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Protein Page:
reelin (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
reelin Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Defects in RELN are the cause of lissencephaly type 2 (LIS2); also known as lissencephaly with cerebellar hypoplasia or Norman-Roberts syndrome. LIS2 is a classic type lissencephaly associated with abnormalities of the cerebellum, hippocampus and brainstem. Individuals with LIS2 are severely ataxic, mentally retarded and suffer from epilepsy. Belongs to the reelin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Cell development/differentiation; EC 3.4.21.-; Secreted; Secreted, signal peptide; Protease
Cellular Component: proteinaceous extracellular matrix; extracellular space; cytoplasm; dendrite
Molecular Function: serine-type peptidase activity; metal ion binding; protein serine/threonine/tyrosine kinase activity
Biological Process: axon guidance; cellular morphogenesis during differentiation; peptidyl-tyrosine phosphorylation; central nervous system development; spinal cord patterning; neuron migration; response to pain; proteolysis; positive regulation of synaptic transmission, glutamatergic; glial cell differentiation; dendrite development; cell adhesion; positive regulation of TOR signaling pathway; associative learning; regulation of behavior; regulation of synaptic transmission; cerebral cortex tangential migration; hippocampus development; activation of CREB transcription factor; ventral spinal cord development; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of small GTPase mediated signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; long-term memory; positive regulation of protein kinase activity; brain development
Reference #:  P78509 (UniProtKB)
Alt. Names/Synonyms: PRO1598; Reelin; RELN; RL
Gene Symbols: RELN
Molecular weight: 388,388 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Select Structure to View Below

reelin

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y29-p RARAAAGyYPRFSPF
0 1 K299-a ADWIQLEkIRAPSNV
0 1 Y471-p PSMDTTGyGNLRFYF
0 2 S764-p LITSFLDsSQSRFLQ
0 1 T773-p QSRFLQFtLRLGSKS
0 1 A1272 KNETFCAATPSAMIF
0 1 K2893 HTLKTFLKERFDSEE
  mouse

 
Y30 RARAATGYYPRFSPF
K300 ADWIQLEKIRAPSNV
Y472 PYMDTTGYGNLRFYF
S765 LITSFLDSSQSRFLQ
T774 QSRFLQFTLRLGSKS
T1273-p KNDSFCAtTPSAMVF
K2894-u HSLKTFLkERFDSEE
  rat

 
Y31 RARAATGYYPRFSPF
K301 ADWIQLEKIRAPSNV
Y473 PYMDTTGYGNLRFYF
S766 LITSFLDSSQSRFLQ
T775 QSRFLQFTLRLGSKS
T1274 KNDSFCATTPSAMVF
K2895 HTLKTFLKERFDSEE
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