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Bcl-11B (human)

Overview Bcl-11B Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Nuclear receptor co-regulator; C2H2-type zinc finger protein Cellular Component: nucleus Molecular Function: zinc ion binding Biological Process: skin development; positive T cell selection; post-embryonic camera-type eye development; regulation of lipid metabolic process; thymus development; T cell differentiation in the thymus; alpha-beta T cell differentiation; odontogenesis of dentine-containing teeth; negative regulation of cell proliferation; axonogenesis; striatal medium spiny neuron differentiation; T cell receptor V(D)J recombination; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis Reference #:  Q9C0K0 (UniProtKB) Alt. Names/Synonyms: B-cell CLL/lymphoma 11B; B-cell CLL/lymphoma 11B (zinc finger protein); B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion protein; B-cell lymphoma/leukaemia 11B; B-cell lymphoma/leukemia 11B; BC11B; BCL-11B; BCL11B; BCL11B/TRDC fusion; COUP-TF-interacting protein 2; CTIP-2; CTIP2; hRit1; hRIT1-alpha; Radiation-induced tumor suppressor gene 1 protein; RIT1; zinc finger protein hRit1 alpha Gene Symbols: BCL11B Molecular weight: 95,519 Da Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Bcl-11B

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S13-p	QGNPQHLsQRELITP
0	1		S84-p	KRKQCGGsLGACyDK
0	5		Y89-p	GGsLGACyDKALDKD
0	1		D96	yDKALDKDsPPPSSR
0	5		S97-p	DKALDKDsPPPSSRS
0	1		S110	RSELRKVSEPVEIGI
0	2		T120-p	VEIGIQVtPDEDDHL
0	3		S129-p	DEDDHLLsPtKGICP
0	1		T131-p	DDHLLsPtKGICPKQ
0	1		A152	CRPAQLPAVAPIAAS
0	1		S169-p	PHSSVITsPLRALGA
0	11		S256-p	YLEPGPAsssLtPRL
0	4		S257-p	LEPGPAsssLtPRLT
0	11		S258-p	EPGPAsssLtPRLTI
0	51		T260-p	GPAsssLtPRLTIPP
0	2		S277-p	GPEAVAQsPLMNFLG
0	1		S286-p	LMNFLGDsNPFNLLR
0	38		T313-p	GEGRLPGtPPLFsPP
0	28		S318-p	PGtPPLFsPPPRHHL
0	30		S358-p	LNPMAIDsPAMDFsR
0	1		S364-p	DsPAMDFsRRLRELA
0	3		S374-p	LRELAGNsstPPPVs
0	5		S375-p	RELAGNsstPPPVsP
0	42		T376-p	ELAGNsstPPPVsPG
0	51		S381-p	sstPPPVsPGRGNPM
0	6		S398-p	LLNPFQPsPKsPFLs
0	14		S401-p	PFQPsPKsPFLstPP
0	7		S405-p	sPKsPFLstPPLPPM
0	10		T406-p	PKsPFLstPPLPPMP
0	30		T417-p	PPMPPGGtPPPQPPA
0	13		S465-p	QLCDHACsQASKLKR
0	1		S483-p	THMHKAGsLAGRsDD
0	2		S488-p	AGsLAGRsDDGLsAA
0	1		S493-p	GRsDDGLsAAssPEP
0	7		S496-p	DDGLsAAssPEPGtS
0	9		S497-p	DGLsAAssPEPGtSE
0	1		T502-p	AssPEPGtSELAGEG
0	2		S522-p	GDFRHHEsDPSLGHE
0	2		S550-p	ELLLENEsRPESSFs
0	1		S555	NEsRPESSFsMDsEL
0	2		S557-p	sRPESSFsMDsELSR
0	2		S560-p	ESSFsMDsELSRNRE
0	4		K591-u	AKALADEkALVLGKV
0	11		T662-p	GGGFAPGtEPFPGLF
0	4		K672-u	FPGLFPRkPAPLPsP
0	2		S678-p	RkPAPLPsPGLNSAA
0	5		K686-u	PGLNSAAkRIkVEKD
0	1		K689-u	NSAAkRIkVEKDLEL
1	0		K689	NSAAkRIKVEKDLEL
0	3		Y708-p	LIPSENVySQWLVGY
0	2		K723-u	AASRHFMkDPFLGFT
0	3		S735-p	GFTDARQsPFAtSSE
0	1		T739-p	ARQsPFAtSSEHSSE
0	7		S753-p	ENGSLRFstPPGDLL
0	18		T754-p	NGSLRFstPPGDLLD
0	1		S765-p	DLLDGGLsGRsGTAs
0	1		S768-p	DGGLsGRsGTAsGGs
0	23		S772-p	sGRsGTAsGGstPHL
0	7		S775-p	sGTAsGGstPHLGGP
0	14		T776-p	GTAsGGstPHLGGPG
0	8		S788-p	GPGPGRPssKEGRRS
0	2		S789-p	PGPGRPssKEGRRSD
0	1		K851-a	KTHGQIGkEVYRCDI
0	1		K874	STLEKHMKKWHGEHL
0	1		K887	HLLTNDVKIEQAERS
1	0		K887	HLLTNDVKIEQAERS

