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Protein Page:
IL3 (human)

IL3 Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Secreted; Cell cycle regulation; Secreted, signal peptide; Apoptosis; Cytokine
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: extracellular space; extracellular region; intracellular
Molecular Function: interleukin-3 receptor binding; growth factor activity; cytokine activity
Biological Process: epidermal growth factor receptor signaling pathway; nervous system development; axon guidance; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; embryonic hemopoiesis; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; cell-cell signaling; small GTPase mediated signal transduction; positive regulation of cell proliferation; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; positive regulation of myeloid leukocyte differentiation; vascular endothelial growth factor receptor signaling pathway; positive regulation of DNA replication
Reference #:  P08700 (UniProtKB)
Alt. Names/Synonyms: Hematopoietic growth factor; IL-3; IL3; interleukin 3 (colony-stimulating factor, multiple); Interleukin-3; Mast cell growth factor; mast-cell growth factor; MCGF; MGC79398; MGC79399; MULTI-CSF; multilineage-colony-stimulating factor; Multipotential colony-stimulating factor; P-cell stimulating factor; P-cell-stimulating factor
Gene Symbols: IL3
Molecular weight: 17,233 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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