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Protein Page:
SATB1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SATB1 Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1- binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Interacts (via DNA-binding domains) with CUX1; leading to inhibit the attachment to DNA. Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts with PCAF. Interacts with sumoylated PML, HDAC1 and HIV-1 Tat via the PDZ- like dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300. Expressed predominantly in thymus. Belongs to the CUT homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Chromosomal Location of Human Ortholog: 3p23
Cellular Component: nucleoplasm; PML body; nuclear matrix; nuclear heterochromatin; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; double-stranded DNA binding; chromatin binding; transcription factor activity
Biological Process: histone methylation; chromatin remodeling; establishment and/or maintenance of chromatin architecture; epidermis development; CD8-positive, alpha-beta T cell differentiation; transcription, DNA-dependent; CD4-positive, alpha beta T cell differentiation; viral reproduction; apoptosis; activated T cell proliferation; negative regulation of transcription from RNA polymerase II promoter; reflex; cell structure disassembly during apoptosis
Reference #:  Q01826 (UniProtKB)
Alt. Names/Synonyms: DNA-binding protein SATB1; SATB homeobox 1; SATB1; special AT-rich sequence binding protein 1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's); Special AT-rich sequence-binding protein 1
Gene Symbols: SATB1
Molecular weight: 85,957 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SATB1

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: T188‑p
molecular association, regulation: T188‑p
sumoylation: T188‑p

Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K24-ac SNNVSDPkGPPAKIA
0 162 S38-p ARLEQNGsPLGRGRL
0 30 S47-p LGRGRLGstGAKMQG
0 2 T48-p GRGRLGstGAKMQGV
1 0 K136-ac KGLIQVGkWNPVPLS
2 0 S185-p DLPPEQWsHTtVRNA
1 0 T188-p PEQWsHTtVRNALKD
0 1 T298-p GSQPSVRtPLPNLHP
0 4 T310-p LHPGLVStPIsPQLV
0 15 S313-p GLVStPIsPQLVNQQ
0 3 Y331-p AQLLNQQyAVNRLLA
0 3 S341-p NRLLAQQsLNQQyLN
0 17 Y346-p QQsLNQQyLNHPPPV
0 1 S366-p KPLEQQVsTNTEVSS
0 6 T466-p GPAPLIStPPsRPPQ
0 1 S469-p PLIStPPsRPPQVKT
0 1 K507 DEIQQEMKRAKVsQA
0 2 S512-p EMKRAKVsQALFAKV
0 1 T522 LFAKVAATKsQGWLC
0 4 S524-p AKVAATKsQGWLCEL
0 1 S557-p SMIRRFLsLPQPERD
0 2 T630-p RLPPRQPtVAsPAEs
0 4 S633-p PRQPtVAsPAEsDEE
0 1 P634 RQPtVAsPAEsDEEN
0 9 S637-p tVAsPAEsDEENRQK
0 1 T649-p RQKTRPRtKIsVEAL
0 1 S652-p TRPRtKIsVEALGIL
2 0 K744-sm TNTLFSVkLEEELSV
4028 : Phospho-SATB1 (Ser47) Antibody
  mouse

 
K24 SNNVSDPKGPPAKIA
S38-p ARLEQNGsPLGRGRL
S47-p LGRGRLGsTGGKMQG
T48 GRGRLGsTGGKMQGV
K136 KGLIQVGKWNPVPLS
S185 DLPPEQWSHTTVRNA
T188 PEQWSHTTVRNALKD
T298 GSQPSVRTPLPNLHP
T310 LHPGLVSTPISPQLV
S313 GLVSTPISPQLVNQQ
Y331 AQLLNQQYAVNRLLA
S341 NRLLAQQSLNQQYLN
Y346 QQSLNQQYLNHPPPV
S366 KPLEQQVSTNTEVSS
T466 GPAPLLSTPPSRPPQ
S469 PLLSTPPSRPPQVKT
K507-ub DEIQQEMkRAKVSQA
S512 EMkRAKVSQALFAKV
T522-p LFAKVAAtKsQGWLC
S524-p AKVAAtKsQGWLCEL
S557 SMIRRFLSLPQPERD
T631 RLPPRQPTVASsAEs
S634 PRQPTVASsAEsDEE
S635-p RQPTVASsAEsDEEN
S638-p TVASsAEsDEENRQK
T650 RQKTRPRTKISVEAL
S653 TRPRTKISVEALGIL
K745 ANTLFSVKLEEELSV
4028 : Phospho-SATB1 (Ser47) Antibody
  rat

 
K24 SNNVSDPKGPPAKIA
S38-p ARLEQNGsPLGRGRL
S47 LGRGRLGSTGGKMQG
T48 GRGRLGSTGGKMQGV
K136 KGLIQVGKWNPVPLS
S185 DLPPEQWSHTTVRNA
T188 PEQWSHTTVRNALKD
T298 GSQPSVRTPLPNLHP
T310 LHPGLVSTPISPQLV
S313 GLVSTPISPQLVNQQ
Y331 AQLLNQQYAVNRLLA
S341 NRLLAQQSLNQQYLN
Y346 QQSLNQQYLNHPPPV
S366 KPLEQQVSTNTEVSS
T466 GPAPLLSTPPSRPPQ
S469 PLLSTPPSRPPQVKT
K507 DEIQQEMKRAKVSQA
S512 EMKRAKVSQALFAKV
T522 LFAKVAATKSQGWLC
S524 AKVAATKSQGWLCEL
S557 SMIRRFLSLPQPERD
T631 RLPPRQPTVASSAEs
S634 PRQPTVASSAEsDEE
S635 RQPTVASSAEsDEEN
S638-p TVASSAEsDEENRQK
T650 RQKTRPRTKISVEAL
S653 TRPRTKISVEALGIL
K745 ANTLFSVKLEEELSV
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