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Protein Page:
SYT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SYT1 an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle; Calcium-binding
Chromosomal Location of Human Ortholog: 12cen-q21
Cellular Component: SNARE complex; presynaptic membrane; synaptic vesicle; neuron projection; synaptic vesicle membrane; integral to membrane; plasma membrane; excitatory synapse; cell junction
Molecular Function: protein C-terminus binding; identical protein binding; clathrin binding; calcium-dependent phospholipid binding; transporter activity; calcium ion binding; calcium-dependent protein binding; calmodulin binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; SNARE binding; low-density lipoprotein receptor binding; phosphatidylserine binding; syntaxin-1 binding; phosphatidylinositol binding
Biological Process: regulation of synaptic transmission, glutamatergic; neurotransmitter secretion; positive regulation of vesicle fusion; pathogenesis; positive regulation of synaptic transmission; regulation of exocytosis; positive regulation of calcium ion-dependent exocytosis; synaptic transmission; synaptic vesicle exocytosis; vesicle docking; glutamate secretion; detection of calcium ion; protein homooligomerization
Reference #:  P21579 (UniProtKB)
Alt. Names/Synonyms: DKFZp781D2042; p65; SVP65; synaptotagmin 1; Synaptotagmin I; Synaptotagmin-1; SYT; SYT1; SytI
Gene Symbols: SYT1
Molecular weight: 47,573 Da
Basal Isoelectric point: 8.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SYT1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S24-p TVATVLPsNATEPAS
0 1 K99 KGKEKGGKNAINMKD
0 1 K99 KGKEKGGKNAINMKD
0 5 K105 GKNAINMKDVKDLGK
1 0 T113 DVKDLGKTMKDQALk
0 1 K115 KDLGKTMKDQALkDD
0 2 K120-ub TMKDQALkDDDAEtG
0 2 T126-p LkDDDAEtGLtDGEE
1 12 T129-p DDAEtGLtDGEEkEE
0 1 K134-ub GLtDGEEkEEPKEEE
0 1 K197 KKKKFETKVHRKtLN
0 1 K201 FETKVHRKtLNPVFN
0 2 T202-p ETKVHRKtLNPVFNE
0 1 T212-p PVFNEQFtFKVPySE
0 1 K214 FNEQFtFKVPySELG
0 1 K214 FNEQFtFKVPySELG
0 1 Y217-p QFtFKVPySELGGKT
0 1 T224 ySELGGKTLVMAVyD
0 33 Y230-p KTLVMAVyDFDRFSk
0 1 S236 VyDFDRFSkHDIIGE
0 1 K237-ac yDFDRFSkHDIIGEF
0 1 K237 yDFDRFSKHDIIGEF
0 2 S265 EEWRDLQSAEKEEQE
0 1 K268 RDLQSAEKEEQEKLG
0 2 K268 RDLQSAEKEEQEKLG
0 1 K298 TVVILEAKNLKkMDV
0 1 K302-ac LEAKNLKkMDVGGLS
0 41 Y312-p VGGLSDPyVKIHLMQ
0 3 K333-ub KKKTTIKkNTLNPYY
0 1 S343 LNPYYNESFSFEVPF
0 2 S345 PYYNESFSFEVPFEQ
0 6 Y365 VVVTVLDYDKIGKND
0 1 K370 LDYDKIGKNDAIGKV
0 1 K376 GKNDAIGKVFVGYNS
0 106 Y381 IGKVFVGYNSTGAEL
  mouse

