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K8 (human)

Overview K8 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Phsophorylated by p38 kinase, regulating cellular keratin filament reorganization. Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Mutation of this protein is a risk factor for cryptogenic liver failure. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: nucleoplasm; nuclear matrix; keratin filament; cytoplasm; intermediate filament Molecular Function: protein binding; structural molecule activity Biological Process: virus-host interaction; cytoskeleton organization and biogenesis Reference #:  P05787 (UniProtKB) Alt. Names/Synonyms: CARD2; CK-8; CK8; CYK8; cytokeratin 8; Cytokeratin-8; K2C8; K8; keratin 8; Keratin, type II cytoskeletal 8; Keratin-8; KO; KRT8; Type-II keratin Kb8 Gene Symbols: KRT8 Molecular weight: 53,704 Da Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below K8

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 148060 215600  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell motility, altered: S74‑p, S432‑p cytoskeletal reorganization: S74‑p, S432‑p intracellular localization: S74‑p, S432‑p molecular association, regulation: S74‑p protein conformation: S291‑p protein stabilization: S74‑p ubiquitination: S74‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S2-p	______MsIRVtQks
0	1		T6-p	__MsIRVtQksykVs
0	1		K8-a	MsIRVtQksykVsTs
0	2		K8-u	MsIRVtQksykVsTs
2	23		S9-p	sIRVtQksykVsTsG
0	1		Y10-p	IRVtQksykVsTsGP
2	1		K11-a	RVtQksykVsTsGPr
0	6		K11-u	RVtQksykVsTsGPr
1	3		S13-p	tQksykVsTsGPrAF
0	1		S13-gl	tQksykVsTsGPrAF
0	1		T14	QksykVsTsGPrAFs
0	1		S15-gl	ksykVsTsGPrAFss
0	1		S15	ksykVsTSGPrAFss
0	1		R18-m2	kVsTsGPrAFssrsy
0	36		S21-p	TsGPrAFssrsytsG
0	20		S22-p	sGPrAFssrsytsGP
0	4		R23-m1	GPrAFssrsytsGPG
5	96		S24-p	PrAFssrsytsGPGs
0	78		Y25-p	rAFssrsytsGPGsr
0	21		T26-p	AFssrsytsGPGsrI
0	30		S27-p	FssrsytsGPGsrIs
0	15		S31-p	sytsGPGsrIssssF
0	6		R32-m1	ytsGPGsrIssssFs
1	41		S34-p	sGPGsrIssssFsRV
0	99		S35-p	GPGsrIssssFsRVG
0	10		S36-p	PGsrIssssFsRVGs
1	19		S37-p	GsrIssssFsRVGss
0	18		S39-p	rIssssFsRVGssNF
