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Protein Page:
AFP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AFP Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular space; cytoplasm
Molecular Function: metal ion binding
Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle
Reference #:  P02771 (UniProtKB)
Alt. Names/Synonyms: AFP; Alpha-1-fetoprotein; Alpha-fetoglobulin; Alpha-fetoprotein; FETA; HPAFP
Gene Symbols: AFP
Molecular weight: 68,678 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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AFP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y164 TFMNKFIYEIARRHP
0 1 T248-p TKLSQKFtKVNFTEI
0 5 S368-p RHPQLAVsVILRVAK
0 5 K413-ac QESQALAkRsCGLFQ
0 2 S415-p SQALAkRsCGLFQKL
  mouse

 
Y160-p VFMNRFIyEVSRRNP
T244 IKLSQKLTEANFTEI
S364 THPNLPVSVILRIAK
K409 EESQALSKQSCALYQ
S411 SQALSKQSCALYQTL
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