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Protein Page:
MSX2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MSX2 Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. Defects in MSX2 are the cause of parietal foramina 1 (PFM1); also known as foramina parietalia permagna (FPP). PFM1 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. Defects in MSX2 are the cause of parietal foramina with cleidocranial dysplasia (PFMCCD); also known as cleidocranial dysplasia with parietal foramina. PFMCCD combines skull defects in the form of enlarged parietal foramina and deficient ossification of the clavicles. Defects in MSX2 are the cause of craniosynostosis type 2 (CRS2); also known as craniosynostosis Boston-type (CSB). CRS2 is an autosomal dominant disorder characterized by the premature fusion of calvarial sutures. The craniosynostosis phenotype is either fronto-orbital recession, or frontal bossing, or turribrachycephaly, or cloverleaf skull. Associated features include severe headache, high incidence of visual problems (myopia or hyperopia), and short first metatarsals. Intelligence is normal. Belongs to the Msh homeobox family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component: transcription factor complex; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; transcription cofactor activity; transcription factor binding
Biological Process: embryonic forelimb morphogenesis; transcription from RNA polymerase II promoter; negative regulation of keratinocyte differentiation; chondrocyte development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of catagen; negative regulation of fat cell differentiation; embryonic hindlimb morphogenesis; osteoblast development; anterior/posterior pattern formation; osteoblast differentiation; negative regulation of cell proliferation; positive regulation of osteoblast differentiation; inhibition of CREB transcription factor; negative regulation of transcription, DNA-dependent; anagen; positive regulation of BMP signaling pathway; negative regulation of apoptosis; wound healing, spreading of epidermal cells
Reference #:  P35548 (UniProtKB)
Alt. Names/Synonyms: CRS2; FPP; Homeobox protein Hox-8; Homeobox protein MSX-2; HOX8; MSH; msh homeo box 2; msh homeobox 2; msh homeobox homolog 2; MSX2; PFM; PFM1
Gene Symbols: MSX2
Molecular weight: 28,897 Da
Basal Isoelectric point: 9.68  Predict pI for various phosphorylation states
Select Structure to View Below

MSX2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S91-p HGAREAHsPGPLVKP
1 0 T135-p HMSPTTCtLRKHKtN
1 0 T141-p CtLRKHKtNRKPRTP
0 1 K160-ac QLLALERkFRQkQYL
0 1 K164-ac LERkFRQkQYLSIAE
  mouse

 
S91 HGVRDAHSPGPLVKP
T135 HMSPTTCTLRKHKTN
T141 CTLRKHKTNRKPRTP
K160 QLLALERKFRQKQYL
K164 LERKFRQKQYLSIAE
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