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Protein Page:
K8 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
K8 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Phsophorylated by p38 kinase, regulating cellular keratin filament reorganization. Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Mutation of this protein is a risk factor for cryptogenic liver failure. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: nucleoplasm; dystrophin-associated glycoprotein complex; intermediate filament cytoskeleton; nuclear matrix; costamere; cytoplasm; keratin filament; intermediate filament; intercellular junction; Z disc; nucleus; sarcolemma
Molecular Function: protein binding; protein complex binding; structural molecule activity
Biological Process: viral reproduction; tumor necrosis factor-mediated signaling pathway; response to other organism; sarcomere organization; response to hydrostatic pressure
Disease: Cirrhosis, Familial
Reference #:  P05787 (UniProtKB)
Alt. Names/Synonyms: CARD2; CK-8; CK8; CYK8; cytokeratin 8; Cytokeratin-8; K2C8; K8; keratin 8; Keratin, type II cytoskeletal 8; Keratin-8; KO; KRT8; Type-II keratin Kb8
Gene Symbols: KRT8
Molecular weight: 53,704 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

K8

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S74‑p, S432‑p
cytoskeletal reorganization: S74‑p, S432‑p
intracellular localization: S74‑p, S432‑p
molecular association, regulation: S74‑p
protein conformation: S291‑p
protein stabilization: S74‑p
ubiquitination: S74‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S2-p ______MsIRVtQks
0 1 T6-p __MsIRVtQksykVs
0 1 K8-ac MsIRVtQksykVsTs
0 2 K8-ub MsIRVtQksykVsTs
2 24 S9-p sIRVtQksykVsTsG
0 2 Y10-p IRVtQksykVsTsGP
2 1 K11-ac RVtQksykVsTsGPr
0 6 K11-ub RVtQksykVsTsGPr
1 5 S13-p tQksykVsTsGPrAF
0 1 S13-gl tQksykVsTsGPrAF
0 1 T14 QksykVsTsGPrAFs
0 1 S15-gl ksykVsTsGPrAFss
0 2 S15-p ksykVsTsGPrAFss
0 1 R18-m2 kVsTsGPrAFssrsy
