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Protein Page:
CREB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CREB a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Chromosomal Location of Human Ortholog: 2q34
Cellular Component: nucleoplasm; transcription factor complex; nucleolus; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; transcription cofactor activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; lactation; circadian rhythm; axon guidance; response to glucagon stimulus; viral reproduction; nerve growth factor receptor signaling pathway; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; positive regulation of multicellular organism growth; toll-like receptor 3 signaling pathway; signal transduction; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; response to organic substance; synaptic transmission; toll-like receptor 4 signaling pathway; epidermal growth factor receptor signaling pathway; response to drug; Notch signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; protein stabilization; secretory granule organization and biogenesis; MyD88-independent toll-like receptor signaling pathway; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; phospholipase C activation; pituitary gland development; toll-like receptor signaling pathway; innate immune response; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; regulation of cell size
Reference #:  P16220 (UniProtKB)
Alt. Names/Synonyms: active transcription factor CREB; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB-1; CREB1; Cyclic AMP-responsive element-binding protein 1; MGC9284; transactivator protein
Gene Symbols: CREB1
Molecular weight: 36,688 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Parkinson's Disease  |  Regulation of P38 MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CREB

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S133‑p
cell differentiation, altered: S133‑p
cell growth, induced: S129‑p, S133‑p
cell motility, altered: S133‑p
transcription, altered: S133‑p
transcription, induced: S129‑p, S133‑p, S271‑p
transcription, inhibited: T100‑p, S111‑p, S121‑p
activity, induced: S133‑p
activity, inhibited: T100‑p, S111‑p, S121‑p
molecular association, regulation: S108‑p, S111‑p, S114‑p, S121‑p, S129‑p, S133‑p, S271‑p
phosphorylation: T100‑p, S108‑p, S111‑p, S114‑p, S117‑p, S133‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 K91 QTVQSSCKDLKRLFs
1 0 K94 QSSCKDLKRLFsGtQ
2 0 S98-p KDLKRLFsGtQISTI
3 0 T100-p LKRLFsGtQISTIAE
7 1 S108-p QISTIAEsEDsQEsV
8 4 S111-p TIAEsEDsQEsVDsV
7 1 S114-p EsEDsQEsVDsVtDs
4 0 S117-p DsQEsVDsVtDsQKR
1 1 T119-p QEsVDsVtDsQKRRE
10 0 S121-p sVDsVtDsQKRREIL
10 2 S129-p QKRREILsRRPsyRk
219 63 S133-p EILsRRPsyRkILND
0 4 Y134-p ILsRRPsyRkILNDL
3 0 K136-ac sRRPsyRkILNDLss
0 2 K136-ub sRRPsyRkILNDLss
10 11 S142-p RkILNDLssDAPGVP
4 1 S143-p kILNDLssDAPGVPR
2 0 S156-p PRIEEEKsEEETSAP
0 1 S260 QIRTAPTSTIAPGVV
0 1 T261 IRTAPTSTIAPGVVM
1 1 S270-p APGVVMAssPALPTQ
3 5 S271-p PGVVMAssPALPTQP
1 0 K285-sm PAEEAARkREVRLMK
1 0 K304-sm ARECRRKkKEYVKCL
0 2 K330-ub KTLIEELkALKDLYC
1 1 S340-p KDLYCHKsD______
4095 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Biotinylated)
4276 : Phospho-CREB (Ser133) (D1G6) Rabbit mAb
9187 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9191 : Phospho-CREB (Ser133) Antibody
9196 : Phospho-CREB (Ser133) (1B6) Mouse mAb
9198 : Phospho-CREB (Ser133) (87G3) Rabbit mAb
14228 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (PE Conjugate)
  CREB iso2  
- gap
- gap
- gap
- gap
S94 QISTIAESEDSQESV
S97 TIAESEDSQESVDSV
S100 ESEDSQESVDSVTDS
S103 DSQESVDSVTDSQKR
T105 QESVDSVTDSQKRRE
S107 SVDSVTDSQKRREIL
S115 QKRREILSRRPSYRK
S119 EILSRRPSYRKILND
Y120 ILSRRPSYRKILNDL
K122 SRRPSYRKILNDLSS
K122 SRRPSYRKILNDLSS
S128 RKILNDLSSDAPGVP
S129 KILNDLSSDAPGVPR
S142 PRIEEEKSEEETSAP
S246 QIRTAPTSTIAPGVV
T247 IRTAPTSTIAPGVVM
S256 APGVVMASSPALPTQ
S257 PGVVMASSPALPTQP
K271 PAEEAARKREVRLMK
K290 ARECRRKKKEYVKCL
K316 KTLIEELKALKDLYC
S326 KDLYCHKSD______
  mouse

