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cofilin 1 (mouse)

Overview cofilin 1 a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein Cellular Component: cortical actin cytoskeleton; cytoskeleton; cell projection; membrane; lamellipodium; leading edge; cytoplasm; plasma membrane; intracellular; nucleus Molecular Function: actin binding Biological Process: positive regulation of actin filament depolymerization; cytokinesis; actin filament organization; cytoskeleton organization and biogenesis; negative regulation of cell size; response to amino acid stimulus; protein amino acid phosphorylation; neural fold formation; cell projection organization and biogenesis; protein import into nucleus; establishment of cell polarity; regulation of cell morphogenesis; cell motility; neural crest cell migration Reference #:  P18760 (UniProtKB) Alt. Names/Synonyms: AA959946; Cfl1; Cof; COF1; cofilin 1, non-muscle; Cofilin, non-muscle isoform; Cofilin-1 Gene Symbols: Cfl1 Molecular weight: 18,560 Da Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below cofilin 1 1Q8G - A=1-166 (human) 1Q8X - A=1-166 (human) 3J0S - S/O/W/T/X/N/P/V/Q/M/R/U=1-166 (human)

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	Sites Implicated In
cytoskeletal reorganization: S3‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
49	29		S3-p	_____MAsGVAVsDG
0	2		S8-p	MAsGVAVsDGVIKVF
0	4		K13	AVsDGVIKVFNDMkV
0	2		K13	AVsDGVIKVFNDMkV
0	4		K19	IKVFNDMKVRKSstP
0	12		K19-u	IKVFNDMkVRKSstP
0	5		K22	FNDMkVRKSstPEEV
1	2		S23	NDMkVRKSstPEEVK
1	12		S24-p	DMkVRKSstPEEVKk
0	15		T25-p	MkVRKSstPEEVKkR
0	3		K30	SstPEEVKkRkKAVL
0	1		K30	SstPEEVKkRkKAVL
0	1		K31	stPEEVKKRkKAVLF
0	1		K31-u	stPEEVKkRkKAVLF
0	3		K33-a	PEEVKkRkKAVLFCL
0	5		S41-p	KAVLFCLsEDkkNII
0	44		K44-a	LFCLsEDkkNIILEE
0	11		K44-u	LFCLsEDkkNIILEE
0	4		K45	FCLsEDkKNIILEEG
0	7		K45-u	FCLsEDkkNIILEEG
0	6		K53	NIILEEGKEILVGDV
0	1		T63	LVGDVGQTVDDPytT
1	428		Y68-p	GQTVDDPytTFVkML
0	1		T69-p	QTVDDPytTFVkMLP
0	9		T70	TVDDPytTFVkMLPD
0	10		K73-u	DPytTFVkMLPDkDC
0	1		K73	DPytTFVKMLPDkDC
0	2		K78-u	FVkMLPDkDCRYALy
0	2		K78	FVkMLPDKDCRYALy
0	46		Y82	LPDkDCRYALyDAty
0	287		Y85-p	kDCRYALyDAtyEtk
0	55		T88-p	RYALyDAtyEtkESk
0	545		Y89-p	YALyDAtyEtkESkk
0	7		T91-p	LyDAtyEtkESkkED
0	99		K92-u	yDAtyEtkESkkEDL
0	8		K95-u	tyEtkESkkEDLVFI
0	8		K96-a	yEtkESkkEDLVFIF
0	1		K96	yEtkESkKEDLVFIF
0	73		K112-u	APENAPLkSkMIyAS
0	57		K114-u	ENAPLkSkMIyASSk
0	188		Y117-p	PLkSkMIyASSkDAI
0	3		K121	kMIyASSKDAIKKKL
0	5		K121-u	kMIyASSkDAIKKKL
0	1		K125	ASSkDAIKKKLTGIK
1	8		K126	SSkDAIKKKLTGIKH
1	8		K127	SkDAIKKKLTGIKHE
1	17		K132	KKKLTGIKHELQANC
0	9		K132	KKKLTGIKHELQANC
0	1939		Y140-p	HELQANCyEEVkDRC
0	15		K144-a	ANCyEEVkDRCtLAE
0	100		K144-u	ANCyEEVkDRCtLAE
0	1		T148-p	EEVkDRCtLAEKLGG
0	10		S156-p	LAEKLGGsAVISLEG
0	26		K164-u	AVISLEGkPL_____

