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Protein Page:
IL2 (mouse)

Overview
IL2 Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted; Cytokine
Cellular Component: extracellular space; extracellular region
Molecular Function: growth factor activity; interleukin-2 receptor binding; cytokine activity; glycosphingolipid binding; carbohydrate binding; kappa-type opioid receptor binding
Biological Process: positive regulation of interleukin-17 production; positive regulation of isotype switching to IgG isotypes; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; negative regulation of heart contraction; immune system process; positive regulation of immunoglobulin secretion; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; elevation of cytosolic calcium ion concentration; negative regulation of protein amino acid phosphorylation; positive regulation of T cell differentiation; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of inflammatory response; protein kinase C activation; positive regulation of B cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; immune response; positive regulation of protein amino acid phosphorylation; negative regulation of B cell apoptosis
Reference #:  P04351 (UniProtKB)
Alt. Names/Synonyms: IL-2; Il2; interleukin 2; Interleukin-2; OTTMUSP00000007837; T-cell growth factor; TCGF
Gene Symbols: Il2
Molecular weight: 19,400 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
Select Structure to View Below

IL2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S8 MYSMQLASCVTLTLV
0 3 Y79 RMLTFKFYLPKQATE
  human

 
S8-p MYRMQLLsCIALSLA
Y65-p RMLTFKFyMPKKATE
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