0 1 R18-m1 kVsTsGPrAFssrsy
0 44 S21-p TsGPrAFssrsytsG
0 25 S22-p sGPrAFssrsytsGP
0 5 R23-m1 GPrAFssrsytsGPG
5 114 S24-p PrAFssrsytsGPGs
0 85 Y25-p rAFssrsytsGPGsr
0 24 T26-p AFssrsytsGPGsrI
0 33 S27-p FssrsytsGPGsrIs
0 19 S31-p sytsGPGsrIssssF
0 7 R32-m1 ytsGPGsrIssssFs
1 48 S34-p sGPGsrIssssFsrV
0 102 S35-p GPGsrIssssFsrVG
0 11 S36-p PGsrIssssFsrVGs
1 27 S37-p GsrIssssFsrVGss
0 23 S39-p rIssssFsrVGssNF
0 1 R40-m1 IssssFsrVGssNFr
1 74 S43-p ssFsrVGssNFrGGL
0 21 S44-p sFsrVGssNFrGGLG
0 2 - gap
0 5 - gap
1 5 - gap
0 9 R47-m1 rVGssNFrGGLGGGy
0 3 R47-m2 rVGssNFrGGLGGGy
1 2 G49 GssNFrGGLGGGyGG
0 1 Y54-p rGGLGGGyGGAsGMG
0 1 S58-p GGGyGGAsGMGGItA
0 1 T64-p AsGMGGItAVtVNQs
0 2 T67-p MGGItAVtVNQsLLs
0 1 S71-p tAVtVNQsLLsPLVL
25 12 S74-p tVNQsLLsPLVLEVD
0 1 V77 QsLLsPLVLEVDPNI
0 1 T89-p PNIQAVRtQEkEQIk
0 2 K92 QAVRtQEKEQIkTLN
0 2 K92-ub QAVRtQEkEQIkTLN
0 6 K96-ub tQEkEQIkTLNNkFA
1 32 K101-ac QIkTLNNkFAsFIDk
0 9 K101-ub QIkTLNNkFAsFIDk
0 1 K101 QIkTLNNKFAsFIDk
0 23 S104-p TLNNkFAsFIDkVRF
0 7 K108-ac kFAsFIDkVRFLEQQ
0 10 K108-ub kFAsFIDkVRFLEQQ
0 4 K117-ac RFLEQQNkMLETkWs
0 9 K117-ub RFLEQQNkMLETkWs
0 6 K122-ac QNkMLETkWsLLQQQ
0 7 K122-ub QNkMLETkWsLLQQQ
0 1 S124-p kMLETkWsLLQQQkt
0 1 K130-ac WsLLQQQktARsNMD
0 10 K130-ub WsLLQQQktARsNMD
0 1 T131-p sLLQQQktARsNMDN
0 1 S134-p QQQktARsNMDNMFE
0 5 S142-p NMDNMFEsyINNLRR
0 8 Y143-p MDNMFEsyINNLRRQ
0 2 K158-ub LETLGQEkLkLEAEL
0 1 K160-ub TLGQEkLkLEAELGN
0 1 K176-ub QGLVEDFkNkYEDEI
0 3 K178-ac LVEDFkNkYEDEINK
0 1 T187-p EDEINKRtEMENEFV
0 2 K197-ub ENEFVLIkkDVDEAy
0 1 K198 NEFVLIkKDVDEAyM
0 2 K198-ub NEFVLIkkDVDEAyM
1 117 Y204-p kkDVDEAyMNkVELE
1 4 K207-ac VDEAyMNkVELEsRL
0 3 K207-ub VDEAyMNkVELEsRL
0 2 S212-p MNkVELEsRLEGLtD
0 1 T218-p EsRLEGLtDEINFLR
0 1 Y228-p INFLRQLyEEEIREL
0 3 S247-p SDTSVVLsMDNSRsL
0 19 S253-p LsMDNSRsLDMDsII
0 12 S258-p SRsLDMDsIIAEVkA
0 6 K264-ub DsIIAEVkAQyEDIA
1 441 Y267-p IAEVkAQyEDIANRs
0 9 S274-p yEDIANRsRAEAEsM
0 8 S280-p RsRAEAEsMyQIkyE
