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Protein Page:
PLCB2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PLCB2 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; Phospholipase; EC 3.1.4.11
Cellular Component: cytosol
Molecular Function: signal transducer activity; calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity
Biological Process: synaptic transmission; inositol phosphate metabolic process; phospholipase C activation; phospholipid metabolic process; sensory perception of bitter taste; lipid catabolic process
Reference #:  Q00722 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2; FLJ38135; Phosphoinositide phospholipase C-beta-2; phospholipase C, beta 2; Phospholipase C-beta-2; PLC-beta-2; PLCB2
Gene Symbols: PLCB2
Molecular weight: 134,024 Da
Basal Isoelectric point: 5.96  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs
Select Structure to View Below

PLCB2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S472 NQFSGPTSSSKDTGG
0 1 S601-p DYNKRQMsRIyPKGT
0 1 Y604-p KRQMsRIyPKGTRMD
0 1 K761-u AVMEEGNkFLGHRII
0 8 S953-p KLGPGKGsRKKRsLP
0 1 S958-p KGsRKKRsLPREESA
  mouse

 
S472-p NQFSGPAsPSKKPGG
S602 DYNKRQMSRVYPKGT
Y605 KRQMSRVYPKGTRMD
K762 AVMEEGSKFLGHRII
S950 KLRPGKGSRKKRTLP
T955 KGSRKKRTLPCEETV
  rat

 
S472 NQFSGPASPNKKPDG
S605 DYNKRQMSRVYPKGT
Y608 KRQMSRVYPKGTRMD
K765 AVMEEGGKFIGHRII
S952 KLRPGKGSRKKRIVP
I957 KGSRKKRIVPCEETI
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