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Protein Page:
MLH1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MLH1 a protein involved in the repair of mismatches in DNA. Binds PMS2 or MLH1 and MLH3. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50- MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with MBD4. Interacts with EXO1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2; Turcot syndrome, an autosomal dominant disorder characterized by malignant tumors of the brain; Muir-Torre syndrome (MTS), a rare autosomal dominant disorder characterized by sebaceous neoplasms and visceral malignancy; lobular carcinoma in situ; endometrial cancer; and non-polyposis colorectal cancer. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Cellular Component: MutLalpha complex; male germ cell nucleus; chiasma; membrane; nucleolus; synaptonemal complex; nucleus
Molecular Function: protein binding; ATPase activity; guanine/thymine mispair binding; MutSalpha complex binding; single-stranded DNA binding; ATP binding
Biological Process: oogenesis; ATP catabolic process; mismatch repair; somatic hypermutation of immunoglobulin genes; negative regulation of mitotic recombination; isotype switching; spindle midzone assembly involved in meiosis; double-strand break repair via nonhomologous end joining; poly(A) tail shortening; meiotic metaphase I plate congression; DNA damage response, signal transduction resulting in induction of apoptosis; synapsis; male meiosis chromosome segregation; resolution of meiotic joint molecules as recombinants; spermatogenesis
Reference #:  P40692 (UniProtKB)
Alt. Names/Synonyms: COCA2; DNA mismatch repair protein Mlh1; FCC2; hMLH1; HNPCC; HNPCC2; MGC5172; MLH1; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); MutL protein homolog 1
Gene Symbols: MLH1
Molecular weight: 84,601 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MLH1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K164 YNIATRRKALkNPSE
0 1 K164-ub YNIATRRkALkNPSE
0 1 K167 ATRRkALKNPSEEYG
0 1 K167-ub ATRRkALkNPSEEYG
0 1 K175 NPSEEYGKILEVVGR
0 1 Y183-p ILEVVGRySVHNAGI
0 1 S184 LEVVGRySVHNAGIS
0 1 K196-ub GISFSVKkQGETVAD
0 1 T212-p RTLPNAStVDNIRSI
0 1 S269 INHRLVESTSLRKAI
0 1 T288-p AAYLPKNtHPFLyLs
0 1 Y293-p KNtHPFLyLsLEISP
0 1 S295-p tHPFLyLsLEISPQN
0 1 K333-ub VQQHIESkLLGSNSS
0 1 S370-p TTSLTSSsTSGSSDK
0 8 Y379-p SGSSDKVyAHQMVRt
0 1 T386-p yAHQMVRtDSREQKL
0 1 K402-ac AFLQPLSkPLSsQPQ
1 0 S406-p PLSkPLSsQPQAIVT
0 1 K443-ac APAEVAAkNQsLEGD
0 1 S446-p EVAAkNQsLEGDTTK
0 3 S467-p EKRGPTSsNPRKRHR
0 1 P469 RGPTSsNPRKRHRED
0 191 S477-p RKRHREDsDVEMVED
0 8 T495-p KEMTAACtPRRRIIN
0 1 S508-p INLTSVLsLQEEINE
0 5 K751-ub ANLPDLYkVFERC__
  mouse

 
K164-ac YNIITRRkALkNPSE
K164 YNIITRRKALkNPSE
K167-ac ITRRkALkNPSEEYG
K167 ITRRkALKNPSEEYG
K175-ac NPSEEYGkILEVVGR
Y183 ILEVVGRYsIHNSGI
S184-p LEVVGRYsIHNSGIS
K196 GISFSVKKQGETVSD
T212 RTLPNATTVDNIRSI
S269-p INHRLVEsAALRKAI
T288 AAYLPKNTHPFLYLS
Y293 KNTHPFLYLSLEISP
S295 THPFLYLSLEISPQN
K333 VQQHIESKLLGSNSS
S370 TTGVASSSTSGSGDK
Y379 SGSGDKVYAYQMVRT
T386 YAYQMVRTDSREQKL
S402 AFLQPVSSLGPSQPQ
S406 PVSSLGPSQPQDPAP
E445 APAEAAAESENLERE
N448 EAAAESENLERESLM
S469-p QKAAPTSsPGSsRKR
S473-p PTSsPGSsRKRHRED
S481-p RKRHREDsDVEMVEN
Y499 KEMTAACYPRRRIIN
S512 INLTSVLSLQEEISE
K755 ANLPDLYKVFERC__
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