The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; EC 18.104.22.168
Chromosomal Location of Human Ortholog: 15q15
Cellular Component: cytosol
Molecular Function: signal transducer activity; calcium ion binding; phospholipase C activity; phosphoinositide phospholipase C activity
Biological Process: synaptic transmission; inositol phosphate metabolic process; phospholipase C activation; metabolic process; phospholipid metabolic process; sensory perception of bitter taste; lipid catabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.