1	68		S43-p	ssFsRVGssNFrGGL
0	15		S44-p	sFsRVGssNFrGGLG
0	1		-	gap
0	4		-	gap
1	3		-	gap
0	8		R47-m1	RVGssNFrGGLGGGY
0	2		R47-m2	RVGssNFrGGLGGGY
1	1		G49	GssNFrGGLGGGYGG
0	1		T64-p	ASGMGGItAVtVNQS
0	1		T67-p	MGGItAVtVNQSLLs
25	10		S74-p	tVNQSLLsPLVLEVD
0	1		V77	QSLLsPLVLEVDPNI
0	1		T89-p	PNIQAVRtQEkEQIk
0	2		K92	QAVRtQEKEQIkTLN
0	2		K92-u	QAVRtQEkEQIkTLN
0	6		K96-u	tQEkEQIkTLNNkFA
2	30		K101-a	QIkTLNNkFAsFIDk
0	9		K101-u	QIkTLNNkFAsFIDk
0	15		S104-p	TLNNkFAsFIDkVRF
0	6		K108-a	kFAsFIDkVRFLEQQ
0	10		K108-u	kFAsFIDkVRFLEQQ
0	2		K117-a	RFLEQQNkMLETkWS
0	9		K117-u	RFLEQQNkMLETkWS
0	5		K122-a	QNkMLETkWSLLQQQ
0	7		K122-u	QNkMLETkWSLLQQQ
0	10		K130-u	WSLLQQQkTARSNMD
0	1		S142-p	NMDNMFEsyINNLRR
0	7		Y143-p	MDNMFEsyINNLRRQ
0	2		K158-u	LETLGQEkLkLEAEL
0	1		K160-u	TLGQEkLkLEAELGN
0	1		K176-u	QGLVEDFkNKyEDEI
0	2		K178	LVEDFkNKyEDEINK
0	3		Y179-p	VEDFkNKyEDEINKR
0	1		T187-p	EDEINKRtEMENEFV
0	2		K197-u	ENEFVLIkkDVDEAy
0	2		K198-u	NEFVLIkkDVDEAyM
0	104		Y204-p	kkDVDEAyMNkVELE
1	2		K207-a	VDEAyMNkVELEsRL
0	3		K207-u	VDEAyMNkVELEsRL
0	1		S212-p	MNkVELEsRLEGLTD
0	1		Y228-p	INFLRQLyEEEIREL
0	11		S253-p	LSMDNSRsLDMDsII
0	5		S258-p	SRsLDMDsIIAEVkA
0	6		K264-u	DsIIAEVkAQyEDIA
0	433		Y267-p	IAEVkAQyEDIANRs
0	6		S274-p	yEDIANRsRAEAEsM
0	6		S280-p	RsRAEAEsMyQIkyE
0	101		Y282-p	RAEAEsMyQIkyEEL
0	3		K285-a	AEsMyQIkyEELQsL
1	0		K285-s	AEsMyQIkyEELQsL
0	5		K285-u	AEsMyQIkyEELQsL
0	38		Y286-p	EsMyQIkyEELQsLA
1	2		S291-p	IkyEELQsLAGkHGD
0	2		K295-a	ELQsLAGkHGDDLRR
0	3		K295-u	ELQsLAGkHGDDLRR
0	2		T303-p	HGDDLRRtktEIsEM
0	8		K304-u	GDDLRRtktEIsEMN
0	31		T305-p	DDLRRtktEIsEMNR
0	1		S308-p	RRtktEIsEMNRNIs
0	3		S315-p	sEMNRNIsRLQAEIE
0	2		K325-a	QAEIEGLkGQRAsLE
0	22		K325-u	QAEIEGLkGQRAsLE
0	3		S330-p	GLkGQRAsLEAAIAD
0	7		K347-u	QRGELAIkDANAkLS
0	5		K352-u	AIkDANAkLSELEAA
1	0		K364-s	EAALQRAkQDMARQL
0	1		Y391-p	LDIEIATyRkLLEGE
1	1		K393-a	IEIATyRkLLEGEEs
0	59		K393-u	IEIATyRkLLEGEEs
0	2		S400-p	kLLEGEEsRLESGMQ
0	2		S410-p	ESGMQNMsIHTKTts
0	1		T416-p	MsIHTKTtsGyAGGL
1	1		S417-p	sIHTKTtsGyAGGLs
0	7		Y419-p	HTKTtsGyAGGLsSA
0	1		S424-p	sGyAGGLsSAyGGLt
1	0		A426	yAGGLsSAyGGLtsP
0	17		Y427-p	AGGLsSAyGGLtsPG
