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ATG13 (human)

Overview ATG13 an autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. Phosphorylated by ULK1 and ULK2. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 and -2 via C-terminus. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Autophagy; Vesicle protein Cellular Component: cytosol Molecular Function: protein binding; protein kinase binding Biological Process: autophagic vacuole formation Reference #:  O75143 (UniProtKB) Alt. Names/Synonyms: ATG13; Autophagy-related protein 13; FLJ20698; KIAA0652 Gene Symbols: ATG13 Molecular weight: 56,572 Da Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states CST Pathways:  Autophagy Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATG13

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T24	IKFFALKTVQVIVQA
0	1		T204-p	STRQFERtPPIMGII
1	0		S355-p	DTETVSNsSEGRAsP
0	7		S361-p	NsSEGRAsPHDVLET

	mouse
T24-p	IKFFALKtVQVIVQA
T204	STRQFERTPPIMGII
S354	DTETVSNSSEGRAsP
S360-p	NSSEGRAsPHDILET

	rat
T24	IKFFALKTVQVIVQA
T204	STRQFERTPPIMGII
S317	DTETVSNSSEGRASP
S323	NSSEGRASPHDILET

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