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Protein Page:
ETFB (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ETFB The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Defects in ETFB are the cause of glutaric aciduria type 2B (GA2B). GA2B is an autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Belongs to the ETF beta-subunit/FixA family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Mitochondrial
Cellular Component: mitochondrion; intracellular membrane-bound organelle; mitochondrial matrix
Molecular Function: electron carrier activity
Reference #:  P38117 (UniProtKB)
Alt. Names/Synonyms: Beta-ETF; electron transfer flavoprotein beta subunit; electron transfer flavoprotein beta-subunit; Electron transfer flavoprotein subunit beta; electron transfer flavoprotein, beta polypeptide; electron-transfer-flavoprotein, beta polypeptide; electron-transferring-flavoprotein, beta polypeptide; ETFB; FP585; MADD
Gene Symbols: ETFB
Molecular weight: 27,844 Da
Basal Isoelectric point: 8.25  Predict pI for various phosphorylation states
Select Structure to View Below

ETFB
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 2 K11-a LRVLVAVkRVIDYAV
0 1 - gap
0 1 - gap
0 2 K23-a YAVKIRVkPDRTGVV
0 1 R26 KIRVkPDRTGVVTDG
0 1 K35-a GVVTDGVkHSMNPFC
0 4 K56-a AVRLKEKkLVkEVIA
0 8 K59-a LKEKkLVkEVIAVSC
0 1 T77 QCQETIRTALAMGAD
0 1 R98 VPPAEAERLGPLQVA
0 3 K110-a QVARVLAkLAEkEkV
0 2 K114-a VLAkLAEkEkVDLVL
0 15 K116-a AkLAEkEkVDLVLLG
0 1 K116 AkLAEkEKVDLVLLG
0 1 T172-p EIDGGLEtLRLKLPA
0 3 K176 GLEtLRLKLPAVVtA
0 1 K176 GLEtLRLKLPAVVtA
0 2 T182-p LKLPAVVtADLRLNE
0 12 Y192-p LRLNEPRyAtLPNIM
0 22 T194-p LNEPRyAtLPNIMkA
0 5 K200-m1 AtLPNIMkAkKKKIE
0 1 K200-a AtLPNIMkAkKKKIE
0 5 K200-m2 AtLPNIMkAkKKKIE
0 1 K200-m3 AtLPNIMkAkKKKIE
0 2 K202-m1 LPNIMkAkKKKIEVI
0 3 K202-m2 LPNIMkAkKKKIEVI
0 4 K210-a KKKIEVIkPGDLGVD
0 1 K210 KKKIEVIKPGDLGVD
0 1 K221-a LGVDLTSkLSVIsVE
0 1 S226-p TSkLSVIsVEDPPQR
0 1 T234 VEDPPQRTAGVKVET
0 1 K238 PQRTAGVKVETTEDL
0 1 T242 AGVKVETTEDLVAKL
0 1 K248 TTEDLVAKLKEIGRI
0 1 K248 TTEDLVAKLKEIGRI
  ETFB iso2  
- gap
Y2-p ______MyLSLWVtI
T8-p MyLSLWVtINTVNLR
K114 PAGQIRVKPDRTGVV
R117 QIRVKPDRTGVVTDG
K126 GVVTDGVKHSMNPFC
K147 AVRLKEKKLVKEVIA
K150 LKEKKLVKEVIAVSC
T168 QCQETIRTALAMGAD
R189 VPPAEAERLGPLQVA
K201 QVARVLAKLAEKEKV
K205 VLAKLAEKEKVDLVL
K207 AKLAEKEKVDLVLLG
K207 AKLAEKEKVDLVLLG
T263 EIDGGLETLRLKLPA
K267 GLETLRLKLPAVVTA
K267 GLETLRLKLPAVVTA
T273 LKLPAVVTADLRLNE
Y283 LRLNEPRYATLPNIM
T285 LNEPRYATLPNIMKA
K291 ATLPNIMKAKKKKIE
K291 ATLPNIMKAKKKKIE
K291 ATLPNIMKAKKKKIE
K291 ATLPNIMKAKKKKIE
K293 LPNIMKAKKKKIEVI
K293 LPNIMKAKKKKIEVI
K301 KKKIEVIKPGDLGVD
K301 KKKIEVIKPGDLGVD
K312 LGVDLTSKLSVISVE
S317 TSKLSVISVEDPPQR
T325 VEDPPQRTAGVKVET
K329 PQRTAGVKVETTEDL
T333 AGVKVETTEDLVAKL
K339 TTEDLVAKLKEIGRI
K339 TTEDLVAKLKEIGRI
  mouse

