Home

POLR2D (human)

Overview POLR2D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Belongs to the eukaryotic RPB4 RNA polymerase subunit family. Note: This description may include information from UniProtKB. Protein type: RNA processing; Transcription initiation complex; Nucleotide Metabolism - purine; Transferase; Nucleotide Metabolism - pyrimidine; EC 2.7.7.6 Cellular Component: nucleoplasm; DNA-directed RNA polymerase II, core complex; nucleus Molecular Function: DNA-directed RNA polymerase activity; nucleotide binding; protein kinase activity Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA splicing; DNA repair; protein amino acid phosphorylation; nuclear mRNA splicing, via spliceosome; mRNA capping; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; gene expression Reference #:  O15514 (UniProtKB) Alt. Names/Synonyms: DNA-directed RNA polymerase II 16 kDa polypeptide; DNA-directed RNA polymerase II subunit D; DNA-directed RNA polymerase II subunit RPB4; HSRBP4; HSRPB4; POLR2D; polymerase (RNA) II (DNA directed) polypeptide D; RBP4; RNA polymerase II 16 kDa subunit; RNA polymerase II subunit B4; RNA polymerase II subunit hsRBP4; RPB16; RPB4 Gene Symbols: POLR2D Molecular weight: 16,311 Da Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states CST Pathways:  Protein Acetylation

Select Structure to View Below POLR2D 2C35 - A/C/E/G=1-142 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y67-p	VFMKTLNyTARFSRF
0	1		K137-u	ILDDIQTkRSFQY__

	mouse
Y67	VFMKTLNYTARFSRF
K137	ILDDIQTKRSFQY__

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.