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eIF4G iso3 (human)

Overview eIF4G iso3 Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis. Interacts with RBM4. Belongs to the eIF4G family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Translation initiation; Translation Cellular Component: eukaryotic translation initiation factor 4F complex; cytoplasm; cytosol Molecular Function: protein binding; DNA binding; translation factor activity, nucleic acid binding; translation initiation factor activity Biological Process: cell death; translation; cytokine and chemokine mediated signaling pathway; mRNA metabolic process; poly(A) tail shortening; cellular protein metabolic process; RNA metabolic process; virus-host interaction; translational initiation; insulin receptor signaling pathway; mRNA catabolic process, nonsense-mediated decay; gene expression; regulation of translational initiation; mRNA catabolic process, deadenylation-dependent decay Reference #:  Q04637-3 (UniProtKB) Alt. Names/Synonyms: DKFZp686A1451; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; EIF4-gamma; EIF4F; EIF4G; EIF4G1; EIF4GI; Eukaryotic translation initiation factor 4 gamma 1; eukaryotic translation initiation factor 4 gamma, 1; IF4G1; p220 Gene Symbols: EIF4G1 Molecular weight: 171,514 Da Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states CST Pathways:  Translation: eIF4E and p70S6K  |  Translational Control Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below eIF4G iso3 1LJ2 - C/D=172-199 (human) 1UG3 - A/B=1234-1572 (human) 2W97 - F/E=413-426 (human) 4F02 - A/D=1-190 (human)

Scansite  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S15	TGPPPAPSPGLPQPA
0	3		R48-m2	MNTPSQPrQHFyPSr
0	1		Y52-p	SQPrQHFyPSrAQPP
0	4		R55-m1	rQHFyPSrAQPPSsA
0	2		R55-m2	rQHFyPSrAQPPSsA
0	1		S61-gl	SrAQPPSsAASRVQS
0	15		Y103-p	YPASQGAyYIPGQGr
0	6		R110-m1	yYIPGQGrSTYVVPT
0	1		K190	RDPNQGGKDITEEIM
0	4		T202-p	EIMSGARtAstPtPP
0	6		S204-p	MSGARtAstPtPPQt
0	24		T205-p	SGARtAstPtPPQtG
0	17		T207-p	ARtAstPtPPQtGGG
