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SLC1A3 (human)

Overview SLC1A3 Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Mitochondrial; Transporter Cellular Component: cell surface; cell soma; membrane; basolateral plasma membrane; mitochondrial inner membrane; integral to membrane; fibril; plasma membrane; dendritic spine; synapse Molecular Function: glutamate binding; high-affinity glutamate transmembrane transporter activity; sodium:dicarboxylate symporter activity; L-glutamate transmembrane transporter activity Biological Process: response to drug; response to light stimulus; response to inorganic substance; auditory behavior; cranial nerve development; glutamate biosynthetic process; malate-aspartate shuttle; positive regulation of synaptic transmission; response to antibiotic; synaptic transmission; L-glutamate import; sensory perception of sound; neuron morphogenesis during differentiation; gamma-aminobutyric acid biosynthetic process; response to wounding; neurotransmitter uptake; ion transport; neuromuscular process controlling balance; transmembrane transport Reference #:  P43003 (UniProtKB) Alt. Names/Synonyms: EA6; EAA1; EAAT1; Excitatory amino acid transporter 1; FLJ25094; GLAST; GLAST-1; GLAST1; SLC1A3; Sodium-dependent glutamate/aspartate transporter 1; solute carrier family 1 (glial high affinity glutamate transporter), member 3; Solute carrier family 1 member 3 Gene Symbols: SLC1A3 Molecular weight: 59,572 Da Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SLC1A3

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 600111 612656  |  InnateDB  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K3	_____MTKSNGEEPK
0	1		N35	LAKKKVQNITkEDVK
0	1		K38-a	KKVQNITkEDVKSYL
0	1		K42	NITkEDVKSYLFRNA
0	2		K79-a	RMSYREVkYFSFPGE
0	1		K188-a	NLVEACFkQFKTNYE
0	1		K384	EENNGVDKRVTRFVL
0	1		K503	HLSRHELKNRDVEMG
0	10		S512-p	RDVEMGNsVIEENEM
0	2		K520-u	VIEENEMkkPyQLIA
0	2		K521-u	IEENEMkkPyQLIAQ
0	8		Y523-p	ENEMkkPyQLIAQDN
0	3		K534-u	AQDNETEkPIDSETk
0	2		K541-u	kPIDSETkM______

	mouse
K3-a	_____MTkSNGEEPR
S35-p	LAKKKVQsLTKEDVk
K38	KKVQsLTKEDVkSYL
K42-u	sLTKEDVkSYLFRNA
K79	KMSYREVKYFSFPGE
K188	NLVEACFKQFKTSYE
K384-u	EENNGVDkRITRFVL
K503-u	HLSRHELkNRDVEMG
S512-p	RDVEMGNsVIEENEM
K520-u	VIEENEMkkPyQLIA
K521-u	IEENEMkkPyQLIAQ
Y523-p	ENEMkkPyQLIAQDN
K534-u	AQDNEPEkPVADSET
K542-u	PVADSETkM______

	rat
K3	_____MTKSNGEEPR
N35	LAKKKVQNITKEDVK
K38	KKVQNITKEDVKSYL
K42	NITKEDVKSYLFRNA
K79-a	KMSYREVkYFSFPGE
K188-a	NLVEACFkQFKTSYE
K384	EENNGVDKRITRFVL
K503	HLSRHELKNRDVEMG
S512	RDVEMGNSVIEENEM
K520	VIEENEMKKPyQLIA
K521	IEENEMKKPyQLIAQ
Y523-p	ENEMKKPyQLIAQDN
K534	AQDNEPEKPVADSET
K542	PVADSETKM______

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