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Protein Page:
DLL1 (human)

Overview
DLL1 Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell development/differentiation
Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; cytoplasmic vesicle
Molecular Function: protein binding; calcium ion binding; Notch binding
Biological Process: regulation of cell adhesion; Notch signaling pathway; negative regulation of myeloid cell differentiation; negative regulation of interleukin-10 production; Notch receptor processing; cell fate determination; compartment specification; somite specification; cell-cell signaling; negative regulation of auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; heart looping; cell differentiation; determination of left/right symmetry; inner ear development; positive regulation of Notch signaling pathway
Reference #:  O00548 (UniProtKB)
Alt. Names/Synonyms: Delta; delta-like 1 (Drosophila); delta-like 1 protein; Delta-like protein 1; Delta1; DL1; DLL1; Drosophila Delta homolog 1; H-Delta-1
Gene Symbols: DLL1
Molecular weight: 78,056 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DLL1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 A638 GFKARYPAVDyNLVQ
0 3 Y641-p ARYPAVDyNLVQDLK
1 0 S694 SERKRPDSGCSTSKD
1 0 S697 KRPDSGCSTSKDTKy
0 1 Y704-p STSKDTKyQsVYVIS
0 1 S706-p SKDTKyQsVYVISEE
  mouse

 
T638-p SFKVRYPtVDYNLVR
Y641 VRYPtVDYNLVRDLK
S693-p PDRKRPEsVYsTSKD
S696-p KRPEsVYsTSKDTKY
Y703 sTSKDTKYQSVYVLS
S705 SKDTKYQSVYVLSAE
  rat

 
T630 SFKARYPTVDYNLIR
Y633 ARYPTVDYNLIRDLK
S685 PDRKRPESVYSTSKD
S688 KRPESVYSTSKDTKY
Y695 STSKDTKYQSVYVLS
S697 SKDTKYQSVYVLSAE
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