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Protein Page:
PLCB2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLCB2 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase
Chromosomal Location of Human Ortholog: 15q15
Cellular Component: cytosol
Molecular Function: signal transducer activity; calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity
Biological Process: synaptic transmission; inositol phosphate metabolic process; phospholipase C activation; phospholipid metabolic process; sensory perception of bitter taste; lipid catabolic process
Reference #:  Q00722 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2; FLJ38135; Phosphoinositide phospholipase C-beta-2; phospholipase C, beta 2; Phospholipase C-beta-2; PLC-beta-2; PLCB2
Gene Symbols: PLCB2
Molecular weight: 134,024 Da
Basal Isoelectric point: 5.96  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs
Select Structure to View Below

PLCB2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2-p ______MsLLNPVLL
0 1 Y208-p EDFPEPVyKSFLMSL
0 1 Y274-p VQGLIDKyEPsGINA
0 1 S277-p LIDKyEPsGINAQRG
0 1 T332-p SSHNTYLtAGQFsGL
0 1 S337-p YLtAGQFsGLSSAEM
0 1 S450-p KPGVPLPsPEDLRGK
0 1 K461 LRGKILIKNKKNQFS
0 1 S472 NQFSGPTSSsKDTGG
0 1 S474-p FSGPTSSsKDTGGEA
0 1 S601-p DYNKRQMsRIyPKGT
0 1 Y604-p KRQMsRIyPKGTRMD
0 1 S672-p DKQFNPFsVDRIDVV
0 1 S698-p GQFLSERsVRtYVEV
0 1 T701-p LSERsVRtYVEVELF
0 1 Y718-p PGDPKRRyRTKLSPS
0 1 S728-p KLSPSTNsINPVWKE
0 1 K761-ub AVMEEGNkFLGHRII
0 1 R874-m1 PAARAGArEEAMKEA
0 1 R893-m1 TASLEELrELKGVVK
0 9 S953-p KLGPGKGsRKKRsLP
0 1 S958-p KGsRKKRsLPREESA
0 1 T1035-p ELKALKEtsENDtKE
0 1 S1036-p LKALKEtsENDtKEM
0 1 T1040-p KEtsENDtKEMKKKL
  mouse

 
S2 ______MSLLNPVLL
Y208 EDFPESVYKSFLMSL
Y274 VQVLIDKYEPSGINV
S277 LIDKYEPSGINVQRG
T332 SSHNTYLTAGQFSGL
S337 YLTAGQFSGLSSAEM
S450 KPGIPLPSPEDLRGK
K461 LRGKILIKNKKNQFS
S472-p NQFSGPAsPSKKPGG
S474 FSGPAsPSKKPGGVA
S602 DYNKRQMSRVYPKGT
Y605 KRQMSRVYPKGTRMD
S673 DKQFNPFSVDRIDVV
S699 GQFLSERSVRTYVEV
T702 LSERSVRTYVEVELF
Y719 PGDPKRRYRTKLSPT
S729 KLSPTANSINPVWKE
K762 AVMEEGSKFLGHRII
T874 TAPGTKATGEEATKE
R894 TASLEELRELKGVVK
S950 KLRPGKGSRKKRTLP
T955 KGSRKKRTLPCEETV
T1031 ELKTFKETSETDTKE
S1032 LKTFKETSETDTKEM
T1036 KETSETDTKEMKKKL
  rat

 
S2 ______MSLLNPVLL
Y208 EDFPESVYKSFLMSL
Y274 VQALIDKYEPSGINV
S277 LIDKYEPSGINVQRG
T332 SSHNTYLTAGQFSGP
S337 YLTAGQFSGPSSAEM
S450 KPGMPLPSPEDLRGK
K461-ub LRGKILIkNKKNQFS
S472 NQFSGPASPNKKPDG
N474 FSGPASPNKKPDGVS
S605 DYNKRQMSRVYPKGT
Y608 KRQMSRVYPKGTRMD
S676 DKQFNPFSVDRIDVV
S702 GQFLSERSVRTYVEV
T705 LSERSVRTYVEVELF
Y722 PGDPKRRYRTKLSPT
S732 KLSPTANSINPVWKE
K765 AVMEEGGKFIGHRII
K877 TAPGTKAKEEATKEV
R896 TTSLEELRELKGVVK
S952 KLRPGKGSRKKRIVP
I957 KGSRKKRIVPCEETI
T1033 ELKSFKETSETDTKE
S1034 LKSFKETSETDTKEM
T1038 KETSETDTKEMKKKL
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