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IL21 (human)

Overview IL21 Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Cell development/differentiation; Secreted; Cytokine; Secreted, signal peptide; Apoptosis Cellular Component: extracellular space Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding; cytokine activity Biological Process: positive regulation of natural killer cell differentiation; positive regulation of interleukin-17 production; positive regulation of tissue remodeling; positive regulation of natural killer cell cytokine production; cell maturation; positive regulation of T cell proliferation; immune response; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; positive regulation of interleukin-10 production; positive regulation of interferon-gamma biosynthetic process; positive regulation of inflammatory response Reference #:  Q9HBE4 (UniProtKB) Alt. Names/Synonyms: IL-21; interleukin 21; Interleukin-21; Za11 Gene Symbols: IL21 Molecular weight: 17,923 Da Basal Isoelectric point: 9.42  Predict pI for various phosphorylation states

Select Structure to View Below IL21 2OQP - A=23-155 (human) 3TGX - H/F/J/N/D/P/L/B=23-155 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 2OQP 3TGX  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S102-p	KLKRKPPstNAGRRQ
0	1		T103-p	LKRKPPstNAGRRQK

	mouse
-	under review
-	under review

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