1	1		T431-p	sSAyGGLtsPGLsys
20	21		S432-p	SAyGGLtsPGLsysL
0	6		S436-p	GLtsPGLsysLGssF
0	50		Y437-p	LtsPGLsysLGssFG
0	1		S438-p	tsPGLsysLGssFGs
0	2		S441-p	GLsysLGssFGsGAG
0	7		S442-p	LsysLGssFGsGAGs
0	7		S445-p	sLGssFGsGAGsssF
0	1		S449-p	sFGsGAGsssFsRts
0	1		S450-p	FGsGAGsssFsRtss
0	3		S451-p	GsGAGsssFsRtsss
0	1		S453-p	GAGsssFsRtsssRA
0	7		T455-p	GsssFsRtsssRAVV
0	9		S456-p	sssFsRtsssRAVVV
0	16		S457-p	ssFsRtsssRAVVVk
0	2		S458-p	sFsRtsssRAVVVkk
0	3		K464-a	ssRAVVVkkIETRDG
0	3		K465-a	sRAVVVkkIETRDGk
2	3		K472-a	kIETRDGkLVsESsD
0	11		K472-u	kIETRDGkLVsESsD
0	11		S475-p	TRDGkLVsESsDVLP
0	1		S475-gl	TRDGkLVsESsDVLP
0	1		S477	DGkLVsESsDVLPk_
0	5		S478-p	GkLVsESsDVLPk__
0	3		P482	sESsDVLPk______
3	38		K483-a	ESsDVLPk_______
0	3		K483	ESsDVLPK_______

	mouse
S2	______MSIRVTQKs
T6	__MSIRVTQKsYkMs
K8	MSIRVTQKsYkMsts
K8	MSIRVTQKsYkMsts
S9-p	SIRVTQKsYkMstsG
Y10	IRVTQKsYkMstsGP
K11	RVTQKsYKMstsGPR
K11-u	RVTQKsYkMstsGPR
S13-p	TQKsYkMstsGPRAF
S13	TQKsYkMStsGPRAF
T14-p	QKsYkMstsGPRAFs
S15	KsYkMstSGPRAFss
S15-p	KsYkMstsGPRAFss
R18	kMstsGPRAFssRsF
S21-p	tsGPRAFssRsFtsG
S22-p	sGPRAFssRsFtsGP
R23	GPRAFssRsFtsGPG
S24-p	PRAFssRsFtsGPGA
F25	RAFssRsFtsGPGAR
T26-p	AFssRsFtsGPGARI
S27-p	FssRsFtsGPGARIs
A31	sFtsGPGARIssssF
R32	FtsGPGARIssssFs
S34-p	sGPGARIssssFsRV
S35-p	GPGARIssssFsRVG
S36-p	PGARIssssFsRVGs
S37-p	GARIssssFsRVGss
S39-p	RIssssFsRVGssSs
S43-p	ssFsRVGssSssFRG
S44-p	sFsRVGssSssFRGS
S45	FsRVGssSssFRGSM
S46-p	sRVGssSssFRGSMG
S47-p	RVGssSssFRGSMGT
R49	GssSssFRGSMGTGV
R49	GssSssFRGSMGTGV
S51	sSssFRGSMGTGVGL
T70	GAGVGGITAVTVNQS
T73	VGGITAVTVNQSLLs
S80-p	TVNQSLLsPLkLEVD
K83-u	QSLLsPLkLEVDPNI
T95	PNIQAVRTQEkEQIK
K98-a	QAVRTQEkEQIKSLN
K98	QAVRTQEKEQIKSLN
K102	TQEkEQIKSLNNkFA
K107-a	QIKSLNNkFAsFIDk
K107-u	QIKSLNNkFAsFIDk
S110-p	SLNNkFAsFIDkVRF
K114	kFAsFIDKVRFLEQQ
K114-u	kFAsFIDkVRFLEQQ
K123	RFLEQQNKMLETkWS
K123-u	RFLEQQNkMLETkWS
K128-a	QNkMLETkWSLLQQQ
K128-u	QNkMLETkWSLLQQQ
K136-u	WSLLQQQkTSRSNMD
S148	NMDNMFESYINNLRR
Y149	MDNMFESYINNLRRQ
K164-u	LEALGQEkLKLEAEL
K166	ALGQEkLKLEAELGN
K182	QGLVEDFKNkYEDEI
K184-a	LVEDFKNkYEDEINK
Y185	VEDFKNkYEDEINKR
T193	EDEINKRTEMENEFV
K203-u	ENEFVLIkkDVDEAy
K204-u	NEFVLIkkDVDEAyM