 
K91 QTVQSSCKDLKRLFs
K94 QSSCKDLKRLFsGtQ
S98-p KDLKRLFsGtQISTI
T100-p LKRLFsGtQISTIAE
S108-p QISTIAEsEDsQEsV
S111-p TIAEsEDsQEsVDsV
S114-p EsEDsQEsVDsVTDs
S117-p DsQEsVDsVTDsQKR
T119 QEsVDsVTDsQKRRE
S121-p sVDsVTDsQKRREIL
S129-p QKRREILsRRPsYRk
S133-p EILsRRPsYRkILND
Y134 ILsRRPsYRkILNDL
K136-ac sRRPsYRkILNDLss
K136-ub sRRPsYRkILNDLss
S142-p RkILNDLssDAPGVP
S143-p kILNDLssDAPGVPR
S156-p PRIEEEKsEEETSAP
S260-p QIRTAPTstIAPGVV
T261-p IRTAPTstIAPGVVM
S270-p APGVVMAssPALPTQ
S271-p PGVVMAssPALPTQP
K285 PAEEAARKREVRLMK
K304 ARECRRKKKEYVKCL
K330-ub KTLIEELkALKDLYC
S340-p KDLYCHKsD______
4095 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Biotinylated)
4276 : Phospho-CREB (Ser133) (D1G6) Rabbit mAb
9187 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9191 : Phospho-CREB (Ser133) Antibody
9196 : Phospho-CREB (Ser133) (1B6) Mouse mAb
9198 : Phospho-CREB (Ser133) (87G3) Rabbit mAb
14228 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (PE Conjugate)
  rat

 
K91-ac QTVQSSCkDLkRLFS
K94-ac QSSCkDLkRLFSGTQ
S98 kDLkRLFSGTQISTI
T100 LkRLFSGTQISTIAE
S108-p QISTIAEsEDsQEsV
S111-p TIAEsEDsQEsVDsV
S114-p EsEDsQEsVDsVtDs
S117-p DsQEsVDsVtDsQKR
T119-p QEsVDsVtDsQKRRE
S121-p sVDsVtDsQKRREIL
S129-p QKRREILsRRPsYRk
S133-p EILsRRPsYRkILND
Y134 ILsRRPsYRkILNDL
K136-ac sRRPsYRkILNDLss
K136 sRRPsYRKILNDLss
S142-p RkILNDLssDAPGVP
S143-p kILNDLssDAPGVPR
S156 PRIEEEKSEEETSAP
S260 QIRTAPTSTIAPGVV
T261 IRTAPTSTIAPGVVM
S270 APGVVMASSPALPTQ
S271 PGVVMASSPALPTQP
K285 PAEEAARKREVRLMK
K304 ARECRRKKKEYVKCL
K330 KTLIEELKALKDLYC
S340 KDLYCHKSD______
4095 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Biotinylated)
4276 : Phospho-CREB (Ser133) (D1G6) Rabbit mAb
9187 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
9191 : Phospho-CREB (Ser133) Antibody
9196 : Phospho-CREB (Ser133) (1B6) Mouse mAb
9198 : Phospho-CREB (Ser133) (87G3) Rabbit mAb
14228 : Phospho-CREB (Ser133) (87G3) Rabbit mAb (PE Conjugate)
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