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Protein Page:
Bcl-11B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Bcl-11B Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Nuclear receptor co-regulator
Cellular Component: nucleus
Molecular Function: protein binding; metal ion binding
Biological Process: positive T cell selection; post-embryonic camera-type eye development; regulation of lipid metabolic process; thymus development; transcription, DNA-dependent; regulation of neuron differentiation; T cell differentiation in the thymus; alpha-beta T cell differentiation; odontogenesis of dentine-containing teeth; negative regulation of cell proliferation; striatal medium spiny neuron differentiation; T cell receptor V(D)J recombination; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis
Reference #:  Q9C0K0 (UniProtKB)
Alt. Names/Synonyms: B-cell CLL/lymphoma 11B; B-cell CLL/lymphoma 11B (zinc finger protein); B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion protein; B-cell lymphoma/leukaemia 11B; B-cell lymphoma/leukemia 11B; BC11B; BCL-11B; BCL11B; BCL11B/TRDC fusion; COUP-TF-interacting protein 2; CTIP-2; CTIP2; hRit1; hRIT1-alpha; Radiation-induced tumor suppressor gene 1 protein; RIT1; zinc finger protein hRit1 alpha
Gene Symbols: BCL11B
Molecular weight: 95,519 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcl-11B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S13-p QGNPQHLsQRELITP
0 1 S84-p KRKQCGGsLGACyDK
0 5 Y89-p GGsLGACyDKALDKD
0 2 D96 yDKALDKDsPPPSSR
0 7 S97-p DKALDKDsPPPSSRS
0 2 S110 RSELRKVSEPVEIGI
0 2 T120-p VEIGIQVtPDEDDHL
0 5 S129-p DEDDHLLsPtKGICP
0 1 T131-p DDHLLsPtKGICPKQ
0 1 A152 CRPAQLPAVAPIAAS
0 2 S169-p PHSSVITsPLRALGA
0 11 S256-p YLEPGPAsssLtPRL
0 4 S257-p LEPGPAsssLtPRLT
0 11 S258-p EPGPAsssLtPRLTI
0 52 T260-p GPAsssLtPRLTIPP
0 3 S277-p GPEAVAQsPLMNFLG
0 1 S286-p LMNFLGDsNPFNLLR
0 1 R293 sNPFNLLRMTGPILR
0 42 T313-p GEGRLPGtPPLFsPP
0 30 S318-p PGtPPLFsPPPRHHL
0 1 R322 PLFsPPPRHHLDPHR
0 29 S358-p LNPMAIDsPAMDFsR
0 1 S364-p DsPAMDFsRRLRELA
0 3 S374-p LRELAGNsstPPPVs
0 4 S375-p RELAGNsstPPPVsP
0 42 T376-p ELAGNsstPPPVsPG
0 56 S381-p sstPPPVsPGRGNPM
0 7 S398-p LLNPFQPsPKsPFLs
