The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; Phospholipase; EC 220.127.116.11
Molecular Function: signal transducer activity; G-protein beta/gamma-subunit binding; phospholipid binding; calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity
Biological Process: synaptic transmission; phospholipase C activation; phospholipid metabolic process; detection of chemical stimulus involved in sensory perception of bitter taste; lipid catabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.