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DLL1
Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell development/differentiation |
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Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; cytoplasmic vesicle
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Molecular Function: protein binding; calcium ion binding; Notch binding
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Biological Process: regulation of cell adhesion; Notch signaling pathway; negative regulation of myeloid cell differentiation; Notch receptor processing; cell fate determination; compartment specification; somite specification; cell-cell signaling; negative regulation of auditory receptor cell differentiation; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; heart looping; cell differentiation; determination of left/right symmetry; inner ear development; positive regulation of Notch signaling pathway
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Reference #:
O00548 (UniProtKB)
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| Alt. Names/Synonyms: Delta; delta-like 1 (Drosophila); delta-like 1 protein; Delta-like protein 1; Delta1; DL1; DLL1; Drosophila Delta homolog 1; H-Delta-1 |
| Gene Symbols: DLL1 |
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Molecular weight: 78,056 Da
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Basal Isoelectric point: 5.85
Predict pI for various phosphorylation states
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CST Pathways:
Notch Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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