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Protein Page:
GLDC (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GLDC The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Defects in GLDC are a cause of non-ketotic hyperglycinemia (NKH); also known as glycine encephalopathy (GCE). NKH is an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms. Belongs to the GcvP family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; EC 1.4.4.2
Cellular Component: mitochondrion
Molecular Function: glycine dehydrogenase (decarboxylating) activity; electron carrier activity; lyase activity; pyridoxal phosphate binding
Biological Process: glycine catabolic process
Reference #:  P23378 (UniProtKB)
Alt. Names/Synonyms: GCE; GCSP; GLDC; Glycine cleavage system P protein; glycine cleavage system protein P; Glycine decarboxylase; glycine decarboxylase P-protein; glycine dehydrogenase (decarboxylating); Glycine dehydrogenase [decarboxylating], mitochondrial; HYGN1; MGC138198; MGC138200
Gene Symbols: GLDC
Molecular weight: 112,730 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GLDC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 D36-ca CWAPRSRdSssGGGD
0 1 S38-p APRSRdSssGGGDSA
0 1 S39-p PRSRdSssGGGDSAA
0 12 K73 RHIGPGDKDQREMLQ
0 1 K447 IQCGCSVKEVLGRAA
0 26 K514-a GIPGSVFkRTSPFLT
0 1 K514 GIPGSVFKRTSPFLT
0 2 Y537-p SETNIVRyMKKLENK
0 6 K636 IRAYLNQKGEGHRTV
0 1 K636 IRAYLNQKGEGHRTV
0 2 K648-a RTVCLIPkSAHGTNP
0 1 K827 MMGGKGLKQATETAI
0 2 Y839-p TAILNANyMAKRLET
0 12 K871-a ILDTRPFkkSANIEA
0 3 K872-a LDTRPFkkSANIEAV
0 1 K872 LDTRPFkKSANIEAV
  mouse

 
D36 SWAQRSRDSSGGGGG
S38 AQRSRDSSGGGGGGG
G39 QRSRDSSGGGGGGGG
K78-a RHIGPGDkDRREMLQ
K452-a VQCGCSVkEVLGRAA
K519-a GLLGSSFkRTSPFLT
K519-u GLLGSSFkRTSPFLT
Y542 SETNLVRYMKKLENK
K641-a IRAYLDQkGERHRTV
K641-u IRAYLDQkGERHRTV
K653-a RTVCLIPkSAHGTNP
K832-u MMGGKGLkEATEIAI
Y844 IAILNANYMAKRLEK
K876-a ILDTRPFkkSANVEA
K877-a LDTRPFkkSANVEAV
K877-u LDTRPFkkSANVEAV
  rat

 
D36 SWAPRSRDSSSGGGG
S38 APRSRDSSSGGGGGG
S39 PRSRDSSSGGGGGGG
K77 RHIGPGDKDRREMLQ
K425 VQCGCSLKEVLGRAA
K492 GLLGSSFKRTSPFLT
K492 GLLGSSFKRTSPFLT
Y515 SETNLVRYMKKLENK
K600 IRAYLDQKGERHRTV
K600 IRAYLDQKGERHRTV
K612 RTVCLIPKSAHGTNP
K706 MMGGKGLKEATEIAI
Y718 IAILNANYMAKRLER
K747 ILDTRPFKKSANIEA
K748 LDTRPFKKSANIEAV
K748 LDTRPFKKSANIEAV
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