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Protein Page:
PLCB2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PLCB2 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; Phospholipase; EC 3.1.4.11
Cellular Component: Golgi apparatus; plasma membrane; cytosol
Molecular Function: signal transducer activity; G-protein beta/gamma-subunit binding; phospholipid binding; calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity
Biological Process: synaptic transmission; phospholipase C activation; phospholipid metabolic process; detection of chemical stimulus involved in sensory perception of bitter taste; lipid catabolic process
Reference #:  Q00722 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2; FLJ38135; Phosphoinositide phospholipase C-beta-2; phospholipase C, beta 2; Phospholipase C-beta-2; PLC-beta-2; PLCB2
Gene Symbols: PLCB2
Molecular weight: 134,024 Da
Basal Isoelectric point: 5.96  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Regulation of Actin Dynamics
Select Structure to View Below

PLCB2
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 T332-p SSHNTYLtAGQFsGL
0 1 S337-p YLtAGQFsGLSSAEM
0 1 S450-p KPGVPLPsPEDLRGK
0 1 K461 LRGKILIKNKKNQFS
0 1 S472 NQFSGPTSSsKDTGG
0 1 S474-p FSGPTSSsKDTGGEA
0 1 S570-p FSAQKNRsyVIssFT
0 1 Y571-p SAQKNRsyVIssFTE
0 1 S574-p KNRsyVIssFTELKA
0 1 S575-p NRsyVIssFTELKAY
0 1 Y582 sFTELKAYDLLSKAS
0 1 Y595 ASVQFVDYNKRQMsR
0 1 S601-p DYNKRQMsRIyPKGT
0 1 Y604-p KRQMsRIyPKGTRMD
0 1 S672-p DKQFNPFsVDRIDVV
0 1 Y718-p PGDPKRRyRTKLSPS
0 1 K761-u AVMEEGNkFLGHRII
0 1 R874-m1 PAARAGArEEAMKEA
0 1 R893-m1 TASLEELrELKGVVK
0 8 S953-p KLGPGKGsRKKRSLP
0 1 T1035-p ELKALKEtsENDtKE
0 1 S1036-p LKALKEtsENDtKEM
0 1 T1040-p KEtsENDtKEMKKKL
  mouse

 
T332 SSHNTYLTAGQFSGL
S337 YLTAGQFSGLSSAEM
S450 KPGIPLPSPEDLRGK
K461 LRGKILIKNKKNQFS
S472-p NQFSGPAsPSKKPGG
S474 FSGPAsPSKKPGGVA
S571 FSAQKNRSYVVSSFT
Y572 SAQKNRSYVVSSFTE
S575 KNRSYVVSSFTELKA
S576 NRSYVVSSFTELKAY
Y583 SFTELKAYELLSKAS
Y596 ASMQFVDYNKRQMSR
S602 DYNKRQMSRVYPKGT
Y605 KRQMSRVYPKGTRMD
S673 DKQFNPFSVDRIDVV
Y719 PGDPKRRYRTKLSPT
K762 AVMEEGSKFLGHRII
T874 TAPGTKATGEEATKE
R894 TASLEELRELKGVVK
S950 KLRPGKGSRKKRTLP
T1031 ELKTFKETSETDTKE
S1032 LKTFKETSETDTKEM
T1036 KETSETDTKEMKKKL
  rat

 
T332 SSHNTYLTAGQFSGP
S337 YLTAGQFSGPSSAEM
S450 KPGMPLPSPEDLRGK
K461-u LRGKILIkNKKNQFS
S472 NQFSGPASPNKKPDG
- under review  
S574 FSAQKNRSYLVSSFT
Y575 SAQKNRSYLVSSFTE
S578 KNRSYLVSSFTELKA
S579 NRSYLVSSFTELKAy
Y586-p SFTELKAyELLSKAS
Y599-p ASMQFVDyNKRQMSR
S605 DyNKRQMSRVYPKGT
Y608 KRQMSRVYPKGTRMD
S676 DKQFNPFSVDRIDVV
Y722 PGDPKRRYRTKLSPT
K765 AVMEEGGKFIGHRII
K877 TAPGTKAKEEATKEV
R896 TTSLEELRELKGVVK
S952 KLRPGKGSRKKRIVP
T1033 ELKSFKETSETDTKE
S1034 LKSFKETSETDTKEM
T1038 KETSETDTKEMKKKL
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