Y210-p	kkDVDEAyMNkVELE
K213	VDEAyMNKVELESRL
K213-u	VDEAyMNkVELESRL
S218	MNkVELESRLEGLTD
H234	INFLRQIHEEEIREL
S259-p	LSMDNSRsLDMDGII
G264	SRsLDMDGIIAEVRA
R270	DGIIAEVRAQyEDIA
Y273-p	IAEVRAQyEDIANRS
S280	yEDIANRSRAEAETM
T286	RSRAEAETMYQIKYE
Y288	RAEAETMYQIKYEEL
K291	AETMYQIKYEELQTL
K291	AETMYQIKYEELQTL
K291	AETMYQIKYEELQTL
Y292	ETMYQIKYEELQTLA
T297	IKYEELQTLAGkHGD
K301	ELQTLAGKHGDDLRR
K301-u	ELQTLAGkHGDDLRR
T309	HGDDLRRTktEISEM
K310-u	GDDLRRTktEISEMN
T311-p	DDLRRTktEISEMNR
S314	RRTktEISEMNRNIN
N321	SEMNRNINRLQAEIE
K331-a	QAEIEALkGQRASLE
K331-u	QAEIEALkGQRASLE
S336	ALkGQRASLEAAIAD
K353-u	QRGEMAIkDAQTKLA
K358	AIkDAQTKLAELEAA
K370	EAALQRAKQDMARQL
Y397	LDIEITTYRkLLEGE
K399	IEITTYRKLLEGEES
K399-u	IEITTYRkLLEGEES
S406	kLLEGEESRLESGMQ
S416-p	ESGMQNMsIHTKTTS
T422	MsIHTKTTSGYSGGL
S423	sIHTKTTSGYSGGLS
Y425	HTKTTSGYSGGLSSS
S430	SGYSGGLSSSYGGLT
S432	YSGGLSSSYGGLTsP
Y433	SGGLSSSYGGLTsPG
T437	SSSYGGLTsPGFSYG
S438-p	SSYGGLTsPGFSYGM
S442	GLTsPGFSYGMSSFQ
Y443	LTsPGFSYGMSSFQP
S447	GFSYGMSSFQPGFGS
P450	YGMSSFQPGFGSAGG
G451	GMSSFQPGFGSAGGS
S454	SFQPGFGSAGGSNTF
S458	GFGSAGGSNTFSRTT
N459	FGSAGGSNTFSRTTK
T460	GSAGGSNTFSRTTKA
S462	AGGSNTFSRTTKAVV
T464	GSNTFSRTTKAVVVK
-	gap
-	gap
T465	SNTFSRTTKAVVVKK
K471	TTKAVVVKKIETRDG
K472	TKAVVVKKIETRDGk
K479-a	KIETRDGkLVsESsD
K479-u	KIETRDGkLVsESsD
S482-p	TRDGkLVsESsDVVs
S482	TRDGkLVSESsDVVs
S484	DGkLVsESsDVVsk_
S485-p	GkLVsESsDVVsk__
S489-p	sESsDVVsk______
K490-a	ESsDVVsk_______
K490-u	ESsDVVsk_______

	rat
S2	______MSVRVTQKs
T6	__MSVRVTQKsYKMs
K8	MSVRVTQKsYKMsTS
K8	MSVRVTQKsYKMsTS
S9-p	SVRVTQKsYKMsTSG
Y10	VRVTQKsYKMsTSGP
K11	RVTQKsYKMsTSGPR
K11	RVTQKsYKMsTSGPR
S13-p	TQKsYKMsTSGPRAF
S13	TQKsYKMSTSGPRAF
T14	QKsYKMsTSGPRAFs
S15	KsYKMsTSGPRAFss
S15	KsYKMsTSGPRAFss
R18	KMsTSGPRAFssRsF
S21-p	TSGPRAFssRsFtsG
S22-p	SGPRAFssRsFtsGP
R23	GPRAFssRsFtsGPG
S24-p	PRAFssRsFtsGPGA
F25	RAFssRsFtsGPGAR
T26-p	AFssRsFtsGPGARI
S27-p	FssRsFtsGPGARIs
A31	sFtsGPGARIsSSsF
R32	FtsGPGARIsSSsFS
S34-p	sGPGARIsSSsFSRV
S35	GPGARIsSSsFSRVG
S36	PGARIsSSsFSRVGs
S37-p	GARIsSSsFSRVGss
S39	RIsSSsFSRVGssss
S43-p	SsFSRVGsssssFRG
S44-p	sFSRVGsssssFRGs
S45-p	FSRVGsssssFRGsL
S46-p	SRVGsssssFRGsLG