	mouse
S13	QGNPQHLSQRELITP
-	gap
Y88	CGGLGPCYDKVLDKs
S95-p	YDKVLDKssPPPSSR
S96-p	DKVLDKssPPPSSRS
S109-p	RSELRRVsEPVEIGI
T119-p	VEIGIQVtPDEDDHL
S128-p	DEDDHLLsPtKGICP
T130-p	DDHLLsPtKGICPKQ
S151-p	CRPAQLPsMAPIAAS
S169	PPTSVITSPLRALGV
S256	YLEPGPASTSLtPRL
T257	LEPGPASTSLtPRLT
S258	EPGPASTSLtPRLTI
T260-p	GPASTSLtPRLTIPP
S277	GPETVAQSPLMNFLG
S286	LMNFLGDSNPFNLLR
T313-p	GEGRLPGtPPLFsPP
S318-p	PGtPPLFsPPPRHHL
S358	LNPMAIDSPAMDFSR
S364	DSPAMDFSRRLRELA
S374-p	LRELAGNsstPPPVs
S375-p	RELAGNsstPPPVsP
T376-p	ELAGNsstPPPVsPG
S381-p	sstPPPVsPGRGNPM
S398-p	LLNPFQPsPKsPFLs
S401-p	PFQPsPKsPFLstPP
S405-p	sPKsPFLstPPLPPM
T406-p	PKsPFLstPPLPPMP
T416-p	LPPMPAGtPPPQPPA
S464	QLCDHACSQASKLKR
S482	THMHKAGSLAGRSDD
S487	AGSLAGRSDDGLSAA
S492	GRSDDGLSAAssPEP
S495-p	DDGLSAAssPEPGTS
S496-p	DGLSAAssPEPGTSE
T501	AssPEPGTSELPGDL
S520	GDFRHHESDPSLGPE
S547	ELLLENESRPESsFs
S552-p	NESRPESsFsMDsEL
S554-p	SRPESsFsMDsELGR
S557-p	ESsFsMDsELGRGRE
K587	AAALADEKALALGKV
A648	GGAFAPGAEPFPALF
K658	FPALFPRKPAPLPSP
S664	RKPAPLPSPGLGGPA
K676	GPALHAAKRIkVEKD
K679	LHAAKRIKVEKDLEL
K679-s	LHAAKRIkVEKDLEL
Y698	LIPSENVYSQWLVGY
K713	AASRHFMKDPFLGFT
S725-p	GFTDARQsPFATSSE
T729	ARQsPFATSSEHSSE
S743-p	ENGSLRFstPPGDLL
T744-p	NGSLRFstPPGDLLD
S755	DLLDGGLSGRSGTAs
S758	DGGLSGRSGTAsGGs
S762-p	SGRSGTAsGGstPHL
S765-p	SGTAsGGstPHLGGP
T766-p	GTAsGGstPHLGGPG
S778-p	GPGPGRPsSKEGRRS
S779	PGPGRPsSKEGRRSD
K841	KTHGQIGKEVYRCDI
K864-a	STLEKHMkKWHGEHL
K877-a	HLLTNDVkIEQAERS
K877-s	HLLTNDVkIEQAERS

	rat
-	gap
-	gap
Y42	CGGLGSCYDKVLDKG
G49	YDKVLDKGSPPPSSR
S50	DKVLDKGSPPPSSRS
S63	RSELRRVSEPVEIGI
T73	VEIGIQVTPDEDDHL
S82	DEDDHLLSPTKGICP
T84	DDHLLSPTKGICPKQ
-	gap
-	gap
S138	YLEPGPASTSLTPRL
T139	LEPGPASTSLTPRLT
S140	EPGPASTSLTPRLTI
T142	GPASTSLTPRLTIPP
S159	GPEAVAQSPLMNFLG
S168	LMNFLGDSNPFNLLR
T195	GEGRLPGTPPLFSPP
S200	PGTPPLFSPPPRHHL
S240	LNPMAIDSPAMDFSR
S246	DSPAMDFSRRLRELA
S256	LRELAGNSSTPPPVS
S257	RELAGNSSTPPPVSP
T258	ELAGNSSTPPPVSPG
S263	SSTPPPVSPGRGNPM
S280	LLNPFQPSPKSPFLS
S283	PFQPSPKSPFLSTPP
S287	SPKSPFLSTPPLPPM
T288	PKSPFLSTPPLPPMP
T298	LPPMPTGTPPPQPPA
S346	QLCDHACSQASKLKR
S364	THMHKAGSLAGRSDD
S369	AGSLAGRSDDGLSAA
S374	GRSDDGLSAASSPEP
S377	DDGLSAASSPEPGTS
S378	DGLSAASSPEPGTSE
T383	ASSPEPGTSELPGDL
S402	GDFRHHESDPSLGPE
S429	ELLLENESRPESSFS
S434	NESRPESSFSMDSEL
S436	SRPESSFSMDSELGR
S439	ESSFSMDSELGRGRE
K469	AAALADEKALALGKV
A530	GGAFAPGAEPFPALF
K540	FPALFPRKPAPLPSP
S546	RKPAPLPSPGLGGPA
K558	GPALHAAKRIKVEKD
K561	LHAAKRIKVEKDLEL
K561	LHAAKRIKVEKDLEL
Y580-p	LIPSENVySQWLVGY
K595	AASRHFMKDPFLGFT
S607	GFTDARQSPFATSSE
T611	ARQSPFATSSEHSSE
S625	ENGSLRFSTPPGDLL
T626	NGSLRFSTPPGDLLD
S637	DLLDGGLSGRSGTAS
S640	DGGLSGRSGTASGGS
S644	SGRSGTASGGSTPHL
S647	SGTASGGSTPHLGGP
T648	GTASGGSTPHLGGPG
S660	GPGPGRPSSKEGRRS
S661	PGPGRPSSKEGRRSD
K723	KTHGQIGKEVYRCDI
K746	STLEKHMKKWHGEHL
K759	HLLTNDVKIEQAERS
K759	HLLTNDVKIEQAERS

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