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IL29
Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. Note: This description may include information from UniProtKB.
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| Protein type: Secreted, signal peptide; Secreted; Cytokine; Cell cycle regulation |
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Cellular Component: extracellular space; extracellular region; interleukin-28 receptor complex
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Molecular Function: cytokine activity; interleukin-28 receptor binding; receptor binding
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Biological Process: positive regulation of immune response; positive regulation of transcription, DNA-dependent; positive regulation of JAK-STAT cascade; negative regulation of T cell differentiation; negative regulation of cell proliferation; negative regulation of interleukin-13 production; positive regulation of interferon-gamma production; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of T-helper 2 type immune response; negative regulation of interleukin-5 production; positive regulation of MHC class I biosynthetic process; negative regulation of memory T cell differentiation; negative regulation of transcription, DNA-dependent; defense response to virus
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Reference #:
Q8IU54 (UniProtKB)
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| Alt. Names/Synonyms: cytokine Zcyto21; IFN-lambda-1; IFNL1; interferon lambda-1; interleukin-29; ZCYTO21 |
| Gene Symbols: IFNL1 |
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Molecular weight: 21,898 Da
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Basal Isoelectric point: 9.08
Predict pI for various phosphorylation states
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