0 106 Y282-p RAEAEsMyQIkyEEL
0 5 K285-ac AEsMyQIkyEELQsL
1 0 K285-sm AEsMyQIkyEELQsL
0 5 K285-ub AEsMyQIkyEELQsL
0 49 Y286-p EsMyQIkyEELQsLA
1 6 S291-p IkyEELQsLAGkHGD
0 4 K295-ac ELQsLAGkHGDDLRR
0 3 K295-ub ELQsLAGkHGDDLRR
0 2 T303-p HGDDLRRtktEIsEM
0 1 K304 GDDLRRtKtEIsEMN
0 8 K304-ub GDDLRRtktEIsEMN
0 31 T305-p DDLRRtktEIsEMNR
0 1 S308-p RRtktEIsEMNRNIs
0 5 S315-p sEMNRNIsRLQAEIE
0 4 K325-ac QAEIEGLkGQRAsLE
0 22 K325-ub QAEIEGLkGQRAsLE
0 1 K325 QAEIEGLKGQRAsLE
0 10 S330-p GLkGQRAsLEAAIAD
0 3 K347-ac QRGELAIkDANAkLs
0 7 K347-ub QRGELAIkDANAkLs
0 1 K347 QRGELAIKDANAkLs
0 2 K352-ac AIkDANAkLsELEAA
0 5 K352-ub AIkDANAkLsELEAA
0 3 S354-p kDANAkLsELEAALQ
0 1 E357 NAkLsELEAALQRAk
1 0 K364-sm EAALQRAkQDMARQL
1 2 K393-ac IEIATYRkLLEGEEs
0 59 K393-ub IEIATYRkLLEGEEs
0 3 S400-p kLLEGEEsRLEsGMQ
0 3 S404-p GEEsRLEsGMQNMsI
0 8 S410-p EsGMQNMsIHtKtts
0 1 T413-p MQNMsIHtKttsGyA
0 1 T415-p NMsIHtKttsGyAGG
0 2 T416-p MsIHtKttsGyAGGL
1 2 S417-p sIHtKttsGyAGGLs
0 6 Y419-p HtKttsGyAGGLssA
0 2 S424-p sGyAGGLssAyGGLt
0 2 S425-p GyAGGLssAyGGLts
1 0 A426 yAGGLssAyGGLtsP
0 19 Y427-p AGGLssAyGGLtsPG
1 1 T431-p ssAyGGLtsPGLsys
20 27 S432-p sAyGGLtsPGLsysL
0 7 S436-p GLtsPGLsysLGssF
0 49 Y437-p LtsPGLsysLGssFG
0 3 S438-p tsPGLsysLGssFGs
0 4 S441-p GLsysLGssFGsGAG
0 8 S442-p LsysLGssFGsGAGs
0 8 S445-p sLGssFGsGAGsssF
0 1 S449-p sFGsGAGsssFsRts
0 1 S450-p FGsGAGsssFsRtss
0 4 S451-p GsGAGsssFsRtsss
0 1 S453-p GAGsssFsRtsssRA
0 7 T455-p GsssFsRtsssRAVV
0 9 S456-p sssFsRtsssRAVVV
0 17 S457-p ssFsRtsssRAVVVk
0 2 S458-p sFsRtsssRAVVVkk
0 4 K464-ac ssRAVVVkkIETRDG
0 3 K465-ac sRAVVVkkIETRDGk
2 5 K472-ac kIETRDGkLVsEssD
0 11 K472-ub kIETRDGkLVsEssD
0 20 S475-p TRDGkLVsEssDVLP
0 1 S475-gl TRDGkLVsEssDVLP
0 2 S477-p DGkLVsEssDVLPk_
0 11 S478-p GkLVsEssDVLPk__
0 7 P482 sEssDVLPk______
3 38 K483-ac EssDVLPk_______
0 3 K483 EssDVLPK_______
  K8 iso2  
S30 STPASTMSIRVTQKS
T34 STMSIRVTQKSYKVS
K36 MSIRVTQKSYKVSTS
K36 MSIRVTQKSYKVSTS
S37 SIRVTQKSYKVSTSG
