Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family. Note: This description may include information from UniProtKB.
Protein type: Autophagy; EC 220.127.116.11; Motility/polarity/chemotaxis; Protease
Cellular Component: extracellular space; intracellular membrane-bound organelle; mitochondrion; perinuclear region of cytoplasm; lysosome; apical plasma membrane; melanosome; nucleolus; caveola; intracellular; sarcolemma; external side of plasma membrane
Biological Process: response to peptide hormone stimulus; skeletal muscle development; proteolysis; response to organic cyclic substance; regulation of apoptosis; response to ethanol; regulation of catalytic activity; response to mechanical stimulus; response to wounding; response to glucose stimulus; innate immune response; autophagy; response to amine stimulus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.