0 15 S401-p PFQPsPKsPFLstPP
0 7 S405-p sPKsPFLstPPLPPM
0 11 T406-p PKsPFLstPPLPPMP
0 31 T417-p PPMPPGGtPPPQPPA
0 13 S465-p QLCDHACsQASKLKR
0 1 S483-p THMHKAGsLAGRsDD
0 2 S488-p AGsLAGRsDDGLsAA
0 1 S493-p GRsDDGLsAAssPEP
0 7 S496-p DDGLsAAssPEPGtS
0 10 S497-p DGLsAAssPEPGtSE
0 1 T502-p AssPEPGtSELAGEG
0 2 S522-p GDFRHHEsDPSLGHE
0 2 S550-p ELLLENEsRPESSFs
0 1 S555 NEsRPESSFsMDsEL
0 2 S557-p sRPESSFsMDsELSR
0 2 S560-p ESSFsMDsELSRNRE
0 4 K591-ub AKALADEkALVLGKV
0 11 T662-p GGGFAPGtEPFPGLF
0 4 K672-ub FPGLFPRkPAPLPsP
0 3 S678-p RkPAPLPsPGLNSAA
0 5 K686-ub PGLNSAAkRIkVEKD
0 1 K689-ub NSAAkRIkVEKDLEL
0 1 K689 NSAAkRIKVEKDLEL
0 1 Y708-p LIPSENVySQWLVGY
0 2 K723-ub AASRHFMkDPFLGFt
0 1 T730-p kDPFLGFtDARQsPF
0 3 S735-p GFtDARQsPFAtSsE
0 1 T739-p ARQsPFAtSsEHSSE
0 1 S741-p QsPFAtSsEHSSENG
0 1 S744 FAtSsEHSSENGSLR
0 8 S753-p ENGSLRFstPPGDLL
0 19 T754-p NGSLRFstPPGDLLD
0 1 S765-p DLLDGGLsGRsGTAs
0 1 S768-p DGGLsGRsGTAsGGs
0 25 S772-p sGRsGTAsGGstPHL
0 8 S775-p sGTAsGGstPHLGGP
0 12 T776-p GTAsGGstPHLGGPG
0 9 S788-p GPGPGRPssKEGRRS
0 3 S789-p PGPGRPssKEGRRSD
0 1 T819-p TVHRRSHtGERPYKC
0 1 K851-ac KTHGQIGkEVYRCDI
0 1 K874 STLEKHMKKWHGEHL
0 1 K887 HLLTNDVKIEQAERS
0 1 K887 HLLTNDVKIEQAERS
  mouse

 
S13 QGNPQHLSQRELITP
- gap
Y88 CGGLGPCYDKVLDKs
S95-p YDKVLDKssPPPSSR
S96-p DKVLDKssPPPSSRS
S109-p RSELRRVsEPVEIGI
T119-p VEIGIQVtPDEDDHL
S128-p DEDDHLLsPtKGICP
T130-p DDHLLsPtKGICPKQ
S151-p CRPAQLPsMAPIAAS
S169-p PPTSVITsPLRALGV
S256 YLEPGPASTSLtPRL
T257 LEPGPASTSLtPRLT
S258 EPGPASTSLtPRLTI
T260-p GPASTSLtPRLTIPP
S277-p GPETVAQsPLMNFLG
S286 LMNFLGDSNPFNLLr
R293-m1 SNPFNLLrMTGPILR
T313-p GEGRLPGtPPLFsPP
S318-p PGtPPLFsPPPrHHL
R322-m2 PLFsPPPrHHLDPHR
S358 LNPMAIDSPAMDFSR
S364 DSPAMDFSRRLRELA
S374-p LRELAGNsstPPPVs
S375-p RELAGNsstPPPVsP
T376-p ELAGNsstPPPVsPG
S381-p sstPPPVsPGRGNPM
S398-p LLNPFQPsPKsPFLs
S401-p PFQPsPKsPFLstPP
S405-p sPKsPFLstPPLPPM
T406-p PKsPFLstPPLPPMP
T416-p LPPMPAGtPPPQPPA
S464 QLCDHACSQASKLKR
S482 THMHKAGSLAGRSDD
S487 AGSLAGRSDDGLSAA
S492 GRSDDGLSAAssPEP
S495-p DDGLSAAssPEPGTS
S496-p DGLSAAssPEPGTSE
T501 AssPEPGTSELPGDL
S520 GDFRHHESDPSLGPE
S547 ELLLENESRPESsFs
S552-p NESRPESsFsMDsEL
S554-p SRPESsFsMDsELGR
