a protease that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occur when T-cell are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Two alternatively spliced isoforms are known. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin-specific protease; Protease; EC 18.104.22.168; EC 3.1.2.-; EC 3.4.-.-; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: cytoplasm
Molecular Function: ubiquitin binding; protein binding; omega peptidase activity; ubiquitin protein ligase binding; ubiquitin-specific protease activity; NEDD8-specific protease activity
Biological Process: immune system process; DNA repair; proteolysis; response to DNA damage stimulus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.