Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells. Belongs to the peptidase M1 family. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: integral to plasma membrane; lysosomal membrane; apical part of cell; apical plasma membrane; plasma membrane; cytoplasmic vesicle; brush border; external side of plasma membrane
Molecular Function: metallopeptidase activity; zinc ion binding; aminopeptidase activity
Biological Process: cell proliferation; cell migration; cellular protein metabolic process; cell-cell signaling; angiotensin catabolic process in blood; angiogenesis; angiotensin maturation; proteolysis; regulation of systemic arterial blood pressure by renin-angiotensin; glomerulus development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.