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Protein Page:
OTUB1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
OTUB1 a protease that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occur when T-cell are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Two alternatively spliced isoforms are known. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.2.-; EC 3.4.19.12; EC 3.4.-.-; Ubiquitin-specific protease; Ubiquitin conjugating system; Protease
Cellular Component: cytoplasm
Molecular Function: omega peptidase activity; ubiquitin binding; protein binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity; NEDD8-specific protease activity
Biological Process: immune system process; DNA repair; response to DNA damage stimulus
Reference #:  Q96FW1 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme OTUB1; FLJ20113; FLJ40710; hOTU1; HSPC263; MGC111158; MGC4584; OTB1; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU-domain Ubal-binding 1; OTU1; OTUB1; Otubain-1; Ubiquitin thioesterase OTUB1; ubiquitin-specific protease otubain 1; Ubiquitin-specific-processing protease OTUB1
Gene Symbols: OTUB1
Molecular weight: 31,284 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

OTUB1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S18‑p, Y26‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 7 S16-p QKQEPLGsDsEGVNC
1 3 S18-p QEPLGsDsEGVNCLA
1 1 Y26-p EGVNCLAyDEAIMAQ
0 15 K59-u LELSVLYkEYAEDDN
0 44 K71-u DDNIYQQkIkDLHKK
0 4 K73-u NIYQQkIkDLHKKYS
0 46 K84-u KKYSYIRkTRPDGNC
0 17 K109-u EALLDDSkELQRFKA
0 1 S118 LQRFKAVSAKSKEDL
0 1 S121 FKAVSAKSKEDLVSQ
0 2 K188-a GYLQRESkFFEHFIE
0 2 K188-u GYLQRESkFFEHFIE
0 2 K201 IEGGRTVKEFCQQEV
  mouse

 
S16-p QKQEPLGsDsEGVNC
S18-p QEPLGsDsEGVNCLA
Y26 EGVNCLAYDEAIMAQ
K59-u LELSVLYkEYAEDDN
K71-u DDNIYQQkIKDLHKK
K73 NIYQQkIKDLHKKYS
K84-u KKYSYIRkTRPDGNC
K109-u EALLDDSkELQRFKA
S118-p LQRFKAVsAKsKEDL
S121-p FKAVsAKsKEDLVSQ
K188 GYLQRESKFFEHFIE
K188-u GYLQRESkFFEHFIE
K201-u IEGGRTVkEFCQQEV
  rat

 
S16 QKQEPLGSDSEGVNC
S18 QEPLGSDSEGVNCLA
Y26 EGVNCLAYDEAIMAQ
K59 LELSVLYKEYAEDDN
K71 DDNIYQQKIKDLHKK
K73 NIYQQKIKDLHKKYS
K84 KKYSYIRKTRPDGNC
K109-u EALLDDSkELQRFKA
S118 LQRFKAVSAKSKEDL
S121 FKAVSAKSKEDLVSQ
K188 GYLQRESKFFEHFIE
K188 GYLQRESKFFEHFIE
K201-u IEGGRTVkEFCQQEV
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