Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
OTUB1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
OTUB1 a protease that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occur when T-cell are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Two alternatively spliced isoforms are known. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin-specific protease; Protease; EC 3.4.19.12; EC 3.1.2.-; EC 3.4.-.-; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: cytoplasm
Molecular Function: ubiquitin binding; protein binding; omega peptidase activity; ubiquitin protein ligase binding; ubiquitin-specific protease activity; NEDD8-specific protease activity
Biological Process: immune system process; DNA repair; proteolysis; response to DNA damage stimulus
Reference #:  Q96FW1 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme OTUB1; FLJ20113; FLJ40710; hOTU1; HSPC263; MGC111158; MGC4584; OTB1; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU-domain Ubal-binding 1; OTU1; OTUB1; Otubain-1; Ubiquitin thioesterase OTUB1; ubiquitin-specific protease otubain 1; Ubiquitin-specific-processing protease OTUB1
Gene Symbols: OTUB1
Molecular weight: 31,284 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

OTUB1

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
molecular association, regulation: S18‑p, Y26‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 9 S16-p QKQEPLGsDsEGVNC
1 3 S18-p QEPLGsDsEGVNCLA
1 1 Y26-p EGVNCLAyDEAIMAQ
0 15 K59-ub LELSVLYkEYAEDDN
0 1 Y68-p YAEDDNIyQQkIkDL
0 1 K71 DDNIyQQKIkDLHKK
0 44 K71-ub DDNIyQQkIkDLHKK
0 4 K73-ub NIyQQkIkDLHKKYS
0 46 K84-ub KKYSYIRkTRPDGNC
0 1 K109 EALLDDSKELQRFKA
0 17 K109-ub EALLDDSkELQRFKA
0 1 S118 LQRFKAVSAKSKEDL
0 1 S121 FKAVSAKSKEDLVSQ
0 1 S161-p SVADLLAsFNDQSTS
0 2 K188-ac GYLQRESkFFEHFIE
0 2 K188-ub GYLQRESkFFEHFIE
0 2 K201 IEGGRTVKEFCQQEV
  mouse

 
S16-p QKQEPLGsDsEGVNC
S18-p QEPLGsDsEGVNCLA
Y26 EGVNCLAYDEAIMAQ
K59-ub LELSVLYkEYAEDDN
Y68 YAEDDNIYQQkIKDL
K71-ac DDNIYQQkIKDLHKK
K71-ub DDNIYQQkIKDLHKK
K73 NIYQQkIKDLHKKYS
K84-ub KKYSYIRkTRPDGNC
K109-ac EALLDDSkELQRFKA
K109-ub EALLDDSkELQRFKA
S118-p LQRFKAVsAKsKEDL
S121-p FKAVsAKsKEDLVSQ
S161 SVADLLASFNDQSTS
K188 GYLQRESKFFEHFIE
K188-ub GYLQRESkFFEHFIE
K201-ub IEGGRTVkEFCQQEV
  rat

 
S16 QKQEPLGSDSEGVNC
S18 QEPLGSDSEGVNCLA
Y26 EGVNCLAYDEAIMAQ
K59 LELSVLYKEYAEDDN
Y68 YAEDDNIYQQKIKDL
K71 DDNIYQQKIKDLHKK
K71 DDNIYQQKIKDLHKK
K73 NIYQQKIKDLHKKYS
K84 KKYSYIRKTRPDGNC
K109-ac EALLDDSkELQRFKA
K109-ub EALLDDSkELQRFKA
S118 LQRFKAVSAKSKEDL
S121 FKAVSAKSKEDLVSQ
S161 SVADLLASFNDQSTS
K188-ac GYLQRESkFFEHFIE
K188 GYLQRESKFFEHFIE
K201-ub IEGGRTVkEFCQQEV
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.