► Hide Isoforms
 
H23 TVATLVPHNATEPAS
K98 KGKEKGGKNAINMkD
K98 KGKEKGGKNAINMkD
K104-ub GKNAINMkDVKDLGK
T112 DVKDLGKTMKDQALk
K114 KDLGKTMKDQALkDD
K119-ub TMKDQALkDDDAEtG
T125-p LkDDDAEtGLtDGEE
T128-p DDAEtGLtDGEEKEE
K133 GLtDGEEKEEPKEEE
K196 KKKKFETKVHRktLN
K200-ub FETKVHRktLNPVFN
T201-p ETKVHRktLNPVFNE
T211 PVFNEQFTFkVPYSE
K213 FNEQFTFKVPYSELG
K213-ub FNEQFTFkVPYSELG
Y216 QFTFkVPYSELGGKt
T223-p YSELGGKtLVMAVyD
Y229-p KtLVMAVyDFDRFsk
S235-p VyDFDRFskHDIIGE
K236 yDFDRFsKHDIIGEF
K236-ub yDFDRFskHDIIGEF
S264-p EEWRDLQsAEkEEQE
K267 RDLQsAEKEEQEKLG
K267-ub RDLQsAEkEEQEKLG
K297-ub TVVILEAkNLKKMDV
K301 LEAkNLKKMDVGGLS
Y311-p VGGLSDPyVKIHLMQ
K332-ub KKKTTIKkNTLNPYY
S342 LNPYYNESFsFEVPF
S344-p PYYNESFsFEVPFEQ
Y364 VVVTVLDYDKIGkND
K369-ub LDYDKIGkNDAIGkV
K375-ub GkNDAIGkVFVGyNS
Y380-p IGkVFVGyNSTGAEL
  SYT1 iso2  
H23 TVATLVPHNATEPAS
K98 KGKEKGGKNAINMKD
K98 KGKEKGGKNAINMKD
K104 GKNAINMKDVKDLGK
T112 DVKDLGKTMkDQDDD
K114-ub KDLGKTMkDQDDDAE
- gap
T122 DQDDDAETGLtDGEE
T125-p DDAETGLtDGEEKEE
K130 GLtDGEEKEEPKEEE
K193 KKKKFETKVHRKTLN
K197 FETKVHRKTLNPVFN
T198 ETKVHRKTLNPVFNE
T208 PVFNEQFTFKVPYSE
K210 FNEQFTFKVPYSELG
K210 FNEQFTFKVPYSELG
Y213 QFTFKVPYSELGGKT
T220 YSELGGKTLVMAVYD
Y226 KTLVMAVYDFDRFSK
S232 VYDFDRFSKHDIIGE
K233 YDFDRFSKHDIIGEF
K233 YDFDRFSKHDIIGEF
S261 EEWRDLQSAEKEEQE
K264 RDLQSAEKEEQEKLG
K264 RDLQSAEKEEQEKLG
K294 TVVILEAKNLKKMDV
K298 LEAKNLKKMDVGGLS
Y308 VGGLSDPYVKIHLMQ
K329 KKKTTIKKNTLNPYY
S339 LNPYYNESFSFEVPF
S341 PYYNESFSFEVPFEQ
Y361 VVVTVLDYDKIGKND
K366 LDYDKIGKNDAIGKV
K372 GKNDAIGKVFVGYNS
Y377 IGKVFVGYNSTGAEL
  rat

 
H23 TVATLVPHNATEPAS
K98-ac KGKEKGGkNAINMkD
K98-ub KGKEKGGkNAINMkD
K104-ub GkNAINMkDVKDLGK
T112-p DVKDLGKtMKDQALK
K114 KDLGKtMKDQALKDD
K119 tMKDQALKDDDAETG
T125 LKDDDAETGLtDGEE
T128-p DDAETGLtDGEEKEE
K133 GLtDGEEKEEPKEEE
K196-ub KKKKFETkVHRKTLN
K200 FETkVHRKTLNPVFN
T201 ETkVHRKTLNPVFNE
T211 PVFNEQFTFkVPYSE
K213-ac FNEQFTFkVPYSELG
K213 FNEQFTFKVPYSELG
Y216 QFTFkVPYSELGGKT
T223 YSELGGKTLVMAVyD
Y229-p KTLVMAVyDFDRFSK
S235 VyDFDRFSKHDIIGE
K236 yDFDRFSKHDIIGEF
K236 yDFDRFSKHDIIGEF
S264 EEWRDLQSAEkEEQE
K267-ac RDLQSAEkEEQEKLG
K267 RDLQSAEKEEQEKLG
K297 TVVILEAKNLKKMDV
K301 LEAKNLKKMDVGGLS
Y311-p VGGLSDPyVKIHLMQ
K332 KKKTTIKKNTLNPYY
S342-p LNPYYNEsFsFEVPF
S344-p PYYNEsFsFEVPFEQ
Y364-p VVVTVLDyDKIGKND
K369 LDyDKIGKNDAIGKV
K375 GKNDAIGKVFVGyNS
Y380-p IGKVFVGyNSTGAEL
  cow

 
H24 TVATVLPHNATEPAS
K99 KGKEKGGKNAINMKD
K99 KGKEKGGKNAINMKD
K105 GKNAINMKDVKDLGK
T113 DVKDLGKTMKDQALK
K115 KDLGKTMKDQALKDD
K120 TMKDQALKDDDAETG
T126 LKDDDAETGLtDGEE
T129-p DDAETGLtDGEEKEE
K134 GLtDGEEKEEPKEEE
K197 KKKKFETKVHRKTLN
K201 FETKVHRKTLNPVFN
T202 ETKVHRKTLNPVFNE
T212 PVFNEQFTFKVPYSE
K214 FNEQFTFKVPYSELG
K214 FNEQFTFKVPYSELG
Y217 QFTFKVPYSELGGKT
T224 YSELGGKTLVMAVYD
Y230 KTLVMAVYDFDRFSK
S236 VYDFDRFSKHDIIGE
K237 YDFDRFSKHDIIGEF
K237 YDFDRFSKHDIIGEF
S265 EEWRDLQSAEKEEQE
K268 RDLQSAEKEEQEKLG
K268 RDLQSAEKEEQEKLG
K298 TVVILEAKNLKKMDV
K302 LEAKNLKKMDVGGLS
Y312 VGGLSDPYVKIHLMQ
K333 KKKTTIKKNTLNPYY
S343 LNPYYNESFSFEVPF
S345 PYYNESFSFEVPFEQ
Y365 VVVTVLDYDKIGKND
K370 LDYDKIGKNDAIGKV
K376 GKNDAIGKVFVGYNS
Y381 IGKVFVGYNSTGAEL
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