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CREB (mouse)

Overview CREB a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: transcription factor complex; mitochondrion; nuclear chromatin; chromatin; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity; transcription factor binding Biological Process: transcription from RNA polymerase II promoter; response to drug; lactation; protein stabilization; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of hormone secretion; positive regulation of multicellular organism growth; positive regulation of lipid biosynthetic process; regulation of circadian rhythm; protein amino acid phosphorylation; regulation of apoptosis; response to organic substance; mammary gland development; axonogenesis; regulation of transcription, DNA-dependent; pituitary gland development; transforming growth factor beta receptor signaling pathway; positive regulation of transforming growth factor-beta3 production; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcriptional preinitiation complex assembly; cell differentiation; regulation of cell size Reference #:  Q01147 (UniProtKB) Alt. Names/Synonyms: 2310001E10Rik; 3526402H21Rik; AV083133; cAMP responsive element binding protein 1; cAMP-responsive element-binding protein 1; Creb; CREB-1; Creb1; Cyclic AMP-responsive element-binding protein 1 Gene Symbols: Creb1 Molecular weight: 36,674 Da Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  MAPK/Erk in Growth and Differentiation  |  Parkinson's Disease  |  Signaling Pathways Activating p38 MAPK  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CREB 1DH3 - A/C=285-339 (mouse) 1KDX - B=119-146 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: S133‑p signaling pathway regulation: S133‑p transcription, altered: S133‑p, S142‑p activation: S133‑p, S142‑p intracellular localization: S121‑p molecular association, regulation: S133‑p phosphorylation: S133‑p protein conformation: S133‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
1	0		K91	QTVQSSCKDLKRLFs
1	0		K94	QSSCKDLKRLFsGtQ
2	0		S98-p	KDLKRLFsGtQISTI
3	0		T100-p	LKRLFsGtQISTIAE
6	1		S108-p	QISTIAEsEDsQEsV
7	4		S111-p	TIAEsEDsQEsVDsV
6	1		S114-p	EsEDsQEsVDsVTDs
4	0		S117-p	DsQEsVDsVTDsQKR
1	1		T119	QEsVDsVTDsQKRRE
9	0		S121-p	sVDsVTDsQKRREIL
10	2		S129-p	QKRREILsRRPsYRk
207	63		S133-p	EILsRRPsYRkILND
0	4		Y134	ILsRRPsYRkILNDL
2	0		K136-a	sRRPsYRkILNDLss
0	2		K136-u	sRRPsYRkILNDLss
10	9		S142-p	RkILNDLssDAPGVP
4	1		S143-p	kILNDLssDAPGVPR
2	0		S156-p	PRIEEEKsEEETSAP
0	1		S270-p	APGVVMAssPALPTQ
2	2		S271-p	PGVVMAssPALPTQP
1	0		K285	PAEEAARKREVRLMK
1	0		K304	ARECRRKKKEYVKCL
0	2		K330-u	KTLIEELkALKDLYC
1	1		S340-p	KDLYCHKsD______

	human
K91	QTVQSSCKDLKRLFs
K94	QSSCKDLKRLFsGtQ
S98-p	KDLKRLFsGtQISTI
T100-p	LKRLFsGtQISTIAE
S108-p	QISTIAEsEDsQEsV
S111-p	TIAEsEDsQEsVDsV
S114-p	EsEDsQEsVDsVtDs
S117-p	DsQEsVDsVtDsQKR
T119-p	QEsVDsVtDsQKRRE
S121-p	sVDsVtDsQKRREIL
S129-p	QKRREILsRRPsyRk
S133-p	EILsRRPsyRkILND
Y134-p	ILsRRPsyRkILNDL
K136	sRRPsyRKILNDLss
K136-u	sRRPsyRkILNDLss
S142-p	RkILNDLssDAPGVP
S143-p	kILNDLssDAPGVPR
S156-p	PRIEEEKsEEETSAP
S270	APGVVMASsPALPTQ
S271-p	PGVVMASsPALPTQP
K285-s	PAEEAARkREVRLMK
K304-s	ARECRRKkKEYVKCL
K330-u	KTLIEELkALKDLYC
S340-p	KDLYCHKsD______

	rat
K91-a	QTVQSSCkDLkRLFS
K94-a	QSSCkDLkRLFSGTQ
S98	kDLkRLFSGTQISTI
T100	LkRLFSGTQISTIAE
S108-p	QISTIAEsEDsQEsV
S111-p	TIAEsEDsQEsVDsV
S114-p	EsEDsQEsVDsVtDs
S117-p	DsQEsVDsVtDsQKR
T119-p	QEsVDsVtDsQKRRE
S121-p	sVDsVtDsQKRREIL
S129-p	QKRREILsRRPsYRk
S133-p	EILsRRPsYRkILND
Y134	ILsRRPsYRkILNDL
K136-a	sRRPsYRkILNDLss
K136	sRRPsYRKILNDLss
S142-p	RkILNDLssDAPGVP
S143-p	kILNDLssDAPGVPR
S156	PRIEEEKSEEETSAP
S270	APGVVMASSPALPTQ
S271	PGVVMASSPALPTQP
K285	PAEEAARKREVRLMK
K304	ARECRRKKKEYVKCL
K330	KTLIEELKALKDLYC
S340	KDLYCHKSD______

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