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CENPA (human)

Overview CENPA a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: nucleoplasm; inner kinetochore of condensed chromosome; nucleosome; nucleus; cytosol; chromosome, pericentric region; condensed nuclear chromosome, pericentric region Molecular Function: protein binding; DNA binding; protein heterodimerization activity; chromatin binding Biological Process: nucleosome assembly; M phase of mitotic cell cycle; kinetochore assembly; DNA replication-independent nucleosome assembly at centromere; establishment of mitotic spindle orientation; virus-host interaction; mitotic cell cycle; mitotic prometaphase Reference #:  P49450 (UniProtKB) Alt. Names/Synonyms: CENP-A; CENPA; Centromere autoantigen A; Centromere protein A; centromere protein A, 17kDa; Histone H3-like centromeric protein A Gene Symbols: CENPA Molecular weight: 15,991 Da Basal Isoelectric point: 11.71  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CENPA 3AN2 - A/E=1-140 (human) 3NQJ - A=60-140 (human) 3NQU - A=1-140 (human) 3R45 - A=1-140 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3AN2 3NQJ 3NQU 3R45  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: S7‑p chromatin organization, altered: S7‑p intracellular localization: S7‑p molecular association, regulation: S7‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
12	0		S7-p	_MGPRRRsRKPEAPR
0	13		S17-p	PEAPRRRsPsPtPTP
0	13		S19-p	APRRRsPsPtPTPGP
0	9		T21-p	RRRsPsPtPTPGPsR
0	3		S27-p	PtPTPGPsRRGPSLG
0	1		R42-m1	ASSHQHSrRRQGWLK

	mouse
-	gap
-	gap
S15-p	QTPRRRPssPAPGPS
S16-p	TPRRRPssPAPGPSR
S22	ssPAPGPSRQSSSVG
R36	GSQTLRRRQKFMWLK

	rat
-	gap
-	gap
S16	TPRRRPSSPAPGPSQ
S41	TPTRRPSSPAPGPSR
S47	SSPAPGPSRRSSGVG
R61	GPQALHRRRRFLWLK

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