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Protein Page:
TIRAP (mouse)

Overview
TIRAP an adapter protein involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, ERK1, ERK2 and JNK, resulting in cytokine secretion and the inflammatory response. Homodimerizes. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9. Genetic variations in TIRAP can influence susceptibility or resistance to infectious diseases, including invasive pneumococcal disease, malaria and tuberculosis. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: membrane; endocytic vesicle; cytoplasm; plasma membrane; peroxisome; intracellular
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity; protein kinase C binding; protein heterodimerization activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of toll-like receptor 3 signaling pathway; immune system process; positive regulation of interleukin-12 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of JNK cascade; response to lipopolysaccharide; regulation of interleukin-15 production; signal transduction; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor 2 signaling pathway; activation of JNK activity; regulation of innate immune response; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; positive regulation of interleukin-8 production; defense response to Gram-positive bacterium; cell surface receptor linked signal transduction; response to bacterium; positive regulation of interleukin-15 production; positive regulation of innate immune response; positive regulation of B cell proliferation; innate immune response; myeloid cell differentiation; regulation of interferon-beta production; inflammatory response
Reference #:  Q99JY1 (UniProtKB)
Alt. Names/Synonyms: AA407980; Adaptor protein Wyatt; C130027E04Rik; Mal; MyD88 adapter-like protein; MyD88-adapter-like; TIR domain-containing adapter protein; Tirap; Tlr4ap; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; Toll-like receptor 4 adaptor protein; Toll/interleukin-1 receptor domain-containing adapter protein; wyatt
Gene Symbols: Tirap
Molecular weight: 26,035 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TIRAP

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S3 _____MASSSSVPAS
0 1 S74-p HSSPESRsSPSSCSS
0 1 T86-p CSSGMSPtSPPtHVD
0 1 T90-p MSPtSPPtHVDSSSS
0 1 S99-p VDSSSSSsGRWSKDY
3 0 Y106 sGRWSKDYDVCVCHS
3 1 Y126 AAQELVSYLEGSQAS
0 1 A144 FLQLRDAAPGGAIVS
2 0 Y207 SGLSRAAYPPELRFM
0 1 Y236 VKEAVIHYLETLS__
0 1 T239 AVIHYLETLS_____
0 1 S241 IHYLETLS_______
  human

 
S3-p _____MAsSTSLPAP
P56 QPTSQDSPLPPSLSS
S68 LSSVTSPSLPPTHAS
T72 TSPSLPPTHASDSGS
S79 THASDSGSSRWSKDy
Y86-p SSRWSKDyDVCVCHS
Y106-p AAQDLVSyLEGSTAS
T124-p FLQLRDAtPGGAIVS
Y187-p SGLSRAAyPPELRFM
Y216-p VKEAVMRyLQtLs__
T219-p AVMRyLQtLs_____
S221-p MRyLQtLs_______
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