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Protein Page:
CTSB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CTSB Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Protease; Motility/polarity/chemotaxis; EC 3.4.22.1
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: extracellular space; intracellular membrane-bound organelle; mitochondrion; lysosome; perinuclear region of cytoplasm; extracellular region; nucleolus; melanosome; intracellular
Molecular Function: peptidase activity; collagen binding; proteoglycan binding; protein binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: regulation of apoptosis; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; proteolysis involved in cellular protein catabolic process; epithelial cell differentiation; regulation of catalytic activity; toll-like receptor signaling pathway; innate immune response; proteolysis
Reference #:  P07858 (UniProtKB)
Alt. Names/Synonyms: amyloid precursor protein secretase; APP secretase; APPS; CATB; Cathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; Cathepsin B1; CPSB; CTSB; cysteine protease
Gene Symbols: CTSB
Molecular weight: 37,822 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTSB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y33-p LSDELVNyVNKRNTT
0 1 D77-ca QRVMFTEdLKLPASF
0 1 S107 RDQGSCGSCWAFGAV
0 1 S169-p WTRKGLVsGGLyESH
0 1 Y173-p GLVsGGLyESHVGCR
0 2 Y215-p SKICEPGySPTyKQD
0 2 Y219-p EPGySPTyKQDkHYG
0 1 K220 PGySPTyKQDkHYGY
0 1 K223-ub SPTyKQDkHYGYNSY
0 1 K237-ub YSVSNSEkDIMAEIY
0 1 K311 WGDNGFFKILRGQDH
  mouse

 
Y33 LSDDLINYINKQNTT
D77 GRVAFGEDIDLPETF
S107-p RDQGSCGsCWAFGAV
S169 WTKKGLVSGGVYNSH
Y173 GLVSGGVYNSHVGCL
Y215 NKSCEAGYSPSYkED
Y219 EAGYSPSYkEDKHFG
K220-ub AGYSPSYkEDKHFGY
K223 SPSYkEDKHFGYTSY
K237 YSVSNSVKEIMAEIY
K311-ac WGDNGFFkILRGENH
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