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Protein Page:
IFITM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IFITM1 IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. Belongs to the CD225/Dispanin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell cycle regulation; Membrane protein, multi-pass
Cellular Component: membrane; integral to membrane; plasma membrane
Molecular Function: protein binding; receptor signaling protein activity
Biological Process: negative regulation of cell proliferation; positive regulation of osteoblast differentiation; regulation of immune response; ossification; cell surface receptor linked signal transduction; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; response to virus; cytokine and chemokine mediated signaling pathway; negative regulation of cell migration; defense response to virus
Reference #:  P13164 (UniProtKB)
Alt. Names/Synonyms: 9-27; CD225; IFI17; IFITM1; IFM1; interferon-induced protein 17; interferon-induced transmembrane protein 1; Leu-13 antigen; LEU13; nterferon-inducible protein 9-27
Gene Symbols: IFITM1
Molecular weight: 13,964 Da
Basal Isoelectric point: 7.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IFITM1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

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 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S16-p AVLGPPPsTILPRST
0 4 K67-ub SVKSRDRkMVGDVTG
  mouse

 
S17 VLGSPHISTSATATT
K66 SVKSRDRKMVGDTTG
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