Y38 IRVTQKSYKVSTSGP
K39 RVTQKSYKVSTSGPR
K39 RVTQKSYKVSTSGPR
S41 TQKSYKVSTSGPRAF
S41 TQKSYKVSTSGPRAF
T42 QKSYKVSTSGPRAFS
S43 KSYKVSTSGPRAFSS
S43 KSYKVSTSGPRAFSS
R46 KVSTSGPRAFSSRSY
R46 KVSTSGPRAFSSRSY
S49 TSGPRAFSSRSYTSG
S50 SGPRAFSSRSYTSGP
R51 GPRAFSSRSYTSGPG
S52 PRAFSSRSYTSGPGS
Y53 RAFSSRSYTSGPGSR
T54 AFSSRSYTSGPGSRI
S55 FSSRSYTSGPGSRIS
S59 SYTSGPGSRISSSSF
R60 YTSGPGSRISSSSFS
S62 SGPGSRISSSSFSRV
S63 GPGSRISSSSFSRVG
S64 PGSRISSSSFSRVGS
S65 GSRISSSSFSRVGSS
S67 RISSSSFSRVGSSNF
R68 ISSSSFSRVGSSNFR
S71 SSFSRVGSSNFRGGL
S72 SFSRVGSSNFRGGLG
- under review  
- under review  
- under review  
R75 RVGSSNFRGGLGGGY
R75 RVGSSNFRGGLGGGY
G77 GSSNFRGGLGGGYGG
Y82 RGGLGGGYGGASGMG
S86 GGGYGGASGMGGITA
T92 ASGMGGITAVTVNQS
T95 MGGITAVTVNQSLLS
S99 TAVTVNQSLLSPLVL
S102 TVNQSLLSPLVLEVD
V105 QSLLSPLVLEVDPNI
T117 PNIQAVRTQEKEQIK
K120 QAVRTQEKEQIKTLN
K120 QAVRTQEKEQIKTLN
K124 TQEKEQIKTLNNKFA
K129 QIKTLNNKFASFIDK
K129 QIKTLNNKFASFIDK
K129 QIKTLNNKFASFIDK
S132 TLNNKFASFIDKVRF
K136 KFASFIDKVRFLEQQ
K136 KFASFIDKVRFLEQQ
K145 RFLEQQNKMLETKWS
K145 RFLEQQNKMLETKWS
K150 QNKMLETKWSLLQQQ
K150 QNKMLETKWSLLQQQ
S152 KMLETKWSLLQQQKT
K158 WSLLQQQKTARSNMD
K158 WSLLQQQKTARSNMD
T159 SLLQQQKTARSNMDN
S162 QQQKTARSNMDNMFE
S170 NMDNMFESYINNLRR
Y171 MDNMFESYINNLRRQ
K186 LETLGQEKLKLEAEL
K188 TLGQEKLKLEAELGN
K204 QGLVEDFKNKYEDEI
K206 LVEDFKNKYEDEINK
T215 EDEINKRTEMENEFV
K225 ENEFVLIKKDVDEAY
K226 NEFVLIKKDVDEAYM
K226 NEFVLIKKDVDEAYM
Y232 KKDVDEAYMNKVELE
K235 VDEAYMNKVELESRL
K235 VDEAYMNKVELESRL
S240 MNKVELESRLEGLTD
T246 ESRLEGLTDEINFLR
Y256 INFLRQLYEEEIREL
S275 SDTSVVLSMDNSRSL
S281 LSMDNSRSLDMDSII
S286 SRSLDMDSIIAEVKA
K292 DSIIAEVKAQYEDIA
Y295 IAEVKAQYEDIANRS
S302 YEDIANRSRAEAESM
S308 RSRAEAESMYQIKYE
Y310 RAEAESMYQIKYEEL
K313 AESMYQIKYEELQSL
K313 AESMYQIKYEELQSL
K313 AESMYQIKYEELQSL
Y314 ESMYQIKYEELQSLA
S319 IKYEELQSLAGKHGD
K323 ELQSLAGKHGDDLRR
K323 ELQSLAGKHGDDLRR
T331 HGDDLRRTKTEISEM
K332 GDDLRRTKTEISEMN
K332 GDDLRRTKTEISEMN
T333 DDLRRTKTEISEMNR
