Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Secreted, signal peptide; Cytokine; Secreted
Biological Process: axon guidance; positive regulation of isotype switching to IgG isotypes; negative regulation of heart contraction; activation of MAPKK activity; nerve growth factor receptor signaling pathway; natural killer cell activation; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; elevation of cytosolic calcium ion concentration; negative regulation of protein amino acid phosphorylation; cell-cell signaling; small GTPase mediated signal transduction; positive regulation of cell proliferation; protein kinase C activation; positive regulation of B cell proliferation; cell adhesion; T cell differentiation; positive regulation of interleukin-17 production; epidermal growth factor receptor signaling pathway; regulation of T cell homeostatic proliferation; adaptive immune response; fibroblast growth factor receptor signaling pathway; positive regulation of regulatory T cell differentiation; MAPKKK cascade; positive regulation of immunoglobulin secretion; positive regulation of cell growth; positive regulation of tissue remodeling; positive regulation of interferon-gamma production; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of inflammatory response; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; immune response; positive regulation of transcription from RNA polymerase II promoter; vascular endothelial growth factor receptor signaling pathway; negative regulation of B cell apoptosis; positive regulation of inflammatory response; negative regulation of apoptosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.