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Protein Page:
CENPA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CENPA a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleoplasm; inner kinetochore of condensed chromosome; nucleosome; nucleus; cytosol; condensed nuclear chromosome, pericentric region; chromosome, pericentric region
Molecular Function: protein binding; DNA binding; protein heterodimerization activity; chromatin binding
Biological Process: nucleosome assembly; kinetochore assembly; DNA replication-independent nucleosome assembly at centromere; establishment of mitotic spindle orientation; viral reproduction; mitotic cell cycle
Reference #:  P49450 (UniProtKB)
Alt. Names/Synonyms: CENP-A; CENPA; Centromere autoantigen A; Centromere protein A; centromere protein A, 17kDa; Histone H3-like centromeric protein A
Gene Symbols: CENPA
Molecular weight: 15,991 Da
Basal Isoelectric point: 11.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CENPA

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S7‑p
chromatin organization, altered: S7‑p
intracellular localization: S7‑p
molecular association, regulation: S7‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
12 0 S7-p _MGPRRRsRKPEAPR
1 17 S17-p PEAPRRRsPsPtPtP
0 1 - gap
1 16 S19-p APRRRsPsPtPtPGP
0 3 P20 PRRRsPsPtPtPGPs
0 10 T21-p RRRsPsPtPtPGPsR
0 1 T23-p RsPsPtPtPGPsRRG
0 5 S27-p PtPtPGPsRRGPSLG
0 1 R42-m1 ASSHQHSrRRQGWLK
2187 : Phospho-CENP-A (Ser7) Antibody
  mouse

 
- gap
- gap
- gap
- gap
S15-p QTPRRRPssPAPGPS
S16-p TPRRRPssPAPGPSR
A18 RRRPssPAPGPSRQS
S22 ssPAPGPSRQSSSVG
R36 GSQTLRRRQKFMWLK
  rat

 
- gap
- gap
S15-p GTPRRRPssPAPGPS
S16-p TPRRRPssPAPGPSQ
S40-p RTPTRRPssPAPGPS
S41-p TPTRRPssPAPGPSR
A43 TRRPssPAPGPSRRS
S47 ssPAPGPSRRSSGVG
R61 GPQALHRRRRFLWLK
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