S336 RRTKTEISEMNRNIS
S343 SEMNRNISRLQAEIE
K353 QAEIEGLKGQRASLE
K353 QAEIEGLKGQRASLE
K353 QAEIEGLKGQRASLE
S358 GLKGQRASLEAAIAD
K375 QRGELAIKDANAKLS
K375 QRGELAIKDANAKLS
K375 QRGELAIKDANAKLS
K380 AIKDANAKLSELEAA
K380 AIKDANAKLSELEAA
S382 KDANAKLSELEAALQ
E385 NAKLSELEAALQRAK
K392 EAALQRAKQDMARQL
K421 IEIATYRKLLEGEES
K421 IEIATYRKLLEGEES
S428 KLLEGEESRLESGMQ
S432 GEESRLESGMQNMSI
S438 ESGMQNMSIHTKTTS
T441 MQNMSIHTKTTSGYA
T443 NMSIHTKTTSGYAGG
T444 MSIHTKTTSGYAGGL
S445 SIHTKTTSGYAGGLS
Y447 HTKTTSGYAGGLSSA
S452 SGYAGGLSSAYGGLT
S453 GYAGGLSSAYGGLTS
A454 YAGGLSSAYGGLTSP
Y455 AGGLSSAYGGLTSPG
T459 SSAYGGLTSPGLSYS
S460 SAYGGLTSPGLSYSL
S464 GLTSPGLSYSLGSSF
Y465 LTSPGLSYSLGSSFG
S466 TSPGLSYSLGSSFGS
S469 GLSYSLGSSFGSGAG
S470 LSYSLGSSFGSGAGS
S473 SLGSSFGSGAGSSSF
S477 SFGSGAGSSSFSRTS
S478 FGSGAGSSSFSRTSS
S479 GSGAGSSSFSRTSSS
S481 GAGSSSFSRTSSSRA
T483 GSSSFSRTSSSRAVV
S484 SSSFSRTSSSRAVVV
S485 SSFSRTSSSRAVVVK
S486 SFSRTSSSRAVVVKK
K492 SSRAVVVKKIETRDG
K493 SRAVVVKKIETRDGK
K500 KIETRDGKLVSESSD
K500 KIETRDGKLVSESSD
S503 TRDGKLVSESSDVLP
S503 TRDGKLVSESSDVLP
S505 DGKLVSESSDVLPK_
S506 GKLVSESSDVLPK__
P510 SESSDVLPK______
K511 ESSDVLPK_______
K511 ESSDVLPK_______
  mouse

 
S2 ______MSIRVTQKs
T6 __MSIRVTQKsYkMs
K8 MSIRVTQKsYkMsts
K8 MSIRVTQKsYkMsts
S9-p SIRVTQKsYkMstsG
Y10 IRVTQKsYkMstsGP
K11 RVTQKsYKMstsGPr
K11-ub RVTQKsYkMstsGPr
S13-p TQKsYkMstsGPrAF
S13 TQKsYkMStsGPrAF
T14-p QKsYkMstsGPrAFs
S15 KsYkMstSGPrAFss
S15-p KsYkMstsGPrAFss
R18 kMstsGPRAFssRsF
R18-m1 kMstsGPrAFssRsF
S21-p tsGPrAFssRsFtsG
S22-p sGPrAFssRsFtsGP
R23 GPrAFssRsFtsGPG
S24-p PrAFssRsFtsGPGA
F25 rAFssRsFtsGPGAR
T26-p AFssRsFtsGPGARI
S27-p FssRsFtsGPGARIs
A31 sFtsGPGARIssssF
R32 FtsGPGARIssssFs
S34-p sGPGARIssssFsRV
S35-p GPGARIssssFsRVG
S36-p PGARIssssFsRVGs
S37-p GARIssssFsRVGss
S39-p RIssssFsRVGssss
R40 IssssFsRVGsssss
S43-p ssFsRVGsssssFRG
S44-p sFsRVGsssssFRGS
S45-p FsRVGsssssFRGSM
S46-p sRVGsssssFRGSMG
S47-p RVGsssssFRGSMGT
R49 GsssssFRGSMGTGV
R49 GsssssFRGSMGTGV
