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Protein Page:
UGCGL2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UGCGL2 Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.1.-; Transferase
Cellular Component: endoplasmic reticulum lumen; ER-Golgi intermediate compartment
Molecular Function: UDP-glucose:glycoprotein glucosyltransferase activity
Biological Process: cellular protein metabolic process; protein folding; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Reference #:  Q9NYU1 (UniProtKB)
Alt. Names/Synonyms: FLJ10873; FLJ11485; hUGT2; MGC117360; MGC150689; MGC87276; UDP--Glc:glycoprotein glucosyltransferase 2; UDP-Glc:glycoprotein glucosyltransferase 2; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose ceramide glucosyltransferase-like 2; UDP-glucose glycoprotein glucosyltransferase 2; UDP-glucose:glycoprotein glucosyltransferase 2; UGCGL2; UGGG2; UGGT2; UGT2
Gene Symbols: UGGT2
Molecular weight: 174,735 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Select Structure to View Below

UGCGL2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S161-p KLLKKAAsRTRPYLF
0 3 S203-p SAFHKVLsEKAQNEE
0 1 Y213-p AQNEEILyVLRHYIQ
0 1 Y228-p KPSSRKMyLSGyGVE
0 2 Y232-p RKMyLSGyGVELAIK
0 1 K275-ac VQGFLFGkLkEIYSD
0 1 K277-ac GFLFGkLkEIYSDLR
0 1 S474-p LKPVFPGsVPsIRRN
0 2 S477-p VFPGsVPsIRRNFHN
0 1 Y623-p GPLPQALyNGEPFKH
0 1 K756-ac FDKPSGRkLLFNALK
0 1 T767 NALKHMKTSVHSRLG
0 1 S768 ALKHMKTSVHSRLGI
0 1 S771 HMKTSVHSRLGIIYN
0 1 T780 LGIIYNPTSKINEEN
0 1 S781 GIIYNPTSKINEENT
0 1 Y823-p EEIATAIySGDKIKT
0 1 Y942-p VPKRASRyDVTFLRE
0 1 S952-p TFLRENHsVIKTNPQ
0 1 T1257-p MLSVLRNtKTPVKFW
0 1 Y1289-p AKEYGFRyELVQYRW
0 2 K1343-m1 QIVRHDLkELRDFDL
  mouse

 
S152 KLLNKAVSRPRPYLF
S194 AEFHRVLSKKSKNGK
Y204 SKNGKILYVLRHYIQ
Y219 KPSSRKMYLSGYGVE
Y223 RKMYLSGYGVELAIK
K266 VQGFLFGKLKEIYSD
K268 GFLFGKLKEIYSDLK
T465 LKPVLHGTVPSVRRN
S468 VLHGTVPSVRRNFHN
Y613 GPLPQALYNGEPFDL
K745 FDVPSGRKLLFNALK
T756 NALKHMETSFHSRLG
S757 ALKHMETSFHSRLGI
S760 HMETSFHSRLGIVYN
T769 LGIVYNPTSKINEES
S770 GIVYNPTSKINEEST
Y812 EETAEAIYSGDKVQT
Y931 LAVRASRYDVTLLKE
S941 TLLKENLSVIKINPP
T1245 MLSVLRNTETPVKFW
Y1277 AKEYGFQYELVQYKW
K1331 QIVRHDLKELRDFDL
  rat

 
S162 KLLSKAASRPRPYLF
S204 AEFHRVLSKKSKNGK
Y214 SKNGKILYVLRHYIK
Y229 KPSSRKMYLSGYGVE
Y233 RKMYLSGYGVELAIK
K276 VQGFLFGKLKEIYSD
K278 GFLFGKLKEIYSDLK
- under review  
- under review  
Y618 GPLPQALYNGEHFGL
K750 FDVPSGRKLLSHALE
T761-p HALEHMEttFHsRLG
T762-p ALEHMEttFHsRLGI
S765-p HMEttFHsRLGIVYN
T774-p LGIVYNPtsKINEEN
S775-p GIVYNPtsKINEENT
Y817 EETAEAIYSGDKIKT
S936 LPVRASRSDVTLLKE
- under review  
T1252 MLSVLRNTKTPVKFW
E1285 PRGYSPEEVDFEHWY
T1343 QIVRHDLTELRDFDL
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