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IL2 (human)

Overview IL2 Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide; Cytokine Cellular Component: extracellular space; extracellular region Molecular Function: growth factor activity; interleukin-2 receptor binding; cytokine activity; kinase activator activity; glycosphingolipid binding; carbohydrate binding; kappa-type opioid receptor binding Biological Process: positive regulation of isotype switching to IgG isotypes; negative regulation of heart contraction; natural killer cell activation; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; elevation of cytosolic calcium ion concentration; negative regulation of protein amino acid phosphorylation; cell-cell signaling; positive regulation of cell proliferation; protein kinase C activation; positive regulation of B cell proliferation; cell adhesion; T cell differentiation; positive regulation of interleukin-17 production; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; positive regulation of immunoglobulin secretion; positive regulation of cell growth; positive regulation of interferon-gamma production; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of inflammatory response; immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of B cell apoptosis; positive regulation of inflammatory response; negative regulation of apoptosis Reference #:  P60568 (UniProtKB) Alt. Names/Synonyms: aldesleukin; IL-2; IL2; interleukin 2; Interleukin-2; involved in regulation of T-cell clonal expansion; lymphokine; T cell growth factor; T-cell growth factor; TCGF Gene Symbols: IL2 Molecular weight: 17,628 Da Basal Isoelectric point: 7.67  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IL2 1ILM - 2=26-153 (human) 1ILN - 2=26-153 (human) 1IRL - A=21-153 (human) 1M47 - A=21-153 (human) 1M48 - A/B=21-153 (human) 1M49 - A/B=21-153 (human) 1M4A - A=21-153 (human) 1M4B - A=21-153 (human) 1M4C - A/B=21-153 (human) 1NBP - A=21-153 (human) 1PW6 - A/B=21-153 (human) 1PY2 - A/B/C/D=21-152 (human) 1QVN - A/B/C/D=21-152 (human) 1Z92 - A=21-153 (human) 2B5I - A=21-153 (human) 2ERJ - D/H=21-153 (human) 3INK - C/D=21-153 (human) 3QAZ - e/S/A/J/P/Y/V/h/M/D/b/G=21-153 (human) 3QB1 - F/A/E/B/H/C/D/G=21-153 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1ILM 1ILN 1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S8-p	MYRMQLLsCIALSLA
0	3		Y65-p	RMLTFKFyMPKKATE

	mouse
S8	MYSMQLASCVTLTLV
Y79	RMLTFKFYLPKQATE

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