S51 ssssFRGSMGTGVGL
F61 TGVGLGGFGGAGVGG
G65 LGGFGGAGVGGITAV
T70 GAGVGGITAVTVNQS
T73 VGGITAVTVNQSLLs
S77 TAVTVNQSLLsPLkL
S80-p TVNQSLLsPLkLEVD
K83-ub QSLLsPLkLEVDPNI
T95 PNIQAVRTQEkEQIK
K98-ac QAVRTQEkEQIKSLN
K98 QAVRTQEKEQIKSLN
K102 TQEkEQIKSLNNkFA
K107-ac QIKSLNNkFAsFIDk
K107-ub QIKSLNNkFAsFIDk
K107-sc QIKSLNNkFAsFIDk
S110-p SLNNkFAsFIDkVRF
K114 kFAsFIDKVRFLEQQ
K114-ub kFAsFIDkVRFLEQQ
K123 RFLEQQNKMLETkWS
K123-ub RFLEQQNkMLETkWS
K128-ac QNkMLETkWSLLQQQ
K128-ub QNkMLETkWSLLQQQ
S130 kMLETkWSLLQQQkT
K136 WSLLQQQKTSRSNMD
K136-ub WSLLQQQkTSRSNMD
T137 SLLQQQkTSRSNMDN
S140 QQQkTSRSNMDNMFE
S148 NMDNMFESYINNLRR
Y149 MDNMFESYINNLRRQ
K164-ub LEALGQEkLKLEAEL
K166 ALGQEkLKLEAELGN
K182 QGLVEDFKNkYEDEI
K184-ac LVEDFKNkYEDEINK
T193 EDEINKRTEMENEFV
K203-ub ENEFVLIkkDVDEAy
K204 NEFVLIkKDVDEAyM
K204-ub NEFVLIkkDVDEAyM
Y210-p kkDVDEAyMNkVELE
K213 VDEAyMNKVELESRL
K213-ub VDEAyMNkVELESRL
S218 MNkVELESRLEGLTD
T224 ESRLEGLTDEINFLR
H234 INFLRQIHEEEIREL
S253-p SDTSVVLsMDNSRsL
S259-p LsMDNSRsLDMDGII
G264 SRsLDMDGIIAEVRA
R270 DGIIAEVRAQyEDIA
Y273-p IAEVRAQyEDIANRS
S280 yEDIANRSRAEAETM
T286 RSRAEAETMYQIKYE
Y288 RAEAETMYQIKYEEL
K291 AETMYQIKYEELQTL
K291 AETMYQIKYEELQTL
K291 AETMYQIKYEELQTL
Y292 ETMYQIKYEELQTLA
T297 IKYEELQTLAGkHGD
K301 ELQTLAGKHGDDLRR
K301-ub ELQTLAGkHGDDLRR
T309 HGDDLRRTktEISEM
K310 GDDLRRTKtEISEMN
K310-ub GDDLRRTktEISEMN
T311-p DDLRRTktEISEMNR
S314 RRTktEISEMNRNIN
N321 SEMNRNINRLQAEIE
K331-ac QAEIEALkGQRAsLE
K331-ub QAEIEALkGQRAsLE
K331-sc QAEIEALkGQRAsLE
S336-p ALkGQRAsLEAAIAD
K353 QRGEMAIKDAQTKLA
K353-ub QRGEMAIkDAQTKLA
K353-sc QRGEMAIkDAQTKLA
K358 AIkDAQTKLAELEAA
K358 AIkDAQTKLAELEAA
A360 kDAQTKLAELEAALQ
E363 QTKLAELEAALQRAK
K370 EAALQRAKQDMARQL
K399 IEITTYRKLLEGEES
K399-ub IEITTYRkLLEGEES
S406 kLLEGEESRLESGMQ
S410 GEESRLESGMQNMsI
S416-p ESGMQNMsIHTKTTS
T419 MQNMsIHTKTTSGYS
T421 NMsIHTKTTSGYSGG
T422 MsIHTKTTSGYSGGL
S423 sIHTKTTSGYSGGLS
Y425 HTKTTSGYSGGLSSS
S430 SGYSGGLSSSYGGLT
S431 GYSGGLSSSYGGLTs
S432 YSGGLSSSYGGLTsP
