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Protein Page:
CYP1A1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CYP1A1 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.14.14.1; Oxidoreductase; Amino Acid Metabolism - tryptophan
Cellular Component: endoplasmic reticulum membrane; mitochondrion
Molecular Function: oxidoreductase activity, acting on diphenols and related substances as donors; flavonoid 3'-monooxygenase activity; enzyme binding; iron ion binding; heme binding; steroid hydroxylase activity; oxidoreductase activity; oxygen binding; demethylase activity
Biological Process: coumarin metabolic process; response to nematode; response to arsenic; response to lipopolysaccharide; cellular lipid metabolic process; response to vitamin A; response to antibiotic; embryonic development ending in birth or egg hatching; flavonoid metabolic process; porphyrin metabolic process; response to wounding; arachidonic acid metabolic process; drug metabolic process; aging; response to drug; response to food; insecticide metabolic process; camera-type eye development; response to iron(III) ion; response to virus; epoxygenase P450 pathway; response to herbicide; dibenzo-p-dioxin catabolic process; vitamin D metabolic process; cell proliferation; response to hyperoxia; gut development; xenobiotic metabolic process; maternal process involved in parturition; 9-cis-retinoic acid biosynthetic process; response to hypoxia; amine metabolic process; hydrogen peroxide biosynthetic process
Reference #:  P04798 (UniProtKB)
Alt. Names/Synonyms: AHH; AHRR; aryl hydrocarbon hydroxylase; CP11; CP1A1; CYP1; CYP1A1; CYPIA1; cytochrome P1-450, dioxin-inducible; Cytochrome P450 1A1; Cytochrome P450 form 6; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; flavoprotein-linked monooxygenase; P1-450; P450-C; P450DX
Gene Symbols: CYP1A1
Molecular weight: 58,165 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Select Structure to View Below

CYP1A1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 P31 WVIRASRPQVPKGLK
0 2 R93 LSGLDTIRQALVRQG
0 3 K104 VRQGDDFKGRPDLYT
0 1 S247-p LRYLPNPsLNAFKDL
0 1 Y270-p QKMVKEHykTFEKGH
0 1 K271-ub KMVKEHykTFEKGHI
0 1 S360-p RSRRPRLsDRSHLPY
  mouse

 
T35-p WVVRATRtWVPKGLK
K97-ub LSGLNTIkQALVRQG
K108-ac VRQGDDFkGRPDLYS
S251 LRYLPNSSLDAFKDL
Y274 KKLIKEHYRTFEKGH
R275 KLIKEHYRTFEKGHI
S364 RDRQPRLSDRPQLPY
  rat

 
T35 WVVRVTRTWVPKGLK
K97 LSGLNTIKQALVKQG
K108 VKQGDDFKGRPDLYS
S251 LRYLPNSSLDAFKDL
Y274 KKLIKEHYRTFEKGH
R275 KLIKEHYRTFEKGHI
S364 RDRQPRLSDRPQLPY
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