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IL2 (mouse)

Overview IL2 Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Note: This description may include information from UniProtKB. Protein type: Cytokine; Secreted, signal peptide; Secreted Cellular Component: extracellular space; extracellular region Molecular Function: growth factor activity; interleukin-2 receptor binding; cytokine activity; carbohydrate binding; glycosphingolipid binding; kappa-type opioid receptor binding Biological Process: positive regulation of interleukin-17 production; positive regulation of isotype switching to IgG isotypes; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; negative regulation of heart contraction; positive regulation of immunoglobulin secretion; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of interferon-gamma production; negative regulation of protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of T cell differentiation; negative regulation of inflammatory response; protein kinase C activation; positive regulation of B cell proliferation; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of T cell proliferation; positive regulation of protein amino acid phosphorylation; negative regulation of B cell apoptosis Reference #:  P04351 (UniProtKB) Alt. Names/Synonyms: IL-2; Il2; interleukin 2; Interleukin-2; OTTMUSP00000007837; T-cell growth factor; TCGF Gene Symbols: Il2 Molecular weight: 19,400 Da Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states

Select Structure to View Below IL2 1ILM - 2=26-153 (human) 1ILN - 2=26-153 (human) 1IRL - A=21-153 (human) 1M47 - A=21-153 (human) 1M48 - A/B=21-153 (human) 1M49 - A/B=21-153 (human) 1M4A - A=21-153 (human) 1M4B - A=21-153 (human) 1M4C - A/B=21-153 (human) 1NBP - A=21-153 (human) 1PW6 - A/B=21-153 (human) 1PY2 - A/B/C/D=21-152 (human) 1QVN - A/B/C/D=21-152 (human) 1Z92 - A=21-153 (human) 2B5I - A=21-153 (human) 2ERJ - D/H=21-153 (human) 3INK - C/D=21-153 (human) 3QAZ - e/S/A/J/P/Y/V/h/M/D/b/G=21-153 (human) 3QB1 - F/A/E/B/H/C/D/G=21-153 (human)

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		S8	MYSMQLASCVTLTLV
0	3		Y79	RMLTFKFYLPKQATE

	human
S8-p	MYRMQLLsCIALSLA
Y65-p	RMLTFKFyMPKKATE

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