Y433 SGGLSSSYGGLTsPG
T437 SSSYGGLTsPGFSYG
S438-p SSYGGLTsPGFSYGM
S442 GLTsPGFSYGMSSFQ
Y443 LTsPGFSYGMSSFQP
S447 GFSYGMSSFQPGFGS
P450 YGMSSFQPGFGSAGG
G451 GMSSFQPGFGSAGGS
S454 SFQPGFGSAGGSNTF
S458 GFGSAGGSNTFSRTT
N459 FGSAGGSNTFSRTTK
T460 GSAGGSNTFSRTTKA
S462 AGGSNTFSRTTKAVV
T464 GSNTFSRTTKAVVVK
- gap
- gap
T465 SNTFSRTTKAVVVKK
K471 TTKAVVVKKIETRDG
K472 TKAVVVKKIETRDGk
K479-ac KIETRDGkLVsESsD
K479-ub KIETRDGkLVsESsD
S482-p TRDGkLVsESsDVVs
S482 TRDGkLVSESsDVVs
S484 DGkLVsESsDVVsk_
S485-p GkLVsESsDVVsk__
S489-p sESsDVVsk______
K490-ac ESsDVVsk_______
K490-ub ESsDVVsk_______
  rat

 
S2-p ______MsVRVTQKs
T6 __MsVRVTQKsYKMs
K8 MsVRVTQKsYKMsTS
K8 MsVRVTQKsYKMsTS
S9-p sVRVTQKsYKMsTSG
Y10 VRVTQKsYKMsTSGP
K11 RVTQKsYKMsTSGPR
K11 RVTQKsYKMsTSGPR
S13-p TQKsYKMsTSGPRAF
S13 TQKsYKMSTSGPRAF
T14 QKsYKMsTSGPRAFs
S15 KsYKMsTSGPRAFss
S15 KsYKMsTSGPRAFss
R18 KMsTSGPRAFssRsF
R18 KMsTSGPRAFssRsF
S21-p TSGPRAFssRsFtsG
S22-p SGPRAFssRsFtsGP
R23 GPRAFssRsFtsGPG
S24-p PRAFssRsFtsGPGA
F25 RAFssRsFtsGPGAR
T26-p AFssRsFtsGPGARI
S27-p FssRsFtsGPGARIs
A31 sFtsGPGARIsSSsF
R32 FtsGPGARIsSSsFs
S34-p sGPGARIsSSsFsRV
S35 GPGARIsSSsFsRVG
S36 PGARIsSSsFsRVGs
S37-p GARIsSSsFsRVGss
S39-p RIsSSsFsRVGssss
R40 IsSSsFsRVGsssss
S43-p SsFsRVGsssssFRG
S44-p sFsRVGsssssFRGs
S45-p FsRVGsssssFRGsL
S46-p sRVGsssssFRGsLG
S47-p RVGsssssFRGsLGG
R49 GsssssFRGsLGGFG
R49 GsssssFRGsLGGFG
S51-p ssssFRGsLGGFGGA
F55 FRGsLGGFGGAGVGG
G59 LGGFGGAGVGGITAV
T64 GAGVGGITAVTVNQS
T67 VGGITAVTVNQSLLN
S71 TAVTVNQSLLNPLKL
N74 TVNQSLLNPLKLEVD
K77 QSLLNPLKLEVDPNI
T89 PNIQAVRTQEKEQIK
K92 QAVRTQEKEQIKTLN
K92 QAVRTQEKEQIKTLN
K96 TQEKEQIKTLNNkFA
K101-ac QIKTLNNkFAsFIDk
K101 QIKTLNNKFAsFIDk
K101 QIKTLNNKFAsFIDk
S104-p TLNNkFAsFIDkVRF
K108-ac kFAsFIDkVRFLEQQ
K108 kFAsFIDKVRFLEQQ
K117-ac RFLEQQNkMLETkWS
K117 RFLEQQNKMLETkWS
K122-ac QNkMLETkWSLLQQQ
K122 QNkMLETKWSLLQQQ
S124 kMLETkWSLLQQQKT
K130 WSLLQQQKTSRSNMD
K130 WSLLQQQKTSRSNMD
T131 SLLQQQKTSRSNMDN
S134 QQQKTSRSNMDNMFE
S142 NMDNMFESYINNLRR