	human
S3-p	_____MAsGVAVsDG
S8-p	MAsGVAVsDGVIkVF
K13-a	AVsDGVIkVFNDMkV
K13-u	AVsDGVIkVFNDMkV
K19-a	IkVFNDMkVRksstP
K19-u	IkVFNDMkVRksstP
K22-u	FNDMkVRksstPEEV
S23-p	NDMkVRksstPEEVk
S24-p	DMkVRksstPEEVkk
T25-p	MkVRksstPEEVkkR
K30-a	sstPEEVkkRkKAVL
K30-u	sstPEEVkkRkKAVL
K31-a	stPEEVkkRkKAVLF
K31	stPEEVkKRkKAVLF
K33-a	PEEVkkRkKAVLFCL
S41-p	KAVLFCLsEDkkNII
K44-a	LFCLsEDkkNIILEE
K44-u	LFCLsEDkkNIILEE
K45-a	FCLsEDkkNIILEEG
K45-u	FCLsEDkkNIILEEG
K53-u	NIILEEGkEILVGDV
T63-p	LVGDVGQtVDDPyAt
Y68-p	GQtVDDPyAtFVkML
A69	QtVDDPyAtFVkMLP
T70-p	tVDDPyAtFVkMLPD
K73-u	DPyAtFVkMLPDkDC
K73-a	DPyAtFVkMLPDkDC
K78-u	FVkMLPDkDCRyALy
K78-a	FVkMLPDkDCRyALy
Y82-p	LPDkDCRyALyDAty
Y85-p	kDCRyALyDAtyEtk
T88-p	RyALyDAtyEtkESk
Y89-p	yALyDAtyEtkESkk
T91-p	LyDAtyEtkESkkED
K92-u	yDAtyEtkESkkEDL
K95-u	tyEtkESkkEDLVFI
K96-a	yEtkESkkEDLVFIF
K96-m3	yEtkESkkEDLVFIF
K112-u	APESAPLkSkMIyAS
K114-u	ESAPLkSkMIyASSk
Y117-p	PLkSkMIyASSkDAI
K121-a	kMIyASSkDAIkkkL
K121-u	kMIyASSkDAIkkkL
K125-a	ASSkDAIkkkLTGIk
K126-a	SSkDAIkkkLTGIkH
K127-a	SkDAIkkkLTGIkHE
K132-a	kkkLTGIkHELQANC
K132-u	kkkLTGIkHELQANC
Y140-p	HELQANCyEEVkDRC
K144-a	ANCyEEVkDRCTLAE
K144-u	ANCyEEVkDRCTLAE
T148	EEVkDRCTLAEKLGG
S156-p	LAEKLGGsAVISLEG
K164-u	AVISLEGkPL_____