S47-p	RVGsssssFRGsLGG
R49	GsssssFRGsLGGFG
R49	GsssssFRGsLGGFG
S51-p	ssssFRGsLGGFGGA
T64	GAGVGGITAVTVNQS
T67	VGGITAVTVNQSLLN
N74	TVNQSLLNPLKLEVD
K77	QSLLNPLKLEVDPNI
T89	PNIQAVRTQEKEQIK
K92	QAVRTQEKEQIKTLN
K92	QAVRTQEKEQIKTLN
K96	TQEKEQIKTLNNKFA
K101	QIKTLNNKFASFIDK
K101	QIKTLNNKFASFIDK
S104	TLNNKFASFIDKVRF
K108	KFASFIDKVRFLEQQ
K108	KFASFIDKVRFLEQQ
K117	RFLEQQNKMLETKWS
K117	RFLEQQNKMLETKWS
K122	QNKMLETKWSLLQQQ
K122	QNKMLETKWSLLQQQ
K130	WSLLQQQKTSRSNMD
S142	NMDNMFESYINNLRR
Y143	MDNMFESYINNLRRQ
K158	LEALGQEKLKLEVEL
K160	ALGQEKLKLEVELGN
K176	QGLVEDFKNKYEDEI
K178	LVEDFKNKYEDEINK
Y179	VEDFKNKYEDEINKR
T187	EDEINKRTEMENEFV
K197	ENEFVLIKKDVDEAY
K198	NEFVLIKKDVDEAYM
Y204	KKDVDEAYMNKVELE
K207	VDEAYMNKVELESRL
K207	VDEAYMNKVELESRL
S212	MNKVELESRLEGLTD
H228	INFLRQIHEEEIREL
S253	LSMDNSRSLDMDSII
S258	SRSLDMDSIIAEVRA
R264	DSIIAEVRAQYEEIA
Y267	IAEVRAQYEEIANRS
S274	YEEIANRSRAEAETM
T280	RSRAEAETMYQIKYE
Y282	RAEAETMYQIKYEEL
K285	AETMYQIKYEELQTL
K285	AETMYQIKYEELQTL
K285	AETMYQIKYEELQTL
Y286	ETMYQIKYEELQTLA
T291	IKYEELQTLAGKHGD
K295	ELQTLAGKHGDDLRR
K295	ELQTLAGKHGDDLRR
S303	HGDDLRRSKTEISEM
K304	GDDLRRSKTEISEMN
T305	DDLRRSKTEISEMNR
S308	RRSKTEISEMNRNIS
S315	SEMNRNISRLQAEID
K325	QAEIDALKGQRATLE
K325	QAEIDALKGQRATLE
T330	ALKGQRATLEAAIAD
K347	QRGELAVKDANAKLE
K352	AVKDANAKLEDLKNA
K364	KNALQKAKQDMARQL
Y391	LDIEIATYRKLLEGE
K393	IEIATYRKLLEGEES
K393	IEIATYRKLLEGEES
S400	KLLEGEESRLESGMQ
S410	ESGMQNMSIHTKTTs
T416	MSIHTKTTsGYAGGL
S417-p	SIHTKTTsGYAGGLS
Y419	HTKTTsGYAGGLSSs
S424	sGYAGGLSSsYGGLT
S426-p	YAGGLSSsYGGLTsP
Y427	AGGLSSsYGGLTsPG
T431	SSsYGGLTsPGFSYG
S432-p	SsYGGLTsPGFSYGM
S436	GLTsPGFSYGMSSFQ
Y437	LTsPGFSYGMSSFQP
S441	GFSYGMSSFQPGFGS
P444	YGMSSFQPGFGSVGG
G445	GMSSFQPGFGSVGGS
S448	SFQPGFGSVGGSSTY
S452	GFGSVGGSSTYSRTK
S453	FGSVGGSSTYSRTKA
T454	GSVGGSSTYSRTKAV
S456	VGGSSTYSRTKAVVV
T458	GSSTYSRTKAVVVKK
-	gap
-	gap
-	gap
K464	RTKAVVVKKIETRDG
K465	TKAVVVKKIETRDGK
K472	KIETRDGKLVsEssD
K472	KIETRDGKLVsEssD
S475-p	TRDGKLVsEssDIMS
S475	TRDGKLVSEssDIMS
S477-p	DGKLVsEssDIMSK_
S478-p	GKLVsEssDIMSK__
S482	sEssDIMSK______
K483	EssDIMSK_______
K483	EssDIMSK_______

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