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Protein Page:
ACE2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ACE2 Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.17.-; Membrane protein, integral; Protease; EC 3.4.17.23
Cellular Component: extracellular space; cell surface; extracellular region; integral to membrane; plasma membrane; lipid raft
Molecular Function: peptidyl-dipeptidase activity; viral receptor activity; protein binding; carboxypeptidase activity; zinc ion binding; metallopeptidase activity; peptide hormone binding; endopeptidase activity; glycoprotein binding
Biological Process: virion attachment, binding of host cell surface receptor; entry of virus into host cell; regulation of vasodilation; response to virus; angiotensin maturation; proteolysis; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of cell proliferation; regulation of cytokine production; cellular protein metabolic process; regulation of vasoconstriction; angiotensin catabolic process in blood; regulation of inflammatory response; receptor biosynthetic process; angiotensin mediated drinking behavior
Reference #:  Q9BYF1 (UniProtKB)
Alt. Names/Synonyms: ACE-related carboxypeptidase; ACE2; ACEH; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; DKFZp434A014; Metalloprotease MPROT15; Processed angiotensin-converting enzyme 2
Gene Symbols: ACE2
Molecular weight: 92,463 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACE2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2-p ______MsSSSWLLL
0 1 S10-p SSSWLLLsLVAVTAA
0 1 S128-p NTMSTIYstGKVCNP
0 1 T129-p TMSTIYstGKVCNPD
0 1 Y215 EVNGVDGYDYSRGQL
0 2 S545-p PLHKCDIsNstEAGQ
0 2 S547-p HKCDIsNstEAGQKL
0 2 T548-p KCDIsNstEAGQKLF
0 1 K577 LENVVGAKNMNVRPL
0 1 S692-p VTAPKNVsDIIPRTE
0 3 K770-ac TGIRDRKkkNkARSG
0 3 K771-ac GIRDRKkkNkARSGE
0 3 K773-ac RDRKkkNkARSGENP
0 11 Y781-p ARSGENPyAsIDISK
0 2 S783-p SGENPyAsIDISKGE
  mouse

 
S2 ______MSSSSWLLL
S10 SSSWLLLSLVAVTTA
S128 NTMSTIYSTGKVCNP
T129 TMSTIYSTGKVCNPK
Y215-p EAEGADGyNYNRNQL
S545-p SLHKCDIsNstEAGQ
S547-p HKCDIsNstEAGQKL
T548-p KCDIsNstEAGQKLL
R577-m2 LENVVGArNMDVKPL
S692 VTSPQNVSDVIPRSE
K770 TGIKGRKKKNETKRE
K771 GIKGRKKKNETKREE
E773 KGRKKKNETKREENP
Y781 TKREENPYDSMDIGK
S783 REENPYDSMDIGKGE
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