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Protein Page:
SKP1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SKP1A Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110. Component of an E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with phosphorylated NFKBIA and RELA; RELA interacts directly with NFKBIA. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Identified in a complex with SKP2, CKS1B and p27Kip1. Interacts with the cyclin A/CDK2 complex. Part of a SCF- like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Part of several SCF complexes containing SKP1 and one of the F-box proteins. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts with FBXO2, FBXO4, FBXW7 and TRIM21. Interacts with FBXO45. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF. Belongs to the SKP1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Cellular Component: nucleoplasm; SCF ubiquitin ligase complex; PcG protein complex; cytosol
Molecular Function: protein binding; ubiquitin-protein ligase activity
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Notch signaling pathway; viral reproduction; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; mitotic cell cycle; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle
Reference #:  P63208 (UniProtKB)
Alt. Names/Synonyms: cyclin A/CDK2-associated p19; cyclin A/CDK2-associated protein p19; Cyclin-A/CDK2-associated protein p19; EMC19; MGC34403; OCP-2; OCP-II; OCP2; Organ of Corti protein 2; Organ of Corti protein II; p19A; p19skp1; RNA polymerase II elongation factor-like protein; RNA polymerase II elongation factor-like protein OCP2; S-phase kinase-associated protein 1; SIII; SKP1; SKP1A; TCEB1L; Transcription elongation factor B; transcription elongation factor B (SIII), polypeptide 1-like
Gene Symbols: SKP1
Molecular weight: 18,658 Da
Basal Isoelectric point: 4.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SKP1A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K22-ub EVDVEIAkQSVTIKT
0 17 K56-ub NVNAAILkkVIQWCT
0 5 K57-ub VNAAILkkVIQWCTH
0 4 K78 PPEDDENKEKRTDDI
0 1 K80 EDDENKEKRTDDIPV
0 2 K94 VWDQEFLKVDQGTLF
0 12 K128-ub KTVANMIkGktPEEI
0 1 K128-sc KTVANMIkGktPEEI
0 5 K130-ub VANMIkGktPEEIRk
0 16 T131-p ANMIkGktPEEIRkT
0 3 K137-ub ktPEEIRkTFNIkND
0 46 K142-ub IRkTFNIkNDFTEEE
0 14 K155-ub EEEAQVRkENQWCEE
0 5 K163-ac ENQWCEEk_______
0 4 K163-ub ENQWCEEk_______
  mouse

 
K22 EVDVEIAKQSVTIKT
K56-ub NVNAAILkKVIQWCT
K57 VNAAILkKVIQWCTH
K78-ub PPEDDENkEkRTDDI
K80-ub EDDENkEkRTDDIPV
K94-ub VWDQEFLkVDQGTLF
K128-ub KTVANMIkGKtPEEI
K128 KTVANMIKGKtPEEI
K130 VANMIkGKtPEEIRk
T131-p ANMIkGKtPEEIRkT
K137-ub KtPEEIRkTFNIkND
K142-ub IRkTFNIkNDFTEEE
K155-ub EEEAQVRkENQWCEE
K163 ENQWCEEK_______
K163 ENQWCEEK_______
  rat

 
K22 EVDVEIAKQSVTIKT
K56-ub NVNAAILkKVIQWCT
K57 VNAAILkKVIQWCTH
K78 PPEDDENKEKRTDDI
K80 EDDENKEKRTDDIPV
K94 VWDQEFLKVDQGTLF
K128 KTVANMIKGKtPEEI
K128 KTVANMIKGKtPEEI
K130 VANMIKGKtPEEIRK
T131-p ANMIKGKtPEEIRKT
K137 KtPEEIRKTFNIKND
K142 IRKTFNIKNDFTEEE
K155 EEEAQVRKENQWCEE
K163 ENQWCEEK_______
K163 ENQWCEEK_______
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