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Protein Page:
PRDM5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PRDM5 Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. Defects in PRDM5 are the cause of Brittle cornea syndrome type 2 (BCS2). A disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobile joints. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Methyltransferase, protein lysine, predicted; C2H2-type zinc finger protein; Transcription factor
Cellular Component: nucleus
Molecular Function: methyltransferase activity; protein binding; sequence-specific DNA binding; metal ion binding
Biological Process: transcription, DNA-dependent; histone deacetylation; mitotic cell cycle; negative regulation of transcription, DNA-dependent; histone H3-K9 methylation
Reference #:  Q9NQX1 (UniProtKB)
Alt. Names/Synonyms: PFM2; PR domain containing 5; PR domain zinc finger protein 5; PR domain-containing protein 5; PRDM5
Gene Symbols: PRDM5
Molecular weight: 73,090 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
Select Structure to View Below

PRDM5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y69-p GSKGEVLyILDATNP
0 1 S153-p VENSRRQsTAGRKDR
0 1 S231-p KSSLKESsRSFQCSV
0 1 K265-ac GDARFVCkADSCGKR
0 2 S331-p ECMKKFIsANQLkRH
0 1 K336-ac FIsANQLkRHMITHS
0 1 S500-p YCGQKFAssGtLRVH
0 1 S501-p CGQKFAssGtLRVHI
0 1 T503-p QKFAssGtLRVHIRS
0 1 T612-p QFCHKKFtRNDYLKV
  mouse

 
Y69 GSKGEVLYILDATNP
L153 VDHSKGQLAAGSKGH
- gap
K234 GEARFVCKADSCGKR
S300 ECMKKFISANQLKRH
K305 FISANQLKRHMITHS
S469 YCGQKFASSGTLRVH
S470 CGQKFASSGTLRVHI
T472 QKFASSGTLRVHIRS
T581 HFCHKKFTRNDYLKV
  rat

 
Y162 GSKGEVLYILDATNP
L246 VDHSKGQLAAGSKGH
- gap
K327 GDARFVCKVDSCGKR
S393 ECMKKFISANQLKRH
K398 FISANQLKRHMITHS
S562 YCGQKFASSGTLRVH
S563 CGQKFASSGTLRVHI
T565 QKFASSGTLRVHIRS
T674 HFCHKKFTRNDYLKV
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