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CTSB (human)

Overview CTSB Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family. Note: This description may include information from UniProtKB. Protein type: Autophagy; EC 3.4.22.1; Motility/polarity/chemotaxis; Protease Cellular Component: extracellular space; intracellular membrane-bound organelle; mitochondrion; perinuclear region of cytoplasm; lysosome; apical plasma membrane; melanosome; nucleolus; caveola; intracellular; sarcolemma; external side of plasma membrane Molecular Function: peptidase activity; protein binding; cysteine-type endopeptidase activity; kininogen binding; peptide binding; cysteine-type peptidase activity Biological Process: response to peptide hormone stimulus; skeletal muscle development; proteolysis; response to organic cyclic substance; regulation of apoptosis; response to ethanol; regulation of catalytic activity; response to mechanical stimulus; response to wounding; response to glucose stimulus; innate immune response; autophagy; response to amine stimulus Reference #:  P07858 (UniProtKB) Alt. Names/Synonyms: amyloid precursor protein secretase; APP secretase; APPS; CATB; Cathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; Cathepsin B1; CPSB; CTSB; cysteine protease Gene Symbols: CTSB Molecular weight: 37,822 Da Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CTSB 1CSB - A/D=80-126, B/E=129-333 (human) 1GMY - A/B/C=79-339 (human) 1HUC - A/C=80-126, B/D=129-333 (human) 1PBH - A=18-333 (human) 2IPP - A=80-126, B=129-333 (human) 2PBH - A=18-333 (human) 3AI8 - A/B=78-333 (human) 3CBJ - A=74-339 (human) 3CBK - A=74-339 (human) 3K9M - A/B=80-333 (human) 3PBH - A=18-333 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH  |  ENZYME  |  Phospho3D  |  DISEASE  |  InnateDB  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y33-p	LSDELVNyVNKRNTT
0	1		D77-ca	QRVMFTEdLKLPASF
0	1		S169-p	WTRKGLVsGGLyESH
0	1		Y173-p	GLVsGGLyESHVGCR
0	2		Y215-p	SKICEPGySPTyKQD
0	2		Y219-p	EPGySPTyKQDkHYG
0	1		K220	PGySPTyKQDkHYGY
0	1		K223-u	SPTyKQDkHYGYNSY
0	1		K237-u	YSVSNSEkDIMAEIY
0	1		K311	WGDNGFFKILRGQDH

	mouse
Y33	LSDDLINYINKQNTT
D77	GRVAFGEDIDLPETF
S169	WTKKGLVSGGVYNSH
Y173	GLVSGGVYNSHVGCL
Y215	NKSCEAGYSPSYkED
Y219	EAGYSPSYkEDKHFG
K220-u	AGYSPSYkEDKHFGY
K223	SPSYkEDKHFGYTSY
K237	YSVSNSVKEIMAEIY
K311-a	WGDNGFFkILRGENH

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