Y143 MDNMFESYINNLRRQ
K158 LEALGQEKLKLEVEL
K160 ALGQEKLKLEVELGN
K176 QGLVEDFKNkYEDEI
K178-ac LVEDFKNkYEDEINK
T187 EDEINKRTEMENEFV
K197 ENEFVLIKkDVDEAY
K198-ac NEFVLIKkDVDEAYM
K198 NEFVLIKKDVDEAYM
Y204 KkDVDEAYMNkVELE
K207-ac VDEAYMNkVELESRL
K207 VDEAYMNKVELESRL
S212 MNkVELESRLEGLTD
T218 ESRLEGLTDEINFLR
H228 INFLRQIHEEEIREL
S247 SDTSVVLSMDNSRsL
S253-p LSMDNSRsLDMDsII
S258-p SRsLDMDsIIAEVRA
R264 DsIIAEVRAQYEEIA
Y267 IAEVRAQYEEIANRS
S274 YEEIANRSRAEAETM
T280 RSRAEAETMYQIkYE
Y282 RAEAETMYQIkYEEL
K285-ac AETMYQIkYEELQTL
K285 AETMYQIKYEELQTL
K285 AETMYQIKYEELQTL
Y286 ETMYQIkYEELQTLA
T291 IkYEELQTLAGkHGD
K295-ac ELQTLAGkHGDDLRR
K295 ELQTLAGKHGDDLRR
S303 HGDDLRRSkTEISEM
K304-ac GDDLRRSkTEISEMN
K304 GDDLRRSKTEISEMN
T305 DDLRRSkTEISEMNR
S308 RRSkTEISEMNRNIS
S315 SEMNRNISRLQAEID
K325-ac QAEIDALkGQRATLE
K325 QAEIDALKGQRATLE
K325 QAEIDALKGQRATLE
T330 ALkGQRATLEAAIAD
K347-ac QRGELAVkDANAkLE
K347 QRGELAVKDANAkLE
K347 QRGELAVKDANAkLE
K352-ac AVkDANAkLEDLkNA
K352 AVkDANAKLEDLkNA
E354 kDANAkLEDLkNALQ
K357-ac NAkLEDLkNALQKAK
K364 kNALQKAKQDMARQL
K393-ac IEIATYRkLLEGEES
K393 IEIATYRKLLEGEES
S400 kLLEGEESRLESGMQ
S404 GEESRLESGMQNMSI
S410 ESGMQNMSIHTKTTs
T413 MQNMSIHTKTTsGYA
T415 NMSIHTKTTsGYAGG
T416 MSIHTKTTsGYAGGL
S417-p SIHTKTTsGYAGGLS
Y419 HTKTTsGYAGGLSSs
S424 sGYAGGLSSsYGGLT
S425 GYAGGLSSsYGGLTs
S426-p YAGGLSSsYGGLTsP
Y427 AGGLSSsYGGLTsPG
T431 SSsYGGLTsPGFSYG
S432-p SsYGGLTsPGFSYGM
S436 GLTsPGFSYGMSSFQ
Y437 LTsPGFSYGMSSFQP
S441 GFSYGMSSFQPGFGS
P444 YGMSSFQPGFGSVGG
G445 GMSSFQPGFGSVGGS
S448 SFQPGFGSVGGSSTY
S452 GFGSVGGSSTYSRTK
S453 FGSVGGSSTYSRTKA
T454 GSVGGSSTYSRTKAV
S456 VGGSSTYSRTKAVVV
T458 GSSTYSRTKAVVVkK
- gap
- gap
- gap
K464-ac RTKAVVVkKIETRDG
K465 TKAVVVkKIETRDGk
K472-ac KIETRDGkLVsEssD
K472 KIETRDGKLVsEssD
S475-p TRDGkLVsEssDIMs
S475 TRDGkLVSEssDIMs
S477-p DGkLVsEssDIMsK_
S478-p GkLVsEssDIMsK__
S482-p sEssDIMsK______
K483 EssDIMsK_______
K483 EssDIMsK_______
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