a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleoplasm; inner kinetochore of condensed chromosome; nucleosome; nucleus; cytosol; chromosome, pericentric region; condensed nuclear chromosome, pericentric region
Molecular Function: protein binding; DNA binding; protein heterodimerization activity; chromatin binding
Biological Process: nucleosome assembly; M phase of mitotic cell cycle; kinetochore assembly; DNA replication-independent nucleosome assembly at centromere; establishment of mitotic spindle orientation; virus-host interaction; mitotic cell cycle; mitotic prometaphase
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.