S557-p ESsFsMDsELGRGRE
K587 AAALADEKALALGKV
A648 GGAFAPGAEPFPALF
K658 FPALFPRKPAPLPsP
S664-p RKPAPLPsPGLGGPA
K676 GPALHAAKRIkVEKD
K679 LHAAKRIKVEKDLEL
K679-sm LHAAKRIkVEKDLEL
Y698 LIPSENVYSQWLVGY
K713 AASRHFMKDPFLGFT
T720 KDPFLGFTDARQsPF
S725-p GFTDARQsPFATSsE
T729 ARQsPFATSsEHsSE
S731-p QsPFATSsEHsSENG
S734-p FATSsEHsSENGSLR
S743-p ENGSLRFstPPGDLL
T744-p NGSLRFstPPGDLLD
S755 DLLDGGLSGRSGTAs
S758 DGGLSGRSGTAsGGs
S762-p SGRSGTAsGGstPHL
S765-p SGTAsGGstPHLGGP
T766-p GTAsGGstPHLGGPG
S778-p GPGPGRPssKEGRRS
S779-p PGPGRPssKEGRRSD
T809 TVHRRSHTGERPYKC
K841 KTHGQIGKEVYRCDI
K864-ac STLEKHMkKWHGEHL
K877-ac HLLTNDVkIEQAERS
K877-sm HLLTNDVkIEQAERS
  rat

 
- gap
- gap
Y42 CGGLGSCYDKVLDKG
G49 YDKVLDKGSPPPSSR
S50 DKVLDKGSPPPSSRS
S63 RSELRRVSEPVEIGI
T73 VEIGIQVTPDEDDHL
S82 DEDDHLLSPTKGICP
T84 DDHLLSPTKGICPKQ
- gap
- gap
S138 YLEPGPASTSLTPRL
T139 LEPGPASTSLTPRLT
S140 EPGPASTSLTPRLTI
T142 GPASTSLTPRLTIPP
S159 GPEAVAQSPLMNFLG
S168 LMNFLGDSNPFNLLR
R175 SNPFNLLRMTGPILR
T195 GEGRLPGTPPLFSPP
S200 PGTPPLFSPPPRHHL
R204 PLFSPPPRHHLDPHR
S240 LNPMAIDSPAMDFSR
S246 DSPAMDFSRRLRELA
S256-p LRELAGNsStPPPVs
S257 RELAGNsStPPPVsP
T258-p ELAGNsStPPPVsPG
S263-p sStPPPVsPGRGNPM
S280 LLNPFQPSPKSPFLS
S283 PFQPSPKSPFLSTPP
S287 SPKSPFLSTPPLPPM
T288 PKSPFLSTPPLPPMP
T298 LPPMPTGTPPPQPPA
S346 QLCDHACSQASKLKR
S364 THMHKAGSLAGRSDD
S369 AGSLAGRSDDGLSAA
S374 GRSDDGLSAASSPEP
S377 DDGLSAASSPEPGTS
S378 DGLSAASSPEPGTSE
T383 ASSPEPGTSELPGDL
S402 GDFRHHESDPSLGPE
S429 ELLLENESRPESSFS
S434 NESRPESSFSMDSEL
S436 SRPESSFSMDSELGR
S439 ESSFSMDSELGRGRE
K469 AAALADEKALALGKV
A530 GGAFAPGAEPFPALF
K540 FPALFPRKPAPLPSP
S546 RKPAPLPSPGLGGPA
K558 GPALHAAKRIKVEKD
K561 LHAAKRIKVEKDLEL
K561 LHAAKRIKVEKDLEL
Y580-p LIPSENVySQWLVGY
K595 AASRHFMKDPFLGFT
T602 KDPFLGFTDARQSPF
S607 GFTDARQSPFATSSE
T611 ARQSPFATSSEHSSE
S613 QSPFATSSEHSSENG
S616 FATSSEHSSENGSLR
S625-p ENGSLRFstPPGDLL
T626-p NGSLRFstPPGDLLD
S637 DLLDGGLSGRSGTAs
S640 DGGLSGRSGTAsGGS
S644-p SGRSGTAsGGSTPHL
S647 SGTAsGGSTPHLGGP
T648 GTAsGGSTPHLGGPG
S660 GPGPGRPSSKEGRRS
S661 PGPGRPSSKEGRRSD
T691 TVHRRSHTGERPYKC
K723 KTHGQIGKEVYRCDI
K746 STLEKHMKKWHGEHL
K759 HLLTNDVKIEQAERS
K759 HLLTNDVKIEQAERS
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