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Protein Page:
IL21 (human)

IL21 Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cytokine; Secreted, signal peptide; Cell development/differentiation; Secreted
Chromosomal Location of Human Ortholog: 4q26-q27
Cellular Component: extracellular space; intracellular
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding; cytokine activity
Biological Process: positive regulation of cytokine production; positive regulation of interleukin-17 production; positive regulation of natural killer cell cytokine production; cell maturation; tyrosine phosphorylation of Stat3 protein; signal transduction; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of interleukin-10 production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of cell proliferation; positive regulation of B cell proliferation; immune response; positive regulation of T cell proliferation; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process
Disease: Immunodeficiency, Common Variable, 11
Reference #:  Q9HBE4 (UniProtKB)
Alt. Names/Synonyms: IL-21; interleukin 21; Interleukin-21; Za11
Gene Symbols: IL21
Molecular weight: 17,923 Da
Basal Isoelectric point: 9.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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