	rat
S3-p	_____MAsGVAVSDG
S8	MAsGVAVSDGVIKVF
K13	AVSDGVIKVFNDMKV
K13	AVSDGVIKVFNDMKV
K19	IKVFNDMKVRKSSTP
K19	IKVFNDMKVRKSSTP
K22	FNDMKVRKSSTPEEV
S23	NDMKVRKSSTPEEVK
S24	DMKVRKSSTPEEVKK
T25	MKVRKSSTPEEVKKR
K30	SSTPEEVKKRKKAVL
K30	SSTPEEVKKRKKAVL
K31	STPEEVKKRKKAVLF
K31	STPEEVKKRKKAVLF
K33	PEEVKKRKKAVLFCL
S41	KAVLFCLSEDKKNII
K44	LFCLSEDKKNIILEE
K44	LFCLSEDKKNIILEE
K45	FCLSEDKKNIILEEG
K45	FCLSEDKKNIILEEG
K53-u	NIILEEGkEILVGDV
T63	LVGDVGQTVDDPyTT
Y68-p	GQTVDDPyTTFVkML
T69	QTVDDPyTTFVkMLP
T70	TVDDPyTTFVkMLPD
K73-u	DPyTTFVkMLPDKDC
K73	DPyTTFVKMLPDKDC
K78	FVkMLPDKDCRYALY
K78	FVkMLPDKDCRYALY
Y82	LPDKDCRYALYDATy
Y85	KDCRYALYDATyETK
T88	RYALYDATyETKESK
Y89-p	YALYDATyETKESKK
T91	LYDATyETKESKKED
K92	YDATyETKESKKEDL
K95	TyETKESKKEDLVFI
K96	yETKESKKEDLVFIF
K96	yETKESKKEDLVFIF
K112-u	APESAPLkSkMIYAS
K114-u	ESAPLkSkMIYASSK
Y117	PLkSkMIYASSKDAI
K121	kMIYASSKDAIKKKL
K121	kMIYASSKDAIKKKL
K125	ASSKDAIKKKLTGIK
K126	SSKDAIKKKLTGIKH
K127	SKDAIKKKLTGIKHE
K132	KKKLTGIKHELQANC
K132	KKKLTGIKHELQANC
Y140-p	HELQANCyEEVKDRC
K144	ANCyEEVKDRCTLAE
K144	ANCyEEVKDRCTLAE
T148	EEVKDRCTLAEKLGG
S156-p	LAEKLGGsAVISLEG
K164	AVISLEGKPL_____

	pig
S3-p	_____MAsGVAVSDG
S8	MAsGVAVSDGVIKVF
K13	AVSDGVIKVFNDMKV
K13	AVSDGVIKVFNDMKV
K19	IKVFNDMKVRKSSTP
K19	IKVFNDMKVRKSSTP
K22	FNDMKVRKSSTPEEV
S23	NDMKVRKSSTPEEVK
S24	DMKVRKSSTPEEVKK
T25	MKVRKSSTPEEVKKR
K30	SSTPEEVKKRKKAVL
K30	SSTPEEVKKRKKAVL
K31	STPEEVKKRKKAVLF
K31	STPEEVKKRKKAVLF
K33	PEEVKKRKKAVLFCL
S41	KAVLFCLSEDKKNII
K44	LFCLSEDKKNIILEE
K44	LFCLSEDKKNIILEE
K45	FCLSEDKKNIILEEG
K45	FCLSEDKKNIILEEG
K53	NIILEEGKEILVGDV
T63	LVGDVGQTVDDPYAT
Y68	GQTVDDPYATFVKML
A69	QTVDDPYATFVKMLP
T70	TVDDPYATFVKMLPD
K73	DPYATFVKMLPDKDC
K73	DPYATFVKMLPDKDC
K78	FVKMLPDKDCRYALY
K78	FVKMLPDKDCRYALY
Y82	LPDKDCRYALYDATY
Y85	KDCRYALYDATYETK
T88	RYALYDATYETKESK
Y89	YALYDATYETKESKK
T91	LYDATYETKESKKED
K92	YDATYETKESKKEDL
K95	TYETKESKKEDLVFI
K96	YETKESKKEDLVFIF
K96	YETKESKKEDLVFIF
K112	APECAPLKSKMIYAS
K114	ECAPLKSKMIYASSK
Y117	PLKSKMIYASSKDAI
K121	KMIYASSKDAIKKKL
K121	KMIYASSKDAIKKKL
K125	ASSKDAIKKKLTGIK
K126	SSKDAIKKKLTGIKH
K127	SKDAIKKKLTGIKHE
K132	KKKLTGIKHELQANC
K132	KKKLTGIKHELQANC
Y140	HELQANCYEEVKDRC
K144	ANCYEEVKDRCTLAE
K144	ANCYEEVKDRCTLAE
T148	EEVKDRCTLAEKLGG
S156	LAEKLGGSAVISLEG
K164	AVISLEGKPL_____

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