0 10 S680-p GILEKsCsMNQLSSG
0 1 S685 sCsMNQLSSGIPVPK
0 1 S697-p VPKPRHTsCsSAGND
0 1 S699-p KPRHTsCsSAGNDSK
0 6 S719-p PSVARISsIPHDLCH
  mouse

 
S28-p HLRGRRAsGSAGAAA
K283 NRTVAVEKQNLERKM
K298-u MDEINYAkEEACRLR
Y320-p CELSRRQyAEQELEQ
S460-p SLTSSLYsDHSWVVM
S518-p SLCRSRRsIVPssPQ
S522-p SRRsIVPssPQsQRA
S523-p RRsIVPssPQsQRAQ
S526-p IVPssPQsQRAQLPA
A539 PAHAPLAAHPRHPHH
S566-p PDILSVSsCPALYRN
S609-p SSSGRKPsPPssLEM
S612-p GRKPsPPssLEMyQT
S613-p RKPsPPssLEMyQTL
Y617-p PPssLEMyQTLSSRK
S621 LEMyQTLSSRKIsRD
S626-p TLSSRKIsRDELsLE
S631-p KIsRDELsLEDSSRG
S640-p EDSSRGEsPVtADVS
T643-p SRGEsPVtADVSRGs
S650-p tADVSRGsPECVGLT
S661-p VGLTETKsMIFSPAS
S678 YNGILEKSCsMHQLs
S680-p GILEKSCsMHQLsSG
S685-p SCsMHQLsSGIPVPH
S697 VPHPRHTSCSSAGND
S699 HPRHTSCSSAGNDSK
S719-p SNVSRVSsIPHDLCH
  rat

 
S94 HLRGRRASGSAGAAA
K349 NRTVAVEKQNLERKM
K364 MDEINYAKEEACRLR
Y386 CELSRRQYAEQELEQ
S526 SLTSSLYSDHSWVVM
S584 SLCRSRRSIVPSsPQ
S588 SRRSIVPSsPQsQRA
S589-p RRSIVPSsPQsQRAQ
S592-p IVPSsPQsQRAQLPA
A605 PAHAPLAAHPRHPHH
S629 PDILSVSSCPALYRN
S672 SSIGRKQSPPSSLEI
S675 GRKQSPPSSLEIYQT
S676 RKQSPPSSLEIYQTL
Y680 PPSSLEIYQTLSSRK
S684 LEIYQTLSSRKISRD
S689 TLSSRKISRDELSLE
S694 KISRDELSLEDSSRG
S703 EDSSRGDSPVTADVS
T706 SRGDSPVTADVSRGS
S713 TADVSRGSPECVGLT
S724 VGLTETKSMIFSPAS
S741 YNGILEKSCSMHQLS
S743 GILEKSCSMHQLSSG
S748 SCSMHQLSSGIPVPN
S760 VPNPRHTSCSLAGSD
S762 NPRHTSCSLAGSDSK
S782 SSVSRVGSIPHDLCH
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