 
K11 LRALVAVKRVIDFAV
- gap
- gap
K23-a FAVKIRVkPDkSGVV
K26-a KIRVkPDkSGVVTDG
K35-a GVVTDGVkHSMNPFC
K56-a AVRLKEKkLVkEIIA
K59-a LKEKkLVkEIIAVSC
T77-p QCQETIRtALAMGAD
S98-p IPGAQAEsLGPLQVA
K110-a QVARVLAkLAEkEkV
K114-a VLAkLAEkEkVDLLF
K116-a AkLAEkEkVDLLFLG
K116-u AkLAEkEkVDLLFLG
T172 EIDGGLETLRLkLPA
K176-a GLETLRLkLPAVVTA
K176-u GLETLRLkLPAVVTA
T182 LkLPAVVTADLRLNE
Y192 LRLNEPRYATLPNIM
T194 LNEPRYATLPNIMKA
K200 ATLPNIMKAKKKKIE
K200 ATLPNIMKAKKKKIE
K200 ATLPNIMKAKKKKIE
K200 ATLPNIMKAKKKKIE
K202 LPNIMKAKKKKIEVV
K202 LPNIMKAKKKKIEVV
K210-a KKKIEVVkAGDLGVD
K210-u KKKIEVVkAGDLGVD
K221 LGVDLTSKVSVISVE
S226 TSKVSVISVEEPPQR
S234-p VEEPPQRsAGVkVET
K238-u PQRsAGVkVETtEDL
T242-p AGVkVETtEDLVAkL
K248-a TtEDLVAkLKEVGRI
K248-u TtEDLVAkLKEVGRI
  rat

 
K11 LRALVAVKRVIDFAV
- gap
- gap
K23 FAVKIRVKPDKSGVV
K26 KIRVKPDKSGVVTDG
K35 GVVTDGVKHSMNPFC
K56 AVRLKEKKLVKEIIA
K59 LKEKKLVKEIIAVSC
T77 QCQETIRTALAMGAD
N98 VPGAEAENLGPLQVA
K110 QVARVLAKLAEKEKV
K114 VLAKLAEKEKVDLLF
K116 AKLAEKEKVDLLFLG
K116 AKLAEKEKVDLLFLG
T172 EIDGGLETIRLKLPA
K176 GLETIRLKLPAVVTA
K176 GLETIRLKLPAVVTA
T182 LKLPAVVTADLRLNE
Y192 LRLNEPRYATLPNIM
T194 LNEPRYATLPNIMKA
K200 ATLPNIMKAKKKKIE
K200 ATLPNIMKAKKKKIE
K200 ATLPNIMKAKKKKIE
K200 ATLPNIMKAKKKKIE
K202 LPNIMKAKKKKIEVI
K202 LPNIMKAKKKKIEVI
K210 KKKIEVIKAGDLGVD
K210 KKKIEVIKAGDLGVD
K221 LGVDLTSKVSVIsVE
S226-p TSKVSVIsVEEPPQR
L234 VEEPPQRLAGVKVET
K238 PQRLAGVKVETTEDL
T242 AGVKVETTEDLVAKL
K248 TTEDLVAKLKEVGRI
K248 TTEDLVAKLKEVGRI
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