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PSME3
a protein implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Homohexamer. Significantly elevated in colorectal cancer patients compared with healthy donors and patients with benign bowel disease. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Proteasome complex; Protease |
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Cellular Component: proteasome complex; nucleoplasm; proteasome activator complex; cytosol
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Molecular Function: protein binding; p53 binding
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Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; M/G1 transition of mitotic cell cycle; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; RNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; S phase of mitotic cell cycle; cell cycle checkpoint; G1/S transition of mitotic cell cycle
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Reference #:
P61289 (UniProtKB)
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| Alt. Names/Synonyms: 11S regulator complex gamma subunit; 11S regulator complex subunit gamma; Activator of multicatalytic protease subunit 3; Ki; Ki antigen; Ki nuclear autoantigen; Ki); PA28-gamma; PA28g; PA28gamma; proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Proteasome activator 28 subunit gamma; proteasome activator 28-gamma; Proteasome activator complex subunit 3; PSME3; REG-gamma |
| Gene Symbols: PSME3 |
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Molecular weight: 29,506 Da
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Basal Isoelectric point: 5.69
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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