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Protein Page:
MBL2 (human)

Overview
MBL2 Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space; cell surface; collagen; extracellular region
Molecular Function: mannose binding; protein binding; calcium-dependent protein binding; receptor binding
Biological Process: defense response to Gram-positive bacterium; killing by host of symbiont cells; positive regulation of phagocytosis; defense response to bacterium; acute-phase response; innate immune response; opsonization; response to oxidative stress; complement activation, lectin pathway; complement activation, classical pathway; negative regulation of viral reproduction; complement activation
Reference #:  P11226 (UniProtKB)
Gene Symbols: MBL2
Molecular weight: 26,144 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Select Structure to View Below

MBL2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S100-p QKGDPGKsPDGDSSL
0 1 S110-p GDSSLAAsERKALQT
  mouse

 
- under review  
- under review  
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