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Protein Page:
TH (rat)

Overview
TH an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein; Endoplasmic reticulum; Amino Acid Metabolism - tyrosine; Oxidoreductase; EC 1.14.16.2; Mitochondrial
Cellular Component: internal side of plasma membrane; neuron projection; cytoplasmic vesicle membrane; smooth endoplasmic reticulum; mitochondrion; dendrite; melanosome membrane; terminal button; perikaryon; cytosol; synaptic vesicle; cell soma; axon; cytoplasm; cytoplasmic vesicle; nucleus
Molecular Function: protein domain specific binding; amino acid binding; protein binding; ferric iron binding; ferrous iron binding; dopamine binding; oxygen binding; tyrosine 3-monooxygenase activity; monooxygenase activity
Biological Process: response to nicotine; heart development; response to lipopolysaccharide; dopamine biosynthetic process; response to organic cyclic substance; phytoalexin metabolic process; protein homotetramerization; norepinephrine biosynthetic process; dopamine biosynthetic process from tyrosine; catecholamine biosynthetic process; response to electrical stimulus; epinephrine biosynthetic process; response to pyrethroid; neurotransmitter biosynthetic process; response to corticosterone stimulus; response to drug; response to light stimulus; phthalate metabolic process; mating behavior; social behavior; organ morphogenesis; eye photoreceptor cell development; response to ethanol; circadian sleep/wake cycle; response to zinc ion; response to steroid hormone stimulus; cerebral cortex development; response to activity; response to water deprivation; response to peptide hormone stimulus; synaptic transmission, dopaminergic; response to metal ion; locomotory behavior; fatty acid metabolic process; response to insecticide; response to estradiol stimulus; response to salt stress; regulation of heart contraction; sensory perception of sound; visual perception; glycoside metabolic process; response to nutrient levels; terpene metabolic process; sphingolipid metabolic process; eating behavior; response to amphetamine; multicellular organismal aging; isoquinoline alkaloid metabolic process; learning; response to herbicide; response to ether; synaptic vesicle amine transport; memory; response to hypoxia; embryonic camera-type eye morphogenesis; cognition
Reference #:  P04177 (UniProtKB)
Alt. Names/Synonyms: TH; The; TY3H; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; tyrosine hydroxylase
Gene Symbols: Th
Molecular weight: 55,966 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TH

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S19‑p, S31‑p, S40‑p
molecular association, regulation: S19‑p, S40‑p
protein conformation: S19‑p, S40‑p
protein stabilization: S8‑p, S19‑p, S31‑p, S40‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
5 0 S8-p MPTPSAPsPQPKGFR
37 7 S19-p KGFRRAVsEQDAKQA
35 4 S31-p KQAEAVTsPRFIGRR
51 11 S40-p RFIGRRQsLIEDARK
1 0 S153-p LSSVRRVsDDVRSAR
0 1 Y200 PGFSDQVYRQRRKLI
0 1 Y389 QNGELKAYGAGLLSS
1 0 S405 GELLHSLSEEPEVRA
0 2 S472 LAIDVLDSPHTIQRS
3370 : Phospho-Tyrosine Hydroxylase (Ser31) Antibody
13041 : Phospho-Tyrosine Hydroxylase (Ser31) (D6I9V) Rabbit mAb
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  human

► Hide Isoforms
 
T8 MPTPDATTPQAKGFR
S19-p KGFRRAVsELDAKQA
S62-p SYTPTPRsPRFIGRR
S71-p RFIGRRQsLIEDARK
S183 LSGVRQVSEDVRSPA
Y230-p PGFSDQVyRQRRKLI
Y419-p QNGEVKAyGAGLLSS
S435 GELLHCLSEEPEIRA
S502 LAIDVLDSPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  TH iso2  
T8 MPTPDATTPQAKGFR
S19-p KGFRRAVsELDAKQA
S58-p SYTPTPRsPRFIGRR
S67-p RFIGRRQsLIEDARK
S179 LSGVRQVSEDVRSPA
Y226 PGFSDQVYRQRRKLI
Y415 QNGEVKAYGAGLLSS
S431 GELLHCLSEEPEIRA
S498 LAIDVLDSPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  TH iso3  
T8 MPTPDATTPQAKGFR
S19-p KGFRRAVsELDAKQA
S31-p KQAEAIMsPRFIGRR
S40-p RFIGRRQsLIEDARK
S152 LSGVRQVSEDVRSPA
Y199 PGFSDQVYRQRRKLI
Y388 QNGEVKAYGAGLLSS
S404-p GELLHCLsEEPEIRA
S471 LAIDVLDSPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  TH iso4  
T8 MPTPDATTPQAKGFR
S19-p KGFRRAVsELDAKQA
S35-p AIMVRGQsPRFIGRR
S44-p RFIGRRQsLIEDARK
S156 LSGVRQVSEDVRSPA
Y203 PGFSDQVYRQRRKLI
Y392 QNGEVKAYGAGLLSS
S408 GELLHCLSEEPEIRA
S475 LAIDVLDSPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  mouse

 
S8 MPTPSASSPQPKGFR
S19-p KGFRRAVsEQDTKQA
S31-p KQAEAVTsPRFIGRR
S40-p RFIGRRQsLIEDARK
S153 LSSVRRVSDDVRSAR
Y200 PGFSDQAYRQRRKLI
Y389 QNGELKAYGAGLLSS
S405 GELLHSLSEEPEVRA
S472-p LAIDVLDsPHTIRRS
3370 : Phospho-Tyrosine Hydroxylase (Ser31) Antibody
13041 : Phospho-Tyrosine Hydroxylase (Ser31) (D6I9V) Rabbit mAb
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  cow

 
S8 MPTPNAASPQAKGFR
S19-p KGFRRAVsELDAKQA
S31-p KQAEAIMsPRFVGRR
S40-p RFVGRRQsLIQDARK
A146 LSALRRVAEDVRAAG
Y193 PGFSDQAYRQRRKLI
Y382 QNGEVKAYGAGLLSS
S398 GELLHSLSEEPEIRA
S465 LAIDVLDSPHAIRHA
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