Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Apoptosis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9q32
Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; integral to membrane