Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 22.214.171.124; Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - retinol
Molecular Function: flavonoid 3'-monooxygenase activity; oxidoreductase activity, acting on diphenols and related substances as donors; enzyme binding; electron carrier activity; iron ion binding; heme binding; oxidoreductase activity; steroid hydroxylase activity; oxygen binding; demethylase activity
Biological Process: positive regulation of S phase of mitotic cell cycle; coumarin metabolic process; response to nematode; response to arsenic; response to lipopolysaccharide; cellular lipid metabolic process; response to organic cyclic substance; response to vitamin A; response to antibiotic; embryonic development ending in birth or egg hatching; flavonoid metabolic process; porphyrin metabolic process; response to wounding; drug metabolic process; response to drug; response to food; insecticide metabolic process; camera-type eye development; response to iron(III) ion; response to virus; response to herbicide; vitamin D metabolic process; dibenzo-p-dioxin catabolic process; cell proliferation; response to hyperoxia; gut development; xenobiotic metabolic process; maternal process involved in parturition; 9-cis-retinoic acid biosynthetic process; response to hypoxia; amine metabolic process; hydrogen peroxide biosynthetic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.