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Protein Page:
PRDM5 (human)

Overview
PRDM5 Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. Defects in PRDM5 are the cause of Brittle cornea syndrome type 2 (BCS2). A disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobile joints. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Transcription factor
Cellular Component: nucleus
Molecular Function: methyltransferase activity; protein binding; sequence-specific DNA binding; metal ion binding
Biological Process: transcription, DNA-dependent; histone deacetylation; mitotic cell cycle; negative regulation of transcription, DNA-dependent; histone H3-K9 methylation
Reference #:  Q9NQX1 (UniProtKB)
Alt. Names/Synonyms: PFM2; PR domain containing 5; PR domain zinc finger protein 5; PR domain-containing protein 5; PRDM5
Gene Symbols: PRDM5
Molecular weight: 73,090 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
Select Structure to View Below

PRDM5

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S331-p ECMKKFIsANQLKRH
  mouse

 
S300 ECMKKFISANQLKRH
  rat

 
S393 ECMKKFISANQLKRH
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