0	9		T211-p	stPtPPQtGGGLEPQ
0	2		G214	tPPQtGGGLEPQANG
0	6		T223-p	EPQANGEtPQVAVIV
0	5		T301-p	QMSVEEStPISRETG
0	6		Y311-p	SRETGEPyRLsPEPt
0	11		S314-p	TGEPyRLsPEPtPLA
0	1		T318-p	yRLsPEPtPLAEPIL
0	1		K524	KIKELNKKEAVGDLL
0	1		K580-u	TWDSKEDkIHNAENI
0	4		K593-u	NIQPGEQkyEYksDQ
0	29		Y594-p	IQPGEQkyEYksDQW
0	3		K597-u	GEQkyEYksDQWkPL
0	1		S598-p	EQkyEYksDQWkPLN
0	6		K602-u	EYksDQWkPLNLEEk
0	1		K609-u	kPLNLEEkKRYDREF
1	7		T647-p	VLDKANKtPLRPLDP
0	12		T667-p	INCGPDFtPsFANLG
0	1		S669-p	CGPDFtPsFANLGrT
0	4		R675-m1	PsFANLGrTTLSTrG
0	1		R681-m1	GrTTLSTrGPPrGGP
0	30		R685-m1	LSTrGPPrGGPGGEL
0	1		R702-m1	GPAGLGPrRsQQGPR
1	6		S704-p	AGLGPrRsQQGPRKE
0	1		T722	IIATVLMTEDIKLNK
0	1		S755-p	GEEDADGsKTQDLFR
0	3		K770-u	RVRSILNkLTPQMFQ
0	1		K781-u	QMFQQLMkQVTQLAI
0	1		T790	VTQLAIDTEERLkGV
0	2		K795-u	IDTEERLkGVIDLIF
0	7		K832-u	LKVPTTEkPTVTVNF
0	1		K863-u	DDDEVFEkKQKEMDE
0	3		K881-u	AEERGRLkEELEEAR
1	0		S895-p	RDIARRRsLGNIkFI
0	2		K900-u	RRsLGNIkFIGELFK
0	3		K925-u	DCVVKLLkNHDEESL
0	2		K944-u	RLLTTIGkDLDFEkA
0	2		K950-u	GkDLDFEkAKPRMDQ
0	1		K964-u	QYFNQMEkIIkEKKT
0	1		K967-u	NQMEkIIkEKKTSSR
0	2		S1028-p	QQLMAKGsDKRrGGP
0	6		R1032-m1	AKGsDKRrGGPPGPP
0	6		R1042-m1	PPGPPISrGLPLVDD
0	6		T1054-p	VDDGGWNtVPISkGS
0	2		K1059-u	WNtVPISkGSRPIDt
0	6		T1066-p	kGSRPIDtSRLTKIt
1	0		T1073-p	tSRLTKItKPGsIDs
0	1		K1074	SRLTKItKPGsIDsN
0	8		S1077-p	TKItKPGsIDsNNQL
1	1		S1080-p	tKPGsIDsNNQLFAP
1	17		S1092-p	FAPGGRLsWGkGSsG
0	1		K1095-a	GGRLsWGkGSsGGsG
0	1		S1098-p	LsWGkGSsGGsGAKP
0	1		S1101-p	GkGSsGGsGAKPSDA
2	0		S1106	GGsGAKPSDAAsEAA
0	2		S1110-p	AKPSDAAsEAARPAT
1	0		T1119-p	AARPATStLNRFSAL
1	1		S1144-p	NRRVVQRssLsRERG
1	6		S1145-p	RRVVQRssLsRERGE
14	9		S1147-p	VVQRssLsRERGEKA
0	13		T1179-p	DRLDRARtPAtKRsF
0	2		T1182-p	DRARtPAtKRsFskE
2	154		S1185-p	RtPAtKRsFskEVEE
2	41		S1187-p	PAtKRsFskEVEERs
0	1		K1188-a	AtKRsFskEVEERsR
0	7		S1194-p	skEVEERsRERPSQP
0	27		S1209-p	EGLRKAAsLtEDRDR
0	8		T1211-p	LRKAAsLtEDRDRGR
0	2		A1226	DAVKREAALPPVsPL
3	88		S1231-p	EAALPPVsPLKAALs
1	6		S1238-p	sPLKAALsEEELEKK
