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UGCGL2 (human)

Overview UGCGL2 Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family. Note: This description may include information from UniProtKB. Protein type: Transferase; EC 2.4.1.- Cellular Component: endoplasmic reticulum lumen; ER-Golgi intermediate compartment Molecular Function: UDP-glucose:glycoprotein glucosyltransferase activity Biological Process: cellular protein metabolic process; protein folding; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification Reference #:  Q9NYU1 (UniProtKB) Alt. Names/Synonyms: FLJ10873; FLJ11485; hUGT2; MGC117360; MGC150689; MGC87276; UDP--Glc:glycoprotein glucosyltransferase 2; UDP-Glc:glycoprotein glucosyltransferase 2; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose ceramide glucosyltransferase-like 2; UDP-glucose glycoprotein glucosyltransferase 2; UDP-glucose:glycoprotein glucosyltransferase 2; UGCGL2; UGGG2; UGGT2; UGT2 Gene Symbols: UGGT2 Molecular weight: 174,735 Da Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states

Select Structure to View Below UGCGL2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S161-p	KLLKKAAsRTRPYLF
0	2		S203-p	SAFHKVLsEKAQNEE
0	1		Y213-p	AQNEEILyVLRHYIQ
0	2		Y228-p	KPSSRKMyLSGyGVE
0	3		Y232-p	RKMyLSGyGVELAIK
0	1		K275-a	VQGFLFGkLkEIYSD
0	1		K277-a	GFLFGkLkEIYSDLR
0	1		S474-p	LKPVFPGsVPsIRRN
0	2		S477-p	VFPGsVPsIRRNFHN
0	1		Y623-p	GPLPQALyNGEPFKH
0	1		K756-a	FDKPSGRkLLFNALK
0	1		T767	NALKHMKTSVHSRLG
0	1		S768	ALKHMKTSVHSRLGI
0	1		S771	HMKTSVHSRLGIIYN
0	1		T780	LGIIYNPTSKINEEN
0	1		S781	GIIYNPTSKINEENT
0	1		Y823-p	EEIATAIySGDKIKT
0	1		Y942-p	VPKRASRyDVTFLRE
0	1		S952-p	TFLRENHsVIKTNPQ
0	1		T1257-p	MLSVLRNtKTPVKFW
0	1		Y1289-p	AKEYGFRyELVQYRW
0	2		K1343-m1	QIVRHDLkELRDFDL

	mouse
S152	KLLNKAVSRPRPYLF
S194	AEFHRVLSKKSKNGK
Y204	SKNGKILYVLRHYIQ
Y219	KPSSRKMYLSGYGVE
Y223	RKMYLSGYGVELAIK
K266	VQGFLFGKLKEIYSD
K268	GFLFGKLKEIYSDLK
T465	LKPVLHGTVPSVRRN
S468	VLHGTVPSVRRNFHN
Y613	GPLPQALYNGEPFDL
K745	FDVPSGRKLLFNALK
T756	NALKHMETSFHSRLG
S757	ALKHMETSFHSRLGI
S760	HMETSFHSRLGIVYN
T769	LGIVYNPTSKINEES
S770	GIVYNPTSKINEEST
Y812	EETAEAIYSGDKVQT
Y931	LAVRASRYDVTLLKE
S941	TLLKENLSVIKINPP
T1245	MLSVLRNTETPVKFW
Y1277	AKEYGFQYELVQYKW
K1331	QIVRHDLKELRDFDL

	rat
S162	KLLSKAASRPRPYLF
S204	AEFHRVLSKKSKNGK
Y214	SKNGKILYVLRHYIK
Y229-p	KPSSRKMyLSGyGVE
Y233-p	RKMyLSGyGVELAIK
K276	VQGFLFGKLKEIYSD
K278	GFLFGKLKEIYSDLK
-	under review
-	under review
Y618	GPLPQALYNGEHFGL
K750	FDVPSGRKLLSHALE
T761-p	HALEHMEttFHsRLG
T762-p	ALEHMEttFHsRLGI
S765-p	HMEttFHsRLGIVYN
T774-p	LGIVYNPtsKINEEN
S775-p	GIVYNPtsKINEENT
Y817	EETAEAIYSGDKIKT
S936	LPVRASRSDVTLLKE
-	under review
T1252	MLSVLRNTKTPVKFW
E1285	PRGYSPEEVDFEHWY
T1343	QIVRHDLTELRDFDL

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