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Protein Page:
Claudin-14 (human)

Overview
Claudin-14 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29). DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the claudin family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: tight junction; endoplasmic reticulum; plasma membrane; integral to membrane
Molecular Function: identical protein binding; structural molecule activity
Biological Process: intercellular junction assembly and maintenance; protein complex assembly; calcium-independent cell-cell adhesion
Reference #:  O95500 (UniProtKB)
Alt. Names/Synonyms: claudin 14; Claudin-14; claudin14; CLD14; CLDN14; DFNB29
Gene Symbols: CLDN14
Molecular weight: 25,699 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
Select Structure to View Below

Claudin-14

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y194-p DEAPYRPyQAPPRAT
0 3 Y211-p TANTAPAyQPPAAyK
0 2 Y217-p AyQPPAAyKDNRAPS
0 2 S224 yKDNRAPSVTSATHS
0 1 S227 NRAPSVTSATHSGyR
0 2 S231 SVTSATHSGyRLNDY
0 1 Y233-p TSATHSGyRLNDYV_
  mouse

 
Y194 DEAPYRPYPPQSRAG
Y211 TTATAPAYRPPAAYK
Y217 AYRPPAAYKDNRAPs
S224-p YKDNRAPsVTsAAHs
S227-p NRAPsVTsAAHsGYR
S231-p sVTsAAHsGYRLNDY
Y233 TsAAHsGYRLNDYV_
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