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beclin 1 (human)

Overview beclin 1 an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. Note: This description may include information from UniProtKB. Protein type: Autophagy; Adaptor/scaffold; Membrane protein, peripheral Cellular Component: Golgi apparatus; protein complex; membrane; cytoplasmic membrane-bound vesicle; trans-Golgi network Molecular Function: protein binding Biological Process: negative regulation of cell proliferation; lysosome organization and biogenesis; virus-host interaction; beta-amyloid metabolic process; neuron development; cytokinesis; cellular defense response; cell cycle; defense response to virus; positive regulation of macroautophagy; autophagic vacuole formation; negative regulation of apoptosis Reference #:  Q14457 (UniProtKB) Alt. Names/Synonyms: ATG6; ATG6 autophagy related 6 homolog; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; beclin1; BECN1; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS30 Gene Symbols: BECN1 Molecular weight: 51,896 Da Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states CST Pathways:  Autophagy Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below beclin 1 2P1L - B/D/F/H=107-135 (human) 2PON - A=106-128 (human) 3DVU - D/C=105-130 (human) 4DDP - A=241-450 (human) 3BL2 - D/C=106-124 (mouse) 3Q8T - A/B=174-264 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2P1L 2PON 3DVU 4DDP  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
activation: T119‑p molecular association, regulation: T119‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S30-p	QPLKLDTsFkILDRV
0	1		K32-u	LKLDTsFkILDRVtI
0	1		T38-p	FkILDRVtIQELTAP
0	1		T57-p	AQAKPGEtQEEETNs
0	2		S64-p	tQEEETNsGEEPFIE
0	11		S90-p	IPPARMMstEsANsF
0	6		T91-p	PPARMMstEsANsFT
0	2		S93-p	ARMMstEsANsFTLI
0	2		S96-p	MstEsANsFTLIGEA
0	1		S104	FTLIGEASDGGTMEN
1	0		K117-u	ENLSRRLkVtGDLFD
2	0		T119-p	LSRRLkVtGDLFDIM
0	1		S177	EQMNEDDSEQLQMEL
0	1		K206-a	EDVEKNRkIVAENLE
1	0		S234-p	AQYQREYsEFKRQQL
1	0		S295-p	FRLGRLPsVPVEWNE
0	1		K402-u	RMDVEKGkIEDTGGS
0	1		K430	EQWTKALKFMLTNLK

	mouse
S29	QPLKLDTSFKILDRV
K31	LKLDTSFKILDRVTI
T37	FKILDRVTIQELTAP
T56	AQAKPGETQEEEANS
S63	TQEEEANSGEEPFIE
S88-p	IPPARMMsTESANSF
T89	PPARMMsTESANSFT
S91	ARMMsTESANSFTLI
S94	MsTESANSFTLIGEA
S102-p	FTLIGEAsDGGTMEN
K115	ENLSRRLKVTGDLFD
T117	LSRRLKVTGDLFDIM
S175-p	EQMNEDDsEQLQREL
K204	EDVEKNRKVVAENLE
S232	AQYQREYSEFKRQQL
S293	FRLGRLPSVPVEWNE
K400	RMDVEKGKIEDTGGS
K428-u	EQWTKALkFMLTNLK

	rat
S29	QPLKLDTSFKILDRV
K31	LKLDTSFKILDRVTI
T37	FKILDRVTIQELTAP
S56	AQAKPGESQEEEANS
S63	SQEEEANSGEEPFIE
S88	IPPARMMSTESANSF
T89	PPARMMSTESANSFT
S91	ARMMSTESANSFTLI
S94	MSTESANSFTLIGEA
S102	FTLIGEASDGGTMEN
K115	ENLSRRLKVTGDLFD
T117	LSRRLKVTGDLFDIM
S175	EQMNEGDSEQLQREL
K204	EDVEKNRKVVAENLE
S232-p	AQYQREYsEFKRQQL
S293-p	FRLGRLPsAPVEWNE
K400	RMDVEKGKIEDTGGS
K428	EQWTKALKFMLTNLK

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