Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Cytokine
Cellular Component: extracellular space; extracellular region
Biological Process: positive regulation of interleukin-17 production; positive regulation of isotype switching to IgG isotypes; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; negative regulation of heart contraction; positive regulation of immunoglobulin secretion; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; elevation of cytosolic calcium ion concentration; positive regulation of T cell differentiation; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of protein amino acid phosphorylation; negative regulation of inflammatory response; protein kinase C activation; positive regulation of B cell proliferation; immune response; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of B cell apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.