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Protein Page:
SLC1A3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC1A3 Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Mitochondrial; Transporter; Membrane protein, integral
Cellular Component: cell projection; cell surface; membrane; cell soma; plasma membrane; integral to membrane; fibril
Molecular Function: glutamate binding; high-affinity glutamate transmembrane transporter activity; sodium:dicarboxylate symporter activity; L-glutamate transmembrane transporter activity
Biological Process: response to drug; response to antibiotic; L-glutamate import; synaptic transmission; response to light stimulus; sensory perception of sound; neuron morphogenesis during differentiation; gamma-aminobutyric acid biosynthetic process; auditory behavior; response to wounding; cranial nerve development; neurotransmitter uptake; ion transport; glutamate biosynthetic process; neuromuscular process controlling balance; transmembrane transport; positive regulation of synaptic transmission
Reference #:  P43003 (UniProtKB)
Alt. Names/Synonyms: EA6; EAA1; EAAT1; Excitatory amino acid transporter 1; FLJ25094; GLAST; GLAST-1; GLAST1; SLC1A3; Sodium-dependent glutamate/aspartate transporter 1; solute carrier family 1 (glial high affinity glutamate transporter), member 3; Solute carrier family 1 member 3
Gene Symbols: SLC1A3
Molecular weight: 59,572 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC1A3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K3 _____MTKSNGEEPK
0 1 N35 LAKKKVQNITkEDVK
0 1 K38-ac KKVQNITkEDVKSYL
0 1 K42 NITkEDVKSYLFRNA
0 2 K79 RMSYREVKYFsFPGE
0 1 S82-p YREVKYFsFPGELLM
0 1 K188 NLVEACFKQFKTNYE
0 1 K384 EENNGVDKRVTRFVL
0 1 K503 HLSRHELKNRDVEMG
0 15 S512-p RDVEMGNsVIEENEM
0 2 K520-ub VIEENEMkkPyQLIA
0 2 K521-ub IEENEMkkPyQLIAQ
0 9 Y523-p ENEMkkPyQLIAQDN
0 3 K534-ub AQDNETEkPIDSETk
0 2 K541-ub kPIDSETkM______
  mouse

 
K3-ac _____MTkSNGEEPR
S35-p LAKKKVQsLTKEDVk
K38 KKVQsLTKEDVkSYL
K42-ub sLTKEDVkSYLFRNA
K79 KMSYREVKYFSFPGE
S82 YREVKYFSFPGELLM
K188 NLVEACFKQFKTSYE
K384-ub EENNGVDkRITRFVL
K503-ub HLSRHELkNRDVEMG
S512-p RDVEMGNsVIEENEM
K520-ub VIEENEMkkPyQLIA
K521-ub IEENEMkkPyQLIAQ
Y523-p ENEMkkPyQLIAQDN
K534-ub AQDNEPEkPVADSET
K542-ub PVADSETkM______
  rat

 
K3 _____MTKSNGEEPR
N35 LAKKKVQNITKEDVK
K38 KKVQNITKEDVKSYL
K42 NITKEDVKSYLFRNA
K79-ac KMSYREVkYFSFPGE
S82 YREVkYFSFPGELLM
K188-ac NLVEACFkQFKTSYE
K384 EENNGVDKRITRFVL
K503 HLSRHELKNRDVEMG
S512-p RDVEMGNsVIEENEM
K520 VIEENEMKKPyQLIA
K521 IEENEMKKPyQLIAQ
Y523-p ENEMKKPyQLIAQDN
K534 AQDNEPEKPVADSET
K542 PVADSETKM______
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