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Protein Page:
IL1B (human)

IL1B Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Monomer. Belongs to the IL-1 family. Note: This description may include information from UniProtKB.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 2q14
Cellular Component: extracellular space; extracellular region; cytosol; secretory granule
Molecular Function: protein domain specific binding; interleukin-1 receptor binding; cytokine activity
Biological Process: stimulatory C-type lectin receptor signaling pathway; positive regulation of granulocyte macrophage colony-stimulating factor production; negative regulation of MAP kinase activity; positive regulation of JNK activity; positive regulation of nitric oxide biosynthetic process; negative regulation of glutamate secretion; glycoprotein metabolic process; positive regulation of apoptosis; activation of MAPK activity; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; germ cell programmed cell death; negative regulation of insulin receptor signaling pathway; positive regulation of lipid catabolic process; positive regulation of NF-kappaB import into nucleus; fever; positive regulation of membrane protein ectodomain proteolysis; activation of NF-kappaB transcription factor; elevation of cytosolic calcium ion concentration; response to vitamin D; cell-cell signaling; pentacyclic triterpenoid metabolic process; positive regulation of phagocytosis; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; positive regulation of astrocyte differentiation; neutrophil chemotaxis; positive regulation of heterotypic cell-cell adhesion; positive regulation of mitosis; smooth muscle adaptation; interleukin-1 beta production; positive regulation of interleukin-6 production; social behavior; purine base metabolic process; positive regulation of angiogenesis; negative regulation of neuron differentiation; response to ethanol; response to heat; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of lipid metabolic process; response to peptide hormone stimulus; estrogen metabolic process; sequestering of triacylglycerol; positive regulation of histone phosphorylation; wound healing; apoptosis; positive regulation of interleukin-6 biosynthetic process; response to morphine; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to L-ascorbic acid; chronic inflammatory response to antigenic stimulus; response to estradiol stimulus; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of protein export from nucleus; negative regulation of cell proliferation; negative regulation of lipid catabolic process; hyaluronan biosynthetic process; lipopolysaccharide-mediated signaling pathway; protein kinase B signaling cascade; response to gamma radiation; regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response; aging; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; positive regulation of immature T cell proliferation in the thymus; response to ATP; memory; ovulation; polyketide metabolic process; positive regulation of interferon-gamma production; inflammatory response to antigenic stimulus; positive regulation of chemokine biosynthetic process; response to ozone; positive regulation of prostaglandin secretion; response to hypoxia; positive regulation of fever; innate immune response; positive regulation of histone acetylation; positive regulation of protein amino acid phosphorylation; regulation of insulin secretion; embryo implantation
Disease: Gastric Cancer, Hereditary Diffuse
Reference #:  P01584 (UniProtKB)
Alt. Names/Synonyms: Catabolin; IL-1; IL-1 beta; IL1-BETA; IL1B; IL1F2; interleukin 1, beta; Interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta
Gene Symbols: IL1B
Molecular weight: 30,748 Da
Basal Isoelectric point: 4.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 1 S269-p FTMQFVSs_______

S269 FTMESVSS_______

S268 FTMEPVSS_______
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