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ATG7 (human)

Overview ATG7 Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3. Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. Belongs to the ATG7 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Ubiquitin conjugating system; Autophagy Cellular Component: cytoplasm Molecular Function: protein binding; protein homodimerization activity; APG12 activating enzyme activity; nucleotide binding; ubiquitin activating enzyme activity Biological Process: amino acid metabolic process; central nervous system neuron axonogenesis; regulation of protein ubiquitination; organelle organization and biogenesis; cerebellar Purkinje cell layer development; protein modification process; pyramidal neuron development; liver development; adult walking behavior; neurological system process; post-embryonic development; response to starvation; membrane fusion; protein transport; cardiac muscle cell development; protein modification by small protein conjugation; protein amino acid lipidation; positive regulation of protein modification process; autophagy; protein catabolic process; cerebral cortex development; positive regulation of macroautophagy; negative regulation of apoptosis Reference #:  O95352 (UniProtKB) Alt. Names/Synonyms: APG7 autophagy 7-like; APG7-like; APG7L; ATG7; ATG7 autophagy related 7 homolog (S. cerevisiae); Autophagy-related protein 7; DKFZp434N0735; GSA7; hAGP7; ubiquitin activating enzyme E1-like protein; Ubiquitin-activating enzyme E1-like protein Gene Symbols: ATG7 Molecular weight: 77,960 Da Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states CST Pathways:  Autophagy Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATG7

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y38-p	TQKKLNEyRLDEAPK
0	1		Y50-p	APKDIKGyYyNGDSA
0	1		Y52-p	KDIKGyYyNGDSAGL
0	1		S295	KLPEMAFSPDCPKAV
0	1		K306-a	PKAVGWEkNQKGGMG
0	1		K423	AAADRLQKIFPGVNA
0	1		S480	LLMDTRESRWLPAVI
0	2		S490-p	LPAVIAAsKRKLVIN
0	1		Y551	PGYKLGCYFCNDVVA

	mouse
Y34	TQKKLNEYRLDEAPK
Y46	APKDIKGYYYNGDSA
Y48	KDIKGYYYNGDSAGL
S291-p	KLPEMAFsPDCPKAV
K302	PKAVGWEKNQKGGMG
K419-u	AAAERLQkIFPGVNA
S476-p	LLMDTREsRWLPTVI
S486-p	LPTVIAAsKRKLVIN
Y546-p	PGYKLGCyFCNDVVA

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