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CREB (human)

Overview CREB a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: nucleoplasm; transcription factor complex; mitochondrion; nucleolus; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; double-stranded DNA binding; transcription cofactor activity; transcription factor activity Biological Process: lactation; axon guidance; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; positive regulation of multicellular organism growth; toll-like receptor 3 signaling pathway; signal transduction; protein amino acid phosphorylation; regulation of apoptosis; response to organic substance; synaptic transmission; positive regulation of transforming growth factor-beta3 production; transforming growth factor beta receptor signaling pathway; toll-like receptor 4 signaling pathway; epidermal growth factor receptor signaling pathway; response to drug; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; protein stabilization; MyD88-independent toll-like receptor signaling pathway; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; regulation of circadian rhythm; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; phospholipase C activation; pituitary gland development; virus-host interaction; toll-like receptor signaling pathway; innate immune response; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell size Reference #:  P16220 (UniProtKB) Alt. Names/Synonyms: active transcription factor CREB; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB-1; CREB1; Cyclic AMP-responsive element-binding protein 1; MGC9284; transactivator protein Gene Symbols: CREB1 Molecular weight: 36,688 Da Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  MAPK/Erk in Growth and Differentiation  |  Parkinson's Disease  |  Signaling Pathways Activating p38 MAPK  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CREB 1DH3 - A/C=285-339 (mouse) 1KDX - B=119-146 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 123810 612160  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, inhibited: S133‑p cell differentiation, altered: S133‑p cell growth, altered: S129‑p, S133‑p cell motility, altered: S133‑p transcription, altered: T100‑p, S111‑p, S121‑p, S129‑p, S133‑p, S271‑p activation: S133‑p inhibition: T100‑p, S111‑p, S121‑p molecular association, regulation: S108‑p, S111‑p, S114‑p, S121‑p, S129‑p, S133‑p, S271‑p phosphorylation: T100‑p, S108‑p, S111‑p, S114‑p, S117‑p, S133‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
1	0		K91	QTVQSSCKDLKRLFs
1	0		K94	QSSCKDLKRLFsGtQ
2	0		S98-p	KDLKRLFsGtQISTI
3	0		T100-p	LKRLFsGtQISTIAE
6	1		S108-p	QISTIAEsEDsQEsV
7	4		S111-p	TIAEsEDsQEsVDsV
6	1		S114-p	EsEDsQEsVDsVtDs
4	0		S117-p	DsQEsVDsVtDsQKR
1	1		T119-p	QEsVDsVtDsQKRRE
9	0		S121-p	sVDsVtDsQKRREIL
10	2		S129-p	QKRREILsRRPsyRk
209	63		S133-p	EILsRRPsyRkILND
0	4		Y134-p	ILsRRPsyRkILNDL
2	0		K136	sRRPsyRKILNDLss
0	2		K136-u	sRRPsyRkILNDLss
10	9		S142-p	RkILNDLssDAPGVP
4	1		S143-p	kILNDLssDAPGVPR
2	0		S156-p	PRIEEEKsEEETSAP
0	1		S270	APGVVMASsPALPTQ
2	2		S271-p	PGVVMASsPALPTQP
1	0		K285-s	PAEEAARkREVRLMK
1	0		K304-s	ARECRRKkKEYVKCL
0	2		K330-u	KTLIEELkALKDLYC
1	1		S340-p	KDLYCHKsD______

	CREB iso2
-	gap
-	gap
-	gap
-	gap
S94	QISTIAESEDSQESV
S97	TIAESEDSQESVDSV
S100	ESEDSQESVDSVTDS
S103	DSQESVDSVTDSQKR
T105	QESVDSVTDSQKRRE
S107	SVDSVTDSQKRREIL
S115	QKRREILSRRPSYRK
S119	EILSRRPSYRKILND
Y120	ILSRRPSYRKILNDL
K122	SRRPSYRKILNDLSS
K122	SRRPSYRKILNDLSS
S128	RKILNDLSSDAPGVP
S129	KILNDLSSDAPGVPR
S142	PRIEEEKSEEETSAP
S256	APGVVMASSPALPTQ
S257	PGVVMASSPALPTQP
K271	PAEEAARKREVRLMK
K290	ARECRRKKKEYVKCL
K316	KTLIEELKALKDLYC
S326	KDLYCHKSD______

	mouse
K91	QTVQSSCKDLKRLFs
K94	QSSCKDLKRLFsGtQ
S98-p	KDLKRLFsGtQISTI
T100-p	LKRLFsGtQISTIAE
S108-p	QISTIAEsEDsQEsV
S111-p	TIAEsEDsQEsVDsV
S114-p	EsEDsQEsVDsVTDs
S117-p	DsQEsVDsVTDsQKR
T119	QEsVDsVTDsQKRRE
S121-p	sVDsVTDsQKRREIL
S129-p	QKRREILsRRPsYRk
S133-p	EILsRRPsYRkILND
Y134	ILsRRPsYRkILNDL
K136-a	sRRPsYRkILNDLss
K136-u	sRRPsYRkILNDLss
S142-p	RkILNDLssDAPGVP
S143-p	kILNDLssDAPGVPR
S156-p	PRIEEEKsEEETSAP
S270-p	APGVVMAssPALPTQ
S271-p	PGVVMAssPALPTQP
K285	PAEEAARKREVRLMK
K304	ARECRRKKKEYVKCL
K330-u	KTLIEELkALKDLYC
S340-p	KDLYCHKsD______

	rat
K91-a	QTVQSSCkDLkRLFS
K94-a	QSSCkDLkRLFSGTQ
S98	kDLkRLFSGTQISTI
T100	LkRLFSGTQISTIAE
S108-p	QISTIAEsEDsQEsV
S111-p	TIAEsEDsQEsVDsV
S114-p	EsEDsQEsVDsVtDs
S117-p	DsQEsVDsVtDsQKR
T119-p	QEsVDsVtDsQKRRE
S121-p	sVDsVtDsQKRREIL
S129-p	QKRREILsRRPsYRk
S133-p	EILsRRPsYRkILND
Y134	ILsRRPsYRkILNDL
K136-a	sRRPsYRkILNDLss
K136	sRRPsYRKILNDLss
S142-p	RkILNDLssDAPGVP
S143-p	kILNDLssDAPGVPR
S156	PRIEEEKSEEETSAP
S270	APGVVMASSPALPTQ
S271	PGVVMASSPALPTQP
K285	PAEEAARKREVRLMK
K304	ARECRRKKKEYVKCL
K330	KTLIEELKALKDLYC
S340	KDLYCHKSD______

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