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Protein Page:
ATG7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATG7 Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3. Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. Belongs to the ATG7 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Autophagy
Cellular Component: cytoplasm; axoneme; cytosol
Molecular Function: protein binding; protein homodimerization activity; APG8 activating enzyme activity; APG12 activating enzyme activity; ubiquitin activating enzyme activity; transcription factor binding
Biological Process: regulation of protein ubiquitination; positive regulation of apoptosis; protein ubiquitination; pyramidal neuron development; adult walking behavior; post-embryonic development; protein transport; cardiac muscle cell development; protein amino acid lipidation; protein catabolic process; positive regulation of autophagy; amino acid metabolic process; central nervous system neuron axonogenesis; organelle organization and biogenesis; cerebellar Purkinje cell layer development; protein modification process; C-terminal protein lipidation; cellular response to starvation; liver development; cellular response to nitrogen starvation; neurological system process; protein modification by small protein conjugation; positive regulation of protein catabolic process; mitochondrion degradation; positive regulation of protein modification process; cerebral cortex development; positive regulation of macroautophagy; negative regulation of apoptosis
Reference #:  O95352 (UniProtKB)
Alt. Names/Synonyms: APG7 autophagy 7-like; APG7-like; APG7L; ATG7; ATG7 autophagy related 7 homolog (S. cerevisiae); Autophagy-related protein 7; DKFZp434N0735; GSA7; hAGP7; ubiquitin activating enzyme E1-like protein; Ubiquitin-activating enzyme E1-like protein
Gene Symbols: ATG7
Molecular weight: 77,960 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATG7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y38-p TQKKLNEyRLDEAPK
0 1 S295 KLPEMAFSPDCPKAV
0 1 K306-ac PKAVGWEkNQKGGMG
0 1 K423 AAADRLQKIFPGVNA
0 1 S480 LLMDTRESRWLPAVI
0 2 S490-p LPAVIAAsKRKLVIN
0 1 Y551 PGYKLGCYFCNDVVA
0 2 S698-p AAEIWDMsDDETI__
0 1 T702 WDMsDDETI______
  ATG7 iso3  
Y38 TQKKLNEYRLDEAPK
S256 KLPEMAFSPDCPKAV
K267 PKAVGWEKNQKGGMG
K384 AAADRLQKIFPGVNA
S441 LLMDTRESRWLPAVI
S451 LPAVIAASKRKLVIN
Y512 PGYKLGCYFCNDVVA
S618-p SSKIWDMsDDEtI__
T622-p WDMsDDEtI______
  mouse

 
Y34 TQKKLNEYRLDEAPK
S291-p KLPEMAFsPDCPKAV
K302 PKAVGWEKNQKGGMG
K419-ub AAAERLQkIFPGVNA
S476-p LLMDTREsRWLPTVI
S486-p LPTVIAAsKRKLVIN
Y546-p PGYKLGCyFCNDVVA
S693 AAEIWDMSDEETV__
T697 WDMSDEETV______
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