Home

CYP1A1 (human)

Overview CYP1A1 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB. Protein type: Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - retinol Cellular Component: endoplasmic reticulum membrane; mitochondrion Molecular Function: flavonoid 3'-monooxygenase activity; oxidoreductase activity, acting on diphenols and related substances as donors; enzyme binding; electron carrier activity; iron ion binding; heme binding; oxidoreductase activity; steroid hydroxylase activity; oxygen binding; demethylase activity Biological Process: positive regulation of S phase of mitotic cell cycle; coumarin metabolic process; response to nematode; response to arsenic; response to lipopolysaccharide; cellular lipid metabolic process; response to organic cyclic substance; response to vitamin A; response to antibiotic; embryonic development ending in birth or egg hatching; flavonoid metabolic process; porphyrin metabolic process; response to wounding; drug metabolic process; response to drug; response to food; insecticide metabolic process; camera-type eye development; response to iron(III) ion; response to virus; response to herbicide; vitamin D metabolic process; dibenzo-p-dioxin catabolic process; cell proliferation; response to hyperoxia; gut development; xenobiotic metabolic process; maternal process involved in parturition; 9-cis-retinoic acid biosynthetic process; response to hypoxia; amine metabolic process; hydrogen peroxide biosynthetic process Reference #:  P04798 (UniProtKB) Alt. Names/Synonyms: AHH; AHRR; aryl hydrocarbon hydroxylase; CP11; CP1A1; CYP1; CYP1A1; CYPIA1; cytochrome P1-450, dioxin-inducible; Cytochrome P450 1A1; Cytochrome P450 form 6; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; flavoprotein-linked monooxygenase; P1-450; P450-C; P450DX; xenobiotic monooxygenase Gene Symbols: CYP1A1 Molecular weight: 58,165 Da Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states

Select Structure to View Below CYP1A1 4I8V - A/D/C/B=35-512 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  DISEASE  |  InnateDB  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		P31	WVIRASRPQVPKGLK
0	2		R93	LSGLDTIRQALVRQG
0	2		K104	VRQGDDFKGRPDLYT
0	1		S247-p	LRYLPNPsLNAFKDL
0	1		Y270-p	QKMVKEHykTFEKGH
0	1		K271-u	KMVKEHykTFEKGHI
0	1		S360-p	RSRRPRLsDRSHLPY

	mouse
T35-p	WVVRATRtWVPKGLK
K97-u	LSGLNTIkQALVRQG
K108-a	VRQGDDFkGRPDLYS
S251	LRYLPNSSLDAFKDL
Y274	KKLIKEHYRTFEKGH
R275	KLIKEHYRTFEKGHI
S364	RDRQPRLSDRPQLPY

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.