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Protein Page:
ENPEP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ENPEP Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells. Belongs to the peptidase M1 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.11.7; Protease; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: integral to plasma membrane; apical part of cell; lysosomal membrane; apical plasma membrane; plasma membrane; cytoplasmic vesicle; brush border; external side of plasma membrane
Molecular Function: metallopeptidase activity; zinc ion binding; aminopeptidase activity
Biological Process: cell proliferation; cell migration; cellular protein metabolic process; cell-cell signaling; angiotensin catabolic process in blood; angiogenesis; proteolysis; angiotensin maturation; glomerulus development; regulation of systemic arterial blood pressure by renin-angiotensin
Reference #:  Q07075 (UniProtKB)
Alt. Names/Synonyms: Aminopeptidase A; AMPE; AP-A; APA; CD249; Differentiation antigen gp160; EAP; ENPEP; Glutamyl aminopeptidase; glutamyl aminopeptidase (aminopeptidase A); gp160
Gene Symbols: ENPEP
Molecular weight: 109,244 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
Select Structure to View Below

ENPEP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T139 LWLHLRETRITRLPE
0 1 S151-p LPELKRPsGDQVQVR
0 1 Y701-p RVISAVTyIISMFED
0 1 A736 DSLGWNDAGDHVTKL
0 1 K827 LYGLASVKNVtLLSR
0 1 T830-p LASVKNVtLLSRYLD
  mouse

 
T131 LWLHIRETKITKLPE
S143 LPELRRPSGEQVPIR
Y692 RVISSVSYIISMFED
T727-p DLLGWQDtGSHITKL
K818-sc LYGLASVkDVKLLAR
K821 LASVkDVKLLARYLE
  rat

 
T131-p LWLHIREtRITKLPE
S143 LPELRRPSGEQVPIR
Y692 RVISAVSYIISMFED
T727 DSLGWQDTGSHITKL
K818 LYGLASVKDVTLLAR
T821 LASVKDVTLLARYLE
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