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Protein Page:
DLL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DLL1 Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; cytoplasmic vesicle
Molecular Function: protein binding; calcium ion binding; Notch binding
Biological Process: regulation of cell adhesion; Notch signaling pathway; negative regulation of myeloid cell differentiation; negative regulation of interleukin-10 production; Notch receptor processing; cell fate determination; compartment specification; somite specification; cell-cell signaling; negative regulation of auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; heart looping; determination of left/right symmetry; cell differentiation; inner ear development; positive regulation of Notch signaling pathway
Reference #:  O00548 (UniProtKB)
Alt. Names/Synonyms: Delta; delta-like 1 (Drosophila); delta-like 1 protein; Delta-like protein 1; Delta1; DL1; DLL1; Drosophila Delta homolog 1; H-Delta-1
Gene Symbols: DLL1
Molecular weight: 78,056 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DLL1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K35-ac KLQEFVNkKGLLGNR
0 1 R57 GPPPCACRTFFRVCL
0 1 S603-p CQREKDIsVSIIGAT
1 1 A638 GFKARYPAVDyNLVQ
0 3 Y641-p ARYPAVDyNLVQDLK
1 1 S694 SERKRPDSGCSTSKD
1 1 S697 KRPDSGCSTSKDtKy
0 1 T702-p GCSTSKDtKyQsVYV
0 1 Y704-p STSKDtKyQsVYVIS
0 1 S706-p SKDtKyQsVYVISEE
  mouse

 
K35 KLQEFVNKKGLLGNR
R56-m1 SGPPCACrTFFRVCL
S603 CQREKDVSVSIIGAT
T638-p SFKVRYPtVDYNLVR
Y641 VRYPtVDYNLVRDLK
S693-p PDRKRPEsVYsTSKD
S696-p KRPEsVYsTSKDTKY
T701 VYsTSKDTKYQSVYV
Y703 sTSKDTKYQSVYVLS
S705 SKDTKYQSVYVLSAE
  rat

 
K35 KLQEFVNKKGLLGNR
R56 SGPPCACRTFFRVCL
S595 CQREKDVSVSIIGAT
T630 SFKARYPTVDYNLIR
Y633 ARYPTVDYNLIRDLK
S685 PDRKRPESVYSTSKD
S688 KRPESVYSTSKDTKY
T693 VYSTSKDTKYQSVYV
Y695 STSKDTKYQSVYVLS
S697 SKDTKYQSVYVLSAE
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