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Protein Page:
CREB (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CREB a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: transcription factor complex; mitochondrion; nuclear chromatin; chromatin; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; histone acetyltransferase binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; lactation; circadian rhythm; response to glucagon stimulus; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; rhythmic process; positive regulation of multicellular organism growth; protein amino acid phosphorylation; response to organic substance; regulation of apoptosis; mammary gland development; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; positive regulation of transforming growth factor-beta3 production; positive regulation of transcriptional preinitiation complex assembly; cell differentiation; response to drug; transcription, DNA-dependent; protein stabilization; secretory granule organization and biogenesis; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; regulation of circadian rhythm; memory; axonogenesis; pituitary gland development; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell size
Reference #:  Q01147 (UniProtKB)
Alt. Names/Synonyms: 2310001E10Rik; 3526402H21Rik; AV083133; cAMP responsive element binding protein 1; cAMP-responsive element-binding protein 1; Creb; CREB-1; Creb1; Cyclic AMP-responsive element-binding protein 1
Gene Symbols: Creb1
Molecular weight: 36,674 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Parkinson's Disease  |  Regulation of P38 MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CREB

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S133‑p
signaling pathway regulation: S133‑p
transcription, altered: S133‑p, S142‑p
transcription, induced: S133‑p
activity, induced: S133‑p, S142‑p
intracellular localization: S121‑p
molecular association, regulation: S133‑p
phosphorylation: S133‑p
protein conformation: S133‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 K91 QTVQSSCKDLKRLFs
1 0 K94 QSSCKDLKRLFsGtQ
2 0 S98-p KDLKRLFsGtQISTI
3 0 T100-p LKRLFsGtQISTIAE
7 1 S108-p QISTIAEsEDsQEsV
8 4 S111-p TIAEsEDsQEsVDsV
7 1 S114-p EsEDsQEsVDsVTDs
4 0 S117-p DsQEsVDsVTDsQKR
1 1 T119 QEsVDsVTDsQKRRE
10 0 S121-p sVDsVTDsQKRREIL
10 2 S129-p QKRREILsRRPsYRk
217 63 S133-p EILsRRPsYRkILND
0 4 Y134 ILsRRPsYRkILNDL
2 0 K136-ac sRRPsYRkILNDLss
0 2 K136-ub sRRPsYRkILNDLss
10 11 S142-p RkILNDLssDAPGVP
4 1 S143-p kILNDLssDAPGVPR
2 0 S156-p PRIEEEKsEEETSAP
0 1 S260-p QIRTAPTstIAPGVV
0 1 T261-p IRTAPTstIAPGVVM
1 1 S270-p APGVVMAssPALPTQ
3 5 S271-p PGVVMAssPALPTQP
1 0 K285 PAEEAARKREVRLMK
1 0 K304 ARECRRKKKEYVKCL
0 2 K330-ub KTLIEELkALKDLYC
1 1 S340-p KDLYCHKsD______
4095 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Biotinylated)
4276 : Phospho-CREB (Ser133) (D1G6) Rabbit mAb
9187 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9191 : Phospho-CREB (Ser133) Antibody
9196 : Phospho-CREB (Ser133) (1B6) Mouse mAb
9198 : Phospho-CREB (Ser133) (87G3) Rabbit mAb
14228 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (PE Conjugate)
  human

► Hide Isoforms
 
K91 QTVQSSCKDLKRLFs
K94 QSSCKDLKRLFsGtQ
S98-p KDLKRLFsGtQISTI
T100-p LKRLFsGtQISTIAE
S108-p QISTIAEsEDsQEsV
S111-p TIAEsEDsQEsVDsV
S114-p EsEDsQEsVDsVtDs
S117-p DsQEsVDsVtDsQKR
T119-p QEsVDsVtDsQKRRE
S121-p sVDsVtDsQKRREIL
S129-p QKRREILsRRPsyRk
S133-p EILsRRPsyRkILND
Y134-p ILsRRPsyRkILNDL
K136 sRRPsyRKILNDLss
K136-ub sRRPsyRkILNDLss
S142-p RkILNDLssDAPGVP
S143-p kILNDLssDAPGVPR
S156-p PRIEEEKsEEETSAP
S260 QIRTAPTSTIAPGVV
T261 IRTAPTSTIAPGVVM
S270-p APGVVMAssPALPTQ
S271-p PGVVMAssPALPTQP
K285-sm PAEEAARkREVRLMK
K304-sm ARECRRKkKEYVKCL
K330-ub KTLIEELkALKDLYC
S340-p KDLYCHKsD______
4095 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Biotinylated)
4276 : Phospho-CREB (Ser133) (D1G6) Rabbit mAb
9187 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9191 : Phospho-CREB (Ser133) Antibody
9196 : Phospho-CREB (Ser133) (1B6) Mouse mAb
9198 : Phospho-CREB (Ser133) (87G3) Rabbit mAb
14228 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (PE Conjugate)
  CREB iso2  
- gap
- gap
- gap
- gap
S94 QISTIAESEDSQESV
S97 TIAESEDSQESVDSV
S100 ESEDSQESVDSVTDS
S103 DSQESVDSVTDSQKR
T105 QESVDSVTDSQKRRE
S107 SVDSVTDSQKRREIL
S115 QKRREILSRRPSYRK
S119 EILSRRPSYRKILND
Y120 ILSRRPSYRKILNDL
K122 SRRPSYRKILNDLSS
K122 SRRPSYRKILNDLSS
S128 RKILNDLSSDAPGVP
S129 KILNDLSSDAPGVPR
S142 PRIEEEKSEEETSAP
S246 QIRTAPTSTIAPGVV
T247 IRTAPTSTIAPGVVM
S256 APGVVMASSPALPTQ
S257 PGVVMASSPALPTQP
K271 PAEEAARKREVRLMK
K290 ARECRRKKKEYVKCL
K316 KTLIEELKALKDLYC
S326 KDLYCHKSD______
  rat

 
K91-ac QTVQSSCkDLkRLFS
K94-ac QSSCkDLkRLFSGTQ
S98 kDLkRLFSGTQISTI
T100 LkRLFSGTQISTIAE
S108-p QISTIAEsEDsQEsV
S111-p TIAEsEDsQEsVDsV
S114-p EsEDsQEsVDsVtDs
S117-p DsQEsVDsVtDsQKR
T119-p QEsVDsVtDsQKRRE
S121-p sVDsVtDsQKRREIL
S129-p QKRREILsRRPsYRk
S133-p EILsRRPsYRkILND
Y134 ILsRRPsYRkILNDL
K136-ac sRRPsYRkILNDLss
K136 sRRPsYRKILNDLss
S142-p RkILNDLssDAPGVP
S143-p kILNDLssDAPGVPR
S156 PRIEEEKSEEETSAP
S260 QIRTAPTSTIAPGVV
T261 IRTAPTSTIAPGVVM
S270 APGVVMASSPALPTQ
S271 PGVVMASSPALPTQP
K285 PAEEAARKREVRLMK
K304 ARECRRKKKEYVKCL
K330 KTLIEELKALKDLYC
S340 KDLYCHKSD______
4095 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Biotinylated)
4276 : Phospho-CREB (Ser133) (D1G6) Rabbit mAb
9187 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9191 : Phospho-CREB (Ser133) Antibody
9196 : Phospho-CREB (Ser133) (1B6) Mouse mAb
9198 : Phospho-CREB (Ser133) (87G3) Rabbit mAb
14228 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (PE Conjugate)
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