0	1		Y1253-p	SKAIIEEyLHLNDMK
0	1		K1404-u	REAGLSWkEFLPEGQ
0	1		Y1424-p	VAEQKVEytLGEEsE
0	1		T1425-p	AEQKVEytLGEEsEA
0	1		S1430-p	EytLGEEsEAPGQRA
0	1		T1477	EQQIVSNTLVRALMT
0	1		Y1550-p	RMFFDALyDEDVVKE
0	1		K1580-u	QGKGVALkSVTAFFK
0	16		S1596-p	LREAEEEsDHN____

	eIF4G iso1
S15	TGPPPAPSPGLPQPA
R48	MNTPSQPRQHFYPSR
Y52	SQPRQHFYPSRAQPP
R55	RQHFYPSRAQPPSSA
R55	RQHFYPSRAQPPSSA
S61	SRAQPPSSAASRVQS
Y103	YPASQGAYYIPGQGR
R110	YYIPGQGRSTYVVPT
K190	RDPNQGGKDITEEIM
T202	EIMSGARTASTPTPP
S204	MSGARTASTPTPPQT
T205	SGARTASTPTPPQTG
T207	ARTASTPTPPQTGGG
T211	STPTPPQTGGGLEPQ
G214	TPPQTGGGLEPQANG
T223	EPQANGETPQVAVIV
T301	QMSVEESTPISRETG
Y311	SRETGEPYRLSPEPT
S314	TGEPYRLSPEPTPLA
T318	YRLSPEPTPLAEPIL
K524	KIKELNKKEAVGDLL
K580	TWDSKEDKIHNAENI
K593	NIQPGEQKYEYKSDQ
Y594	IQPGEQKYEYKSDQW
K597	GEQKYEYKSDQWKPL
S598	EQKYEYKSDQWKPLN
K602	EYKSDQWKPLNLEEK
K609	KPLNLEEKKRYDREF
T647	VLDKANKTPLRPLDP
T667	INCGPDFTPSFANLG
S669	CGPDFTPSFANLGRT
R675	PSFANLGRTTLSTRG
R681	GRTTLSTRGPPRGGP
R685	LSTRGPPRGGPGGEL
R703	PQAGLGPRRSQQGPR
S705	AGLGPRRSQQGPRKE
T723	IIATVLMTEDIKLNK
S756	GEEDADGSKTQDLFR
K771	RVRSILNKLTPQMFQ
K782	QMFQQLMKQVTQLAI
T791	VTQLAIDTEERLKGV
K796	IDTEERLKGVIDLIF
K833	LKVPTTEKPTVTVNF
K864	DDDEVFEKKQKEMDE
K882	AEERGRLKEELEEAR
S896	RDIARRRSLGNIKFI
K901	RRSLGNIKFIGELFK
K926	DCVVKLLKNHDEESL
K945	RLLTTIGKDLDFEKA
K951	GKDLDFEKAKPRMDQ
K965	QYFNQMEKIIKEKKT
K968	NQMEKIIKEKKTSSR
S1029	QQLMAKGSDKRRGGP
R1033	AKGSDKRRGGPPGPP
R1043	PPGPPISRGLPLVDD
T1055	VDDGGWNTVPISKGS
K1060	WNTVPISKGSRPIDT
T1067	KGSRPIDTSRLTKIT
T1074	TSRLTKITKPGSIDS
K1075	SRLTKITKPGSIDSN
S1078	TKITKPGSIDSNNQL
S1081	TKPGSIDSNNQLFAP
S1093	FAPGGRLSWGKGSSG
K1096	GGRLSWGKGSSGGSG
S1099	LSWGKGSSGGSGAKP
S1102	GKGSSGGSGAKPSDA
S1107	GGSGAKPSDAASEAA
S1111	AKPSDAASEAARPAT
T1120	AARPATSTLNRFSAL
S1145	NRRVVQRSSLsRERG
S1146	RRVVQRSSLsRERGE
S1148-p	VVQRSSLsRERGEKA
T1180	DRLDRARTPATKRsF
T1183	DRARTPATKRsFSKE
S1186-p	RTPATKRsFSKEVEE
S1188	PATKRsFSKEVEERS
K1189	ATKRsFSKEVEERSR
S1195	SKEVEERSRERPSQP
S1210	EGLRKAASLTEDRDR
T1212	LRKAASLTEDRDRGR
A1226	RDAVKREAALPPVsP
S1232-p	EAALPPVsPLKAALs
