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CYR61 (human)

Overview CYR61 Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Secreted Cellular Component: extracellular region Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding; extracellular matrix binding Biological Process: extracellular matrix organization and biogenesis; anatomical structure morphogenesis; positive regulation of apoptosis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; positive regulation of osteoblast differentiation; cell proliferation; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; positive regulation of protein amino acid phosphorylation; positive regulation of BMP signaling pathway; negative regulation of apoptosis; positive regulation of cell migration Reference #:  O00622 (UniProtKB) Alt. Names/Synonyms: CCN family member 1; CCN1; CYR61; Cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, angiogenic inducer, 61; cysteine-rich, anigogenic inducer, 61; GIG1; IBP-10; IGF-binding protein 10; IGFBP-10; IGFBP10; Insulin-like growth factor-binding protein 10; Protein CYR61; Protein GIG1 Gene Symbols: CYR61 Molecular weight: 42,027 Da Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CYR61

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T14-p	RALALVVtLLHLTRL
0	1		S84-p	ECNFGASstALKGIC
0	1		T85-p	CNFGASstALKGICR
0	1		S344	CEDGETFSKNVMMIQ

	mouse
T14	RTLAVAVTLLHLTRL
S84	ECNFGASSTALKGIC
T85	CNFGASSTALKGICR
S342-p	CEDGEMFsKNVMMIQ

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