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Protein Page:
beclin 1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
beclin 1 an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, peripheral; Adaptor/scaffold; Autophagy
Cellular Component: protein complex; membrane; cytoplasmic membrane-bound vesicle; dendrite; trans-Golgi network; nucleus
Molecular Function: protein binding
Biological Process: response to drug; viral reproduction; cytokinesis; negative regulation of cell proliferation; response to vitamin E; lysosome organization and biogenesis; beta-amyloid metabolic process; response to hypoxia; neuron development; cellular defense response; defense response to virus; positive regulation of macroautophagy; negative regulation of apoptosis; autophagic vacuole formation
Reference #:  Q14457 (UniProtKB)
Alt. Names/Synonyms: ATG6; ATG6 autophagy related 6 homolog; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; beclin1; BECN1; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS30
Gene Symbols: BECN1
Molecular weight: 51,896 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

beclin 1

Protein Structure Not Found.


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Sites Implicated In
activity, induced: T119‑p
molecular association, regulation: T119‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S15 NNSTMQVSFVCQRCS
0 2 S30-p QPLKLDTsFkILDRV
0 1 K32-ub LKLDTsFkILDRVtI
0 1 T38-p FkILDRVtIQELTAP
0 1 T57-p AQAKPGEtQEEETNs
0 2 S64-p tQEEETNsGEEPFIE
1 11 S90-p IPPARMMstEsANsF
0 6 T91-p PPARMMstEsANsFT
2 2 S93-p ARMMstEsANsFTLI
1 2 S96-p MstEsANsFTLIGEA
0 1 S104 FTLIGEASDGGtMEN
1 0 T108-p GEASDGGtMENLSRR
1 0 K117-ub ENLSRRLkVtGDLFD
2 0 T119-p LSRRLkVtGDLFDIM
0 1 S177 EQMNEDDSEQLQMEL
0 1 K206-ac EDVEKNRkIVAENLE
1 0 Y229-p LDQEEAQyQREysEF
1 0 Y233-p EAQyQREysEFKRQQ
1 0 S234-p AQyQREysEFKRQQL
1 0 S295-p FRLGRLPsVPVEWNE
1 0 Y352-p KSKELPLyCSGGLRF
0 1 K402-ub RMDVEKGkIEDTGGS
0 1 K430 EQWTKALKFMLTNLK
13825 : Phospho-Beclin-1 (Ser15) Antibody
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
  mouse

 
S14-p SSSTMQVsFVCQRCS
S29 QPLKLDTSFKILDRV
K31 LKLDTSFKILDRVTI
T37 FKILDRVTIQELTAP
T56 AQAKPGETQEEEANS
S63 TQEEEANSGEEPFIE
S88-p IPPARMMsTESANSF
T89 PPARMMsTESANSFT
S91 ARMMsTESANSFTLI
S94 MsTESANSFTLIGEA
S102-p FTLIGEAsDGGTMEN
T106 GEAsDGGTMENLSRR
K115 ENLSRRLKVTGDLFD
T117 LSRRLKVTGDLFDIM
S175-p EQMNEDDsEQLQREL
K204 EDVEKNRKVVAENLE
Y227 LDQEEAQYQREYSEF
Y231 EAQYQREYSEFKRQQ
S232 AQYQREYSEFKRQQL
S293 FRLGRLPSVPVEWNE
Y350 KSKELPLYCSGGLRF
K400 RMDVEKGKIEDTGGS
K428-ub EQWTKALkFMLTNLK
13825 : Phospho-Beclin-1 (Ser15) Antibody
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
  rat

 
S14 SSSTMQVSFVCQRCS
S29 QPLKLDTSFKILDRV
K31 LKLDTSFKILDRVTI
T37 FKILDRVTIQELTAP
S56 AQAKPGESQEEEANS
S63 SQEEEANSGEEPFIE
S88 IPPARMMSTESANSF
T89 PPARMMSTESANSFT
S91 ARMMSTESANSFTLI
S94 MSTESANSFTLIGEA
S102 FTLIGEASDGGTMEN
T106 GEASDGGTMENLSRR
K115 ENLSRRLKVTGDLFD
T117 LSRRLKVTGDLFDIM
S175 EQMNEGDSEQLQREL
K204 EDVEKNRKVVAENLE
Y227 LDQEEAQYQREYsEF
Y231 EAQYQREYsEFKRQQ
S232-p AQYQREYsEFKRQQL
S293-p FRLGRLPsAPVEWNE
Y350 KSKELPLYCSGGLRF
K400 RMDVEKGKIEDTGGS
K428 EQWTKALKFMLTNLK
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
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