S1239-p	sPLKAALsEEELEKK
Y1254	SKAIIEEYLHLNDMK
K1405	REAGLSWKEFLPEGQ
Y1425	VAEQKVEYTLGEESE
T1426	AEQKVEYTLGEESEA
S1431	EYTLGEESEAPGQRA
T1478	EQQIVSNTLVRALMT
Y1551	RMFFDALYDEDVVKE
K1581	QGKGVALKSVTAFFK
S1597	LREAEEESDHN____

	eIF4G iso3
-	gap
R8	MNTPSQPRQHFYPSR
Y12	SQPRQHFYPSRAQPP
R15	RQHFYPSRAQPPSSA
R15	RQHFYPSRAQPPSSA
S21	SRAQPPSSAASRVQS
Y63	YPASQGAYYIPGQGR
R70	YYIPGQGRSTYVVPT
K150	RDPNQGGKDITEEIM
T162	EIMSGARTAStPtPP
S164	MSGARTAStPtPPQT
T165-p	SGARTAStPtPPQTG
T167-p	ARTAStPtPPQTGGG
T171	StPtPPQTGGGLEPQ
G174	tPPQTGGGLEPQANG
T183	EPQANGETPQVAVIV
T261	QMSVEESTPISRETG
Y271	SRETGEPYRLSPEPT
S274	TGEPYRLSPEPTPLA
T278	YRLSPEPTPLAEPIL
K484	KIKELNKKEAVGDLL
K540	TWDSKEDKIHNAENI
K553	NIQPGEQKyEYKSDQ
Y554-p	IQPGEQKyEYKSDQW
K557	GEQKyEYKSDQWKPL
S558	EQKyEYKSDQWKPLN
K562	EYKSDQWKPLNLEEK
K569	KPLNLEEKKRYDREF
T607	VLDKANKTPLRPLDP
T627	INCGPDFTPSFANLG
S629	CGPDFTPSFANLGRT
R635	PSFANLGRTTLSTRG
R641	GRTTLSTRGPPRGGP
R645	LSTRGPPRGGPGGEL
R663	PAGLGPRRSQQGPRK
S664	AGLGPRRSQQGPRKE
T682	IIATVLMTEDIKLNK
S715	GEEDADGSKTQDLFR
K730	RVRSILNKLTPQMFQ
K741	QMFQQLMKQVTQLAI
T750	VTQLAIDTEERLKGV
K755	IDTEERLKGVIDLIF
K792	LKVPTTEKPTVTVNF
K823	DDDEVFEKKQKEMDE
K841	AEERGRLKEELEEAR
S855	RDIARRRSLGNIKFI
K860	RRSLGNIKFIGELFK
K885	DCVVKLLKNHDEESL
K904	RLLTTIGKDLDFEKA
K910	GKDLDFEKAKPRMDQ
K924	QYFNQMEKIIKEKKT
K927	NQMEKIIKEKKTSSR
S988	QQLMAKGSDKRRGGP
R992	AKGSDKRRGGPPGPP
R1002	PPGPPISRGLPLVDD
T1014	VDDGGWNTVPISKGS
K1019	WNTVPISKGSRPIDT
T1026	KGSRPIDTSRLTKIT
T1033	TSRLTKITKPGSIDS
K1034	SRLTKITKPGSIDSN
S1037	TKITKPGSIDSNNQL
S1040	TKPGSIDSNNQLFAP
S1052	FAPGGRLSWGKGSSG
K1055	GGRLSWGKGSSGGSG
S1058	LSWGKGSSGGSGAKP
S1061	GKGSSGGSGAKPSDA
S1066	GGSGAKPSDAASEAA
S1070	AKPSDAASEAARPAT
T1079	AARPATSTLNRFSAL
S1104	NRRVVQRSSLsRERG
S1105	RRVVQRSSLsRERGE
S1107-p	VVQRSSLsRERGEKA
T1139-p	DRLDRARtPATKRsF
T1142	DRARtPATKRsFsKE
S1145-p	RtPATKRsFsKEVEE
S1147-p	PATKRsFsKEVEERS
K1148	ATKRsFsKEVEERSR
S1154	sKEVEERSRERPSQP
S1169	EGLRKAASLTEDRDR
T1171	LRKAASLTEDRDRGR
A1186	DAVKREAALPPVsPL
S1191-p	EAALPPVsPLKAALS
S1198	sPLKAALSEEELEKK
Y1213	SKAIIEEYLHLNDMK
K1364	REAGLSWKEFLPEGQ
Y1384	VAEQKVEYTLGEESE
T1385	AEQKVEYTLGEESEA
S1390	EYTLGEESEAPGQRA
T1437	EQQIVSNTLVRALMT
Y1510	RMFFDALYDEDVVKE
K1540	QGKGVALKSVTAFFK
S1556	LREAEEESDHN____

	mouse ► Hide Isoforms
S15-p	TGPPPARsPGLPQPA
R48	MNTPSQPRQGGFRSL
Y59	FRSLQHFYPSrAQPP
R62-m1	LQHFYPSrAQPPSSA
R62	LQHFYPSRAQPPSSA
S68	SrAQPPSSAASRVQS
Y110-p	YSASQGAyYIPGQGr
R117-m1	yYIPGQGrSTYVVPT
K197-u	RDPNQGGkDITEEIM
T209-p	EIMSGARtAstPtPP
S211-p	MSGARtAstPtPPQt
T212-p	SGARtAstPtPPQtG
T214-p	ARtAstPtPPQtGGs
T218-p	stPtPPQtGGsLEPQ
S221-p	tPPQtGGsLEPQPNG
S230-p	EPQPNGEsPQVAVII
T311	PMSVEESTPISCETG
Y321	SCETGEPYCLSPEPT
S324	TGEPYCLSPEPTLAE
T328	YCLSPEPTLAEPILE
K528-u	KIKELNKkEAVGDLL
K584	TWDSKEDKIHNAENI
K597-u	NIQPGEQkyEYkSDQ
Y598-p	IQPGEQkyEYkSDQW
K601-u	GEQkyEYkSDQWkPL
S602	EQkyEYkSDQWkPLN
K606-u	EYkSDQWkPLNLEEK
K613	kPLNLEEKKRYDREF
T651	VLDKANKTPLRQLDP
T671	INCGPDFTPSFANLG
S673	CGPDFTPSFANLGRP
R679	PSFANLGRPALSNRG
R685	GRPALSNRGPPrGGP
R689-m1	LSNRGPPrGGPGGEL
R706	GPAGLGPRRsQQGPR
S708-p	AGLGPRRsQQGPRKE
T726-p	IISSVIMtEDIKLNK
S759	GEEDADGSKTQDLFR
K774-u	RVRSILNkLTPQMFQ
K785	QMFQQLMKQVTQLAI
T794-p	VTQLAIDtEERLkGV
K799-u	IDtEERLkGVIDLIF
K836	LKVPTTEKPTVTVNF
K867	DDDEVFEKKQKEMDE
K885-u	AEERGRLkEELEEAR
S899	RDIARRRSLGNIkFI
K904-u	RRSLGNIkFIGELFK
K929	DCVVKLLKNHDEESL
K948	RLLTTIGKDLDFAkA
K954-u	GKDLDFAkAKPRMDQ
K968	QYFNQMEKIIKEKKT
K971	NQMEKIIKEKKTSSR
S1032	QQLMAKGSDKRrGGP
R1036-m1	AKGSDKRrGGPPGPP
R1046	PPGPPINRGLPLVDD
T1058-p	VDDGGWNtVPISKGS
K1063	WNtVPISKGSRPIDT
T1070	KGSRPIDTSRLTKIT
T1077	TSRLTKITkPGsIDs
K1078-u	SRLTKITkPGsIDsN
S1081-p	TKITkPGsIDsNNQL
S1084-p	TkPGsIDsNNQLFAP
S1096-p	FAPGGRLsWGKGSSG
K1099	GGRLsWGKGSSGGSG
S1102	LsWGKGSSGGSGAKP
S1105	GKGSSGGSGAKPSDT
S1110	GGSGAKPSDTAsEAT
S1114-p	AKPSDTAsEATRPAT
T1121	sEATRPATLNRFSAL
S1146	NRRVVQRSsLsRERG
S1147-p	RRVVQRSsLsRERGE
S1149-p	VVQRSsLsRERGEKA
T1181-p	DRLDRARtPAtKRsF
T1184-p	DRARtPAtKRsFsKE
S1187-p	RtPAtKRsFsKEVEE
S1189-p	PAtKRsFsKEVEERs
K1190	AtKRsFsKEVEERsR
S1196-p	sKEVEERsRERPSQP
S1211-p	EGLRKAAsLtEDRGR
T1213-p	LRKAAsLtEDRGRDP
T1226-p	DPVKREAtLPPVsPP
S1231-p	EAtLPPVsPPKAALS
S1238	sPPKAALSVDEVEKK
Y1253	SKAIIEEYLHLNDMK
R1404	REAGLSWREFLAEGQ
Y1424	VAEKKVEYTLGEESE
T1425	AEKKVEYTLGEESEA
S1430	EYTLGEESEAPGQRT
T1477-p	EQQIASNtLVRALMT
Y1550	RMFFDALYDEDVVKE
K1580	QGKGVALKSVTAFFN
S1597-p	REAEDEEsDHN____

	eIF4G iso2
S15	TGPPPARSPGLPQPA
R48-m2	MNTPSQPrQHFYPSr
Y52	SQPrQHFYPSrAQPP
R55	rQHFYPSRAQPPSSA
R55-m2	rQHFYPSrAQPPSSA
S61	SrAQPPSSAASRVQS
Y103	YSASQGAYYIPGQGR
R110	YYIPGQGRSTYVVPT
K190	RDPNQGGKDITEEIM
T202	EIMSGARTASTPTPP
S204	MSGARTASTPTPPQT
T205	SGARTASTPTPPQTG
T207	ARTASTPTPPQTGGS
T211	STPTPPQTGGSLEPQ
S214	TPPQTGGSLEPQPNG
S223	EPQPNGESPQVAVII
T304	PMSVEESTPISCETG
Y314	SCETGEPYCLSPEPT
S317	TGEPYCLSPEPTLAE
T321	YCLSPEPTLAEPILE
K521	KIKELNKKEAVGDLL
K577	TWDSKEDKIHNAENI
K590	NIQPGEQKYEYKSDQ
Y591	IQPGEQKYEYKSDQW
K594	GEQKYEYKSDQWKPL
S595	EQKYEYKSDQWKPLN
K599	EYKSDQWKPLNLEEK
K606	KPLNLEEKKRYDREF
T644	VLDKANKTPLRQLDP
T664	INCGPDFTPSFANLG
S666	CGPDFTPSFANLGRP
R672	PSFANLGRPALSNRG
R678	GRPALSNRGPPRGGP
R682	LSNRGPPRGGPGGEL
R699	GPAGLGPRRSQQGPR
S701	AGLGPRRSQQGPRKE
T719	IISSVIMTEDIKLNK
S752	GEEDADGSKTQDLFR
K767	RVRSILNKLTPQMFQ
K778	QMFQQLMKQVTQLAI
T787	VTQLAIDTEERLKGV
K792	IDTEERLKGVIDLIF
K829	LKVPTTEKPTVTVNF
K860	DDDEVFEKKQKEMDE
K878	AEERGRLKEELEEAR
S892	RDIARRRSLGNIKFI
K897	RRSLGNIKFIGELFK
K922	DCVVKLLKNHDEESL
K941	RLLTTIGKDLDFAKA
K947	GKDLDFAKAKPRMDQ
K961	QYFNQMEKIIKEKKT
K964	NQMEKIIKEKKTSSR
S1025	QQLMAKGSDKRRGGP
R1029	AKGSDKRRGGPPGPP
-	gap
T1044	INDGGWNTVPISKGS
K1049	WNTVPISKGSRPIDT
T1056	KGSRPIDTSRLTKIT
T1063	TSRLTKITKPGSIDS
K1064	SRLTKITKPGSIDSN
S1067	TKITKPGSIDSNNQL
S1070	TKPGSIDSNNQLFAP
S1082	FAPGGRLSWGKGSSG
K1085	GGRLSWGKGSSGGSG
S1088	LSWGKGSSGGSGAKP
S1091	GKGSSGGSGAKPSDT
S1096	GGSGAKPSDTASEAT
S1100	AKPSDTASEATRPAT
T1107	SEATRPATLNRFSAL
S1132	NRRVVQRSSLSRERG
S1133	RRVVQRSSLSRERGE
S1135	VVQRSSLSRERGEKA
T1167	DRLDRARTPATKRSF
T1170	DRARTPATKRSFSKE
S1173	RTPATKRSFSKEVEE
S1175	PATKRSFSKEVEERS
K1176	ATKRSFSKEVEERSR
S1182	SKEVEERSRERPSQP
S1197	EGLRKAASLTEDRGR
T1199	LRKAASLTEDRGRDP
T1212	DPVKREATLPPVSPP
S1217	EATLPPVSPPKAALS
S1224	SPPKAALSVDEVEKK
Y1239	SKAIIEEYLHLNDMK
R1390	REAGLSWREFLAEGQ
Y1410	VAEKKVEYTLGEESE
T1411	AEKKVEYTLGEESEA
S1416	EYTLGEESEAPGQRT
T1463	EQQIASNTLVRALMT
Y1536	RMFFDALYDEDVVKE
K1566	QGKGVALKSVTAFFN
S1583	REAEDEESDHN____

	rat
S15	TGPPPARSPGLPQPA
R48	MNTPSQPRQGGFRSL
Y59	FRSLQHFYPSRAQPP
R62	LQHFYPSRAQPPSSA
R62	LQHFYPSRAQPPSSA
S68	SRAQPPSSAASRVQS
Y110	YSASQGAYYIPGQGR
R117	YYIPGQGRSTYVVPT
K197	RDPNQGGKDITEEIM
T209	EIMSGARTASTPTPP
S211	MSGARTASTPTPPQT
T212	SGARTASTPTPPQTG
T214	ARTASTPTPPQTGGS
T218	STPTPPQTGGSLEPQ
S221	TPPQTGGSLEPQPNG
S230	EPQPNGESPQVAVII
T311	PISVEESTPISCESG
Y321	SCESGEPYCLSPEPT
S324	SGEPYCLSPEPTLAE
T328	YCLSPEPTLAEPILE
K526	KIKELNKKEAVGDLL
K582	TWDSKEDKIHNAENI
K595	NIQPGEQKYEYKSDQ
Y596	IQPGEQKYEYKSDQW
K599	GEQKYEYKSDQWKPL
S600	EQKYEYKSDQWKPLN
K604	EYKSDQWKPLNLEEK
K611	KPLNLEEKKRYDREF
T649	VLDKANKTPLRSLDP
T669	INCGPDFTPSFANLG
S671	CGPDFTPSFANLGRP
R677	PSFANLGRPTLSSRG
R683	GRPTLSSRGPPrGGP
R687-m1	LSSRGPPrGGPGGEL
R704	GPAGLGPRRSQQGPR
S706	AGLGPRRSQQGPRKE
T724	IISSVIMTEDIKLNK
S757	GEEDADGSKTQDLFR
K772	RVRSILNKLTPQMFQ
K783	QMFQQLMKQVTQLAI
T792	VTQLAIDTEERLKGV
K797	IDTEERLKGVIDLIF
K834	LKVPTTEKPTVTVNF
K865	DDDEVFEKKQKEMDE
K883	AEERGRLKEELEEAR
S897	RDIARRRSLGNIKFI
K902	RRSLGNIKFIGELFK
K927	DCVVKLLKNHDEESL
K946	RLLTTIGKDLDFAKA
K952	GKDLDFAKAKPRMDQ
K966	QYFNQMEKIIKEKKT
K969	NQMEKIIKEKKTSSR
G1030	QQLMAKGGDKRRGGP
R1034	AKGGDKRRGGPPGPP
R1044	PPGPPVNRGLPLVDD
T1056	VDDGGWNTVPISKGS
K1061	WNTVPISKGSRPIDT
T1068	KGSRPIDTSRLTKIT
T1075	TSRLTKITKPGSIDS
K1076	SRLTKITKPGSIDSN
S1079	TKITKPGSIDSNNQL
S1082	TKPGSIDSNNQLFAP
S1094	FAPGGRLSWGKGSSG
K1097	GGRLSWGKGSSGGSG
S1100	LSWGKGSSGGSGAKP
S1103	GKGSSGGSGAKPsDT
S1108-p	GGSGAKPsDTASEAT
S1112	AKPsDTASEATRPAT
T1119	SEATRPATLNRFSAL
S1144	NRRVVQRSSLsRERG
S1145	RRVVQRSSLsRERGE
S1147-p	VVQRSSLsRERGEKA
T1179	DRLDRARTPATKRsF
T1182	DRARTPATKRsFsKE
S1185-p	RTPATKRsFsKEVEE
S1187-p	PATKRsFsKEVEERS
K1188	ATKRsFsKEVEERSR
S1194	sKEVEERSRERPSQP
S1209-p	EGLRKAAsLTEDRGR
T1211	LRKAAsLTEDRGRDP
T1224	DPVKREATLPPVsPP
S1229-p	EATLPPVsPPKAALA
A1236	sPPKAALAVDEVERK
Y1251	SKAIIEEYLHLNDMK
R1402	REAGLSWREFLAEGQ
Y1422	VAEKKVEYTLGEESE
T1423	AEKKVEYTLGEESEA
S1428	EYTLGEESEAPGQRA
T1475	EQQIASNTLVRALMT
Y1548	RMFFDALYDEDVVKE
K1578	QGKGVALKSVTAFFN
S1595-p	REAEDEEsDHN____

	rabbit
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
T6	__MSGARTVSTPTPP
S8	MSGARTVSTPTPPQT
T9	SGARTVSTPTPPQTG
T11	ARTVSTPTPPQTGGG
T15	STPTPPQTGGGVEPQ
G18	TPPQTGGGVEPQANG
T27	EPQANGETPQVAVIV
A107	QMPVEEPAPISREAG
Y117	SREAGEPYCLSPEPT
S120	AGEPYCLSPEPTPLA
T124	YCLSPEPTPLAEPIL
K329	KIKELNKKEAVGDLL
K385	TWDAKEDKIHNAENI
K398	NIQPGEQKYEYKSDQ
Y399	IQPGEQKYEYKSDQW
K402	GEQKYEYKSDQWRPL
S403	EQKYEYKSDQWRPLN
R407	EYKSDQWRPLNLEEK
K414	RPLNLEEKKRYDREF
T452	VLEKANKTPLRPLDP
T472	INCGPDFTPSFANLG
S474	CGPDFTPSFANLGRP
R480	PSFANLGRPALSSRG
R486	GRPALSSRGPPRGGP
R490	LSSRGPPRGGPGGEL
R507	GAAGLGPRRSLQPRP
S509	AGLGPRRSLQPRPPK
T528	LIASVIMTEDIKLNK
S561	GEEDADGSKTQDLFR
K576	RVRSILNKLTPQMFQ
K587	QMFQQLMKQVTQLAI
T596	VTQLAIDTEGASKGS
K601	IDTEGASKGSLTSSL
K637	AESATTEKPTVTVNF
K668	DDDEVFEKKQKEMDE
K686	AEERERLKEELEEAR
S700	RDIARRCSLGNIKFI
K705	RCSLGNIKFIGELFK
-	gap
K748	RLLTTIGKDLDFEKA
K754	GKDLDFEKAKPRMDQ
K768	QYFNQMEKIIKEKKT
K771	NQMEKIIKEKKTSSR
S832	QQLMAKGSDKRRGGP
R836	AKGSDKRRGGPPGPP
R846	PPGPPISRGLPLVDD
T858	VDDGGWNTVPISKGS
K863	WNTVPISKGSRPIDT
T870	KGSRPIDTSRLTKIT
T877	TSRLTKITKPGSIDS
K878	SRLTKITKPGSIDSN
S881	TKITKPGSIDSNNQL
S884	TKPGSIDSNNQLFAP
S896	FAPGGRLSWGKGSSG
K899	GGRLSWGKGSSGSGA
S902	LSWGKGSSGSGAKPS
S904	WGKGSSGSGAKPSDA
S909	SGSGAKPSDAASEVS
S913	AKPSDAASEVSRPAT
T922	VSRPATSTLNRFSAL
S947	NRRVVQRSSLSRERG
S948	RRVVQRSSLSRERGG
S950	VVQRSSLSRERGGKA
T982	DRLDRARTPATKRSF
T985	DRARTPATKRSFSKE
S988	RTPATKRSFSKEVEE
S990	PATKRSFSKEVEERS
K991	ATKRSFSKEVEERSR
S997	SKEVEERSRERPSQP
S1012	EGLRKAASLTEDRDR
T1014	LRKAASLTEDRDRGR
A1029	DAAKREAALPPVSCA
S1034	EAALPPVSCAKAALS
S1041	SCAKAALSEEELEKK
Y1056	SKAIIEEYLHLNDMK
K1207	VRLGSAGKNFCLEGQ
Y1227	ITEQKVEYTLGEESE
T1228	TEQKVEYTLGEESEA
S1233	EYTLGEESEAPGQRA
T1280	EQQIASNTLVRALMT
Y1352	RMFFDALYDEDVVKE
K1382	QGKGVALKSVTAFFK
S1399	REVEEEESDHN____

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