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Protein Page:
CENPA (human)

Overview
CENPA a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleoplasm; inner kinetochore of condensed chromosome; nucleosome; nucleus; cytosol; condensed nuclear chromosome, pericentric region; chromosome, pericentric region
Molecular Function: protein binding; DNA binding; protein heterodimerization activity; chromatin binding
Biological Process: nucleosome assembly; kinetochore assembly; DNA replication-independent nucleosome assembly at centromere; establishment of mitotic spindle orientation; viral reproduction; mitotic cell cycle
Reference #:  P49450 (UniProtKB)
Alt. Names/Synonyms: CENP-A; CENPA; Centromere autoantigen A; Centromere protein A; centromere protein A, 17kDa; Histone H3-like centromeric protein A
Gene Symbols: CENPA
Molecular weight: 15,991 Da
Basal Isoelectric point: 11.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CENPA

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S7‑p
chromatin organization, altered: S7‑p
intracellular localization: S7‑p
molecular association, regulation: S7‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
13 0 S7-p _MGPRRRsRKPEAPR
1 15 S17-p PEAPRRRsPsPtPtP
0 1 - gap
1 14 S19-p APRRRsPsPtPtPGP
0 3 P20 PRRRsPsPtPtPGPs
0 10 T21-p RRRsPsPtPtPGPsR
0 1 T23-p RsPsPtPtPGPsRRG
0 5 S27-p PtPtPGPsRRGPSLG
2187 : Phospho-CENP-A (Ser7) Antibody
  mouse

 
- gap
- gap
- gap
- gap
S15-p QTPRRRPssPAPGPS
S16-p TPRRRPssPAPGPSR
A18 RRRPssPAPGPSRQS
S22 ssPAPGPSRQSSSVG
  rat

 
- gap
- gap
S15-p GTPRRRPssPAPGPS
S16-p TPRRRPssPAPGPSQ
S40-p RTPTRRPssPAPGPS
S41-p TPTRRPssPAPGPSR
A43 TRRPssPAPGPSRRS
S47 ssPAPGPSRRSSGVG
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