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Protein Page:
MAML1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MAML1 Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8. Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. Belongs to the mastermind family. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleolus; nuclear speck; nucleus
Molecular Function: protein binding; peptide antigen binding; transcription coactivator activity; protein kinase binding
Biological Process: myoblast differentiation; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation
Reference #:  Q92585 (UniProtKB)
Alt. Names/Synonyms: FLJ53540; KIAA0200; Mam-1; Mam1; MAML1; mastermind homolog; mastermind-like 1 (Drosophila); Mastermind-like protein 1
Gene Symbols: MAML1
Molecular weight: 108,054 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MAML1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S35-p ELCRRHHsTCEARYE
0 5 S45-p EARYEAVsPERLELE
0 4 S120-p RNLDSATsPQNGDQQ
0 25 K138-ac GDLFPGHkktRREAP
0 4 K139-ac DLFPGHkktRREAPL
0 1 T140-p LFPGHkktRREAPLG
0 1 S185-p KHSLGLDsLNkKRLA
0 1 K188-ac LGLDsLNkKRLADSS
1 0 K217-sm LSLNKELkQEPVEDL
0 1 S261-p LIEELNRsVPDEDMK
0 1 S286-p KDPESSGsAtQtPLA
0 1 T288-p PESSGsAtQtPLAQD
0 2 T290-p SSGsAtQtPLAQDIN
1 0 K299-sm LAQDINIktEFsPAA
0 1 T300-p AQDINIktEFsPAAF
0 5 S303-p INIktEFsPAAFEQE
0 6 S314-p FEQEQLGsPQVRAGS
0 3 S338-p SAPVSTDsPSLGGsQ
0 1 S344-p DsPSLGGsQtLFHTS
0 1 T346-p PSLGGsQtLFHTSGQ
0 4 S360-p QPRADNPsPNLMPAS
0 1 S451-p YPMEKPAsPSSYKQD
0 5 K822-ac TLNPGLTkPPVPRVS
0 1 S1007-p RTSEEWMsDLDDLLG
0 3 S1015-p DLDDLLGsQ______
  mouse

 
S35 ELCRRHHSTCEARYE
S45-p EARYEAVsPERLELE
S127-p RSLDSAAsPQNGDQP
K145 GDLFPGHKKTRREAP
K146 DLFPGHKKTRREAPL
T147 LFPGHKKTRREAPLG
P192 KHSLGLDPINKKCLA
K195 LGLDPINKKCLADSG
K224 LSLSKELKQEPVDDL
S268 LIEELNRSVPDEDMK
S293 KDPEPPGSATQTPLA
T295 PEPPGSATQTPLAQD
T297 PPGSATQTPLAQDIN
K306 LAQDINIKtEFsPAA
T307-p AQDINIKtEFsPAAF
S310-p INIKtEFsPAAFEQE
S321-p FEQEQLGsPQVRAGS
S345 SAPVGTDSPSLGSSQ
S351 DSPSLGSSQTLFHTT
T353 PSLGSSQTLFHTTSQ
S367 QPGVDNSSPNLMPAS
S458 YPMEKPASPSGYKQD
K827 TLPPGLTKPQVPRVS
N1011 RTSEEWINELDDLLG
